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  4. Recombinant Mouse Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (Ppp2r5a)

Recombinant Mouse Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (Ppp2r5a)

  • 中文名称：
    小鼠Ppp2r5a重组蛋白
  • 货号：
    CSB-YP761330MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ppp2r5a重组蛋白
  • 货号：
    CSB-EP761330MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ppp2r5a重组蛋白
  • 货号：
    CSB-EP761330MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ppp2r5a重组蛋白
  • 货号：
    CSB-BP761330MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ppp2r5a重组蛋白
  • 货号：
    CSB-MP761330MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ppp2r5aSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; PP2A B subunit isoform B'-alpha; PP2A B subunit isoform B56-alpha; PP2A B subunit isoform PR61-alpha; PR61alpha; PP2A B subunit isoform R5-alpha
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-486
  • 氨基酸序列
    MSSPSPPAPV ACAAISASEK VDGFTRKSVR KAQRQKRSQG SSQFRSQGSQ AELHPLPQLK DATSNEQQEL FCQKLQQCCV LFDFMDSVSD LKSKEIKRAT LNELVEYVST NRGVIVESAY SDIVKMISAN IFRTLPPSDN PDFDPEEDEP TLEASWPHIQ LVYEFFLRFL ESPDFQPSIA KRYIDQKFVQ QLLELFDSED PRERDFLKTV LHRIYGKFLG LRAFIRKQIN NIFLRFIYET EHFNGVAELL EILGSIINGF ALPLKAEHKQ FLMKVLIPMH TAKGLALFHA QLAYCVVQFL EKDTTLTEPV IRGLLKFWPK TCSQKEVMFL GEIEEILDVI EPTQFKKIEE PLFKQISKCV SSSHFQVAER ALYFWNNEYI LSLIEENIDK ILPIMFASLY KISKEHWNQT IVALVYNVLK TLMEMNGKLF DDLTSSYKAE RQREKKKELE REELWKKLEE LQLKKALEKQ NNAYNMHSIR SSTSAK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
  • 基因功能参考文献：
    1. in vivo expression of B56alpha suppressed parasympathetic regulation of heart rate and increased RyR2 phosphorylation in cardiomyocytes. PMID: 26198358
    2. Cardiomyocyte-directed overexpression of B56alpha, the main cardiac PP2A regulatory subunit, results in the dephosphorylation of myofilament proteins, increased Ca2+ sensitivity, and higher contractility. PMID: 25320082
    3. reversible phosphorylation of Dzip1, which is controlled by the antagonistic action of CK2 and B56-containing PP2As, has an important impact on the stability of Gli transcription factors and Hh signaling. PMID: 21878643
    4. Elevated B56alpha/PP2A inhibits hormone-sensitive lipase and lipolysis in white adipose tissue of DIO mice. PMID: 20534721
    5. B56alpha has a role in nuclear export of the catalytic subunit of PP2A PMID: 20378546
    6. Protein phosphatase 2A contributes to the cardiac dysfunction induced by endotoxemia. PMID: 19201758

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Chromosome, centromere.
  • 蛋白家族：
    Phosphatase 2A regulatory subunit B56 family
  • 组织特异性：
    Widely expressed with highest levels in thymus and ovary.
  • 数据库链接：

    KEGG: mmu:226849

    STRING: 10090.ENSMUSP00000070726

    UniGene: Mm.205569