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  4. Recombinant Mouse Sialic acid-binding Ig-like lectin 12 (Siglec12), partial

Recombinant Mouse Sialic acid-binding Ig-like lectin 12 (Siglec12), partial

  • 中文名称：
    小鼠Siglec12重组蛋白
  • 货号：
    CSB-YP835592MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Siglec12重组蛋白
  • 货号：
    CSB-EP835592MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Siglec12重组蛋白
  • 货号：
    CSB-EP835592MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Siglec12重组蛋白
  • 货号：
    CSB-BP835592MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Siglec12重组蛋白
  • 货号：
    CSB-MP835592MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Siglec12
  • Uniprot No.：
  • 别名：
    Siglec12; Siglec5; Siglece; Siglecl1; Sialic acid-binding Ig-like lectin 12; Siglec-12; Myeloid inhibitory siglec; MIS; Sialic acid-binding Ig-like lectin 5; Siglec-5; Sialic acid-binding Ig-like lectin E; Siglec-E; mSiglec-E; Sialic acid-binding Ig-like lectin-like 1; Siglec-L1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
  • 基因功能参考文献：
    1. The Siglec-E-deficient dendritic cells were defective for TRIF-mediated IFN-beta production in response to E. coli infection. PMID: 27619995
    2. This study demonstrated that virulent parasite Leishmania donovani (AG83+Sias) establish a unique sialic acids-mediated binding and subsequent phagocytosis in the host cell through the selective exploitation of siglec-1. PMID: 27494323
    3. new data relating to the structure and function of Siglec-E, the major CD33-related Siglec expressed on mouse neutrophils, monocytes, macrophages, and dendritic cells. PMID: 27920204
    4. indicate that Siglec-9 affects several different signaling pathways in IL-4-stimulated macrophages, which resulted in enhanced induction of Arg1 in Siglec-9-expressing RAW264 cells PMID: 26540411
    5. Competitive ELISA assays confirmed the involvement of sulfated epitopes in the affinity between Siglec-E and cruzipain, probably modified by natural protein environment PMID: 26047932
    6. Data indicate a role for neuraminidase 1 (Neu1) in regulating Siglec E protein-toll-like receptor 4 (TLR4) interaction and endotoxemia. PMID: 25187624
    7. Siglec-E-deficient macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary role of CD33-related Siglecs in limiting cancer-promoting inflammation and tumor growth. PMID: 25225409
    8. Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo. PMID: 24391502
    9. siglec-E functions as an inhibitory receptor of neutrophils via positive regulation of NADPH oxidase activation and ROS production PMID: 24895121
    10. These results suggest that sSiglec-9 has an antitumor benefit against MUC1-expressing tumor in the transgenic mice. PMID: 24924635
    11. Siglec-9 expressed on immune cells may play a role as a potential counterreceptor for MUC1 and that this signaling may be another MUC1-mediated pathway and function in parallel with a growth factor-dependent pathway. PMID: 24045940
    12. Siglec-E is an important negative regulator of neutrophil recruitment to the lung and beta2 integrin-dependent signaling. PMID: 23315163
    13. Early murine T-lymphocyte activation is accompanied by a switch from N-Glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E PMID: 21835922
    14. Siglec-E is induced in a MyD88-dependent manner. Once up-regulated, it can control TLR-dependent NF-kappaB antiviral responses by directly inhibiting TLR-induced antiviral cytokine production. PMID: 19933851
    15. Siglec-E interacted with the pathogenic Tulahuen strain, but showed a diminished binding to the Tehuantepec strain of Trypanosoma cruzi PMID: 19552697
    16. are a family of sialic acid receptor proteins expressed in immune cells, recognize their ligands and play a role in the signal transduction. PMID: 18453149

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
  • 组织特异性：
    Expressed by monocytic/myeloid lineage cells. Found at higher levels in spleen, liver and heart. Found at lower levels in kidney and lung.
  • 数据库链接：

    KEGG: mmu:83382

    STRING: 10090.ENSMUSP00000032667

    UniGene: Mm.157702