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  4. Recombinant Mouse Semaphorin-7A (Sema7a)

Recombinant Mouse Semaphorin-7A (Sema7a)

  • 中文名称：
    小鼠Sema7a重组蛋白
  • 货号：
    CSB-YP889544MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sema7a重组蛋白
  • 货号：
    CSB-EP889544MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sema7a重组蛋白
  • 货号：
    CSB-EP889544MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sema7a重组蛋白
  • 货号：
    CSB-BP889544MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sema7a重组蛋白
  • 货号：
    CSB-MP889544MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sema7a
  • Uniprot No.：
  • 别名：
    Sema7a; Cd108; Semal; Semk1; Semaphorin-7A; Semaphorin-K1; Sema K1; Semaphorin-L; Sema L; CD antigen CD108
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    45-646
  • 氨基酸序列
    QGHSRS GPRISAVWKG QDHVDFSQPE PHTVLFHEPG SFSVWVGGRG KVYHFNFPEG KNASVRTVNI GSTKGSCQDK QDCGNYITLL ERRGNGLLVC GTNARKPSCW NLVNDSVVMS LGEMKGYAPF SPDENSLVLF EGDEVYSTIR KQEYNGKIPR FRRIRGESEL YTSDTVMQNP QFIKATIVHQ DQAYDDKIYY FFREDNPDKN PEAPLNVSRV AQLCRGDQGG ESSLSVSKWN TFLKAMLVCS DAATNRNFNR LQDVFLLPDP SGQWRDTRVY GVFSNPWNYS AVCVYSLGDI DRVFRTSSLK GYHMGLPNPR PGMCLPKKQP IPTETFQVAD SHPEVAQRVE PMGPLKTPLF HSKYHYQKVV VHRMQASNGE TFHVLYLTTD RGTIHKVVES GDQDHSFVFN IMEIQPFHRA AAIQAISLDA DRRKLYVTSQ WEVSQVPLDM CEVYSGGCHG CLMSRDPYCG WDQDRCVSIY SSQRSVLQSI NPAEPHRECP NPKPDEAPLQ KVSLARNSRY YLTCPMESRH ATYLWRHEEN VEQSCEPGHQ SPSCILFIEN LTARQYGHYR CEAQEGSYLR EAQHWELLPE DRALAEQLMG HARALA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
  • 基因功能参考文献：
    1. Sema7A-PlxnC1 interaction is essential to form the post-synaptic assembly. PMID: 29743476
    2. During differentiation of adult-born dentate gyrus granule cells, Sema7A promotes dendrite growth, complexity and spine development through beta1-subunit-containing integrin receptors. PMID: 28281529
    3. Genetic ablation of host-derived SEMA7A further enhanced the antitumor effects of SEMA7A shRNA gene silencing in 4T1 cells. Our preclinical findings demonstrate a critical role for SEMA7A in mediating mammary tumor progression. PMID: 29048670
    4. sema7A is involved in peripheral immunity and central nervous system inflammation in multiple sclerosis pathogenesis. PMID: 27714632
    5. These findings indicate that Sema7A as a potent activator of T cells and monocytes in the immune response contributes to the inflammation and progression of rheumatoid arthritis PMID: 28109308
    6. Our results suggest that semaphorin 7a may be novel target for blocking breast tumor progression. PMID: 27065336
    7. SEMA7A plays a critical role in IgE-mediated neutrophilic airway inflammation PMID: 26144372
    8. SEMA7A has a role in the development of lung injury PMID: 26752048
    9. Data suggest that sema7A is involved in the pathogenesis of experimental autoimmune encephalomyelitis, in the modulation of the immune response and in the neurodegeneration that take place in the CNS. PMID: 26686462
    10. This study demonstrates that Sema7A controls the assembly of actin-based protrusions that drive Dendritic cell migration in response to CCL21. PMID: 26597008
    11. Sem7a and its receptors regulate Chi3l1 in pulmonary melanoma metastasis PMID: 25511377
    12. These data identify Sema7A as a regulator of thalamocortical and local circuit development in layer 4 and provide a molecular handle that can be used to explore the coordinated generation of excitatory and inhibitory cortical circuits. PMID: 25201975
    13. SEMA7A was expressed in the liver and was increased in the course of liver fibrosis, both in mice and in humans. PMID: 23850082
    14. Oncogenic Ras may play a role in epithelial mesenchymal transition via the ERF and regulation of Semaphorin-7a. PMID: 22875994
    15. We report here the expression and induction of semaphorin 7A (SEMA7A) on endothelium through hypoxia-inducible factor 1alpha during hypoxia. PMID: 22891341
    16. Sema7A mediates signaling through smad6 during West Nile virus infection in an analysis of smad6 expression in cortical neurons from sema7A-deficient mice. PMID: 22896629
    17. Sema7a is expressed constitutively in the cornea, and potently stimulates nerve regeneration and inflammatory cell influx. PMID: 22700709
    18. Sema7A plays crucial roles in suppressing intestinal inflammation through alphavbeta1 integrin, but also provides a novel mode of IL-10 induction via interactions between IECs and Mvarphis PMID: 22198947
    19. GnRH-1 cells differentially express the Sema7 receptors beta1-integrin and Plexin C1 as a function of their migratory stage. PMID: 21903667
    20. Sema7A was expressed in vascularized corneas and showed pro-angiogenic properties in our corneal model. PMID: 21999225
    21. interventions that reduce semaphorin 7a expression or prevent the semaphorin 7a-beta1 integrin interaction may ameliorate TGFbeta1-driven or fibrocyte-associated autoimmune fibroses. PMID: 21484765
    22. Sema7A enhancement of axon outgrowth requires integrin receptors and activation of MAPK signalling pathways PMID: 12879062
    23. we have investigated its regulation and function in bone cells.Its expression is also regulated during primary osteoclast differentiation in vitro PMID: 15859945
    24. findings not only identify a function of Sema7A as an effector molecule in T-cell-mediated inflammation, but also reveal a mechanism of integrin-mediated immune regulation PMID: 17377534
    25. Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis. PMID: 17485510
    26. Semaphorin 7A is a novel substrate for caspase-9 that can be used to monitor caspase-9 activity in mice. PMID: 19741144

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
  • 蛋白家族：
    Semaphorin family
  • 组织特异性：
    Highly expressed in activated T-cells (at protein level). Highest expression in brain. Lower in heart, thymus, spleen, testis and ovary. The expression increases in late embryonic and postnatal stages. Detected in T-cells.
  • 数据库链接：

    KEGG: mmu:20361

    STRING: 10090.ENSMUSP00000042211

    UniGene: Mm.335187