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  4. Recombinant Mouse Sigma non-opioid intracellular receptor 1 (Sigmar1), partial

Recombinant Mouse Sigma non-opioid intracellular receptor 1 (Sigmar1), partial

  • 中文名称：
    小鼠Sigmar1重组蛋白
  • 货号：
    CSB-YP021320MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sigmar1重组蛋白
  • 货号：
    CSB-EP021320MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sigmar1重组蛋白
  • 货号：
    CSB-EP021320MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sigmar1重组蛋白
  • 货号：
    CSB-BP021320MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sigmar1重组蛋白
  • 货号：
    CSB-MP021320MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Sigmar1; Oprs1; Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; Sigma1-receptor; Sigma1R
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112.
  • 基因功能参考文献：
    1. The current study demonstrates that rapidly dephosphorylated spinal astrocyte aromatase is associated with the development of formalin-induced acute nociception. Moreover, activation of astrocyte sigma-1 receptors leads to a calcineurin-mediated dephosphorylation of aromatase resulting in the rapid modulation of this enzyme. PMID: 29289721
    2. Disruption of the association of Sig-1R with TRPV1 by synthetic or natural antagonists leads to degradation of TRPV1 protein and to decreased levels of the ion channel protein as well as to a decrease in TRPV1-associated pain. PMID: 29378958
    3. Oprs1 neuroprotective effect has been demonstrated in a cell model of Huntington's disease. PMID: 29177899
    4. This study reveals previously uncharacterized S1R-associated mechanisms during rd10 photoreceptor degeneration PMID: 28927431
    5. l-THP possesses antinociceptive effects through spinal Sig-1R mechanism and may be a useful analgesic in the management of neuropathic pain PMID: 27910870
    6. Results indicate that the sigma1R deficiency in basolateral amygdala principal neurons via NMDA recetpor dysfunction suppresses nNOS activity and NO production to reduce GABA-A receptor-mediated inhibition, which impairs long-term depression induction and causes depressive-like phenotype. PMID: 28108357
    7. Sigma 1 receptor (Sig1R) activation modifies intracellular calcium exchange in the G93A(hSOD1) amyotrophic lateral sclerosis model. Study shows, intracellular Ca(2+) shuttling can be manipulated by Sig1R activation. PMID: 28723387
    8. Chronic pharmacological stimulation of sigma1rs induces learning and memory behavioral improvement in an ischemia model. Significant neurorestorative effects may be favored by a BDNF neurotrophic effect. The involvement of an antagonist of NR2A revealed that the improvement of learning and memory impairment, mediated by BDNF through sigma1r activation, relied on the NR2A-induced CaMKIV-TORC1-p-CREB pathway. PMID: 28431607
    9. Expression of sigma-1 receptor is specifically increased in ischemic penumbral neurons within hours after middle cerebral artery occlusion. PMID: 28687423
    10. Its deficiency through enhanced aggregation and phosphorylation of alphaSyn causes the loss of dopaminergic neurons leading to the decline of motor coordination. PMID: 28870519
    11. Sig1R activation preserves retinal thickness and diminishes retinal detachment in Pde6beta mutant mice. PMID: 27298364
    12. Methamphetamine induced microglial apoptosis via its cognate receptor sigma-1R. Furthermore, this effect was mediated by activation of MAPKs and PI3K/Akt pathways and subsequent translocation of p53 into nucleus, resulting in activation of caspase, ultimately leading to cell apoptosis. sigma-1R plays a critical role in eliciting innate immune responses in microglia. PMID: 27189473
    13. Findings identified five alternatively spliced variants of the sigma1 receptor gene Sigmar1 using a polymerase chain reaction cloning approach. PMID: 28350844
    14. Activation of S1R, necessary for its effect on the BDNF pathway, represents a core component of the mode of action of pridopidine. Since the newly identified pathways are downregulated in neurodegenerative diseases, including Huntington Disease (HD) , these findings suggest that pridopidine may exert neuroprotective effects beyond its role in alleviating some symptoms of HD. PMID: 27466197
    15. Findings demonstrate that spinal cord injury activates astrocyte sigma-1 receptors leading to increases in the expression of the gap junction protein, connexin 43 and astrocyte activation in the lumbar dorsal horn, and ultimately contribute to the induction of bilateral below-level mechanical allodynia. PMID: 27567941
    16. Study found: sigma-1 receptor is abundant in dorsal root ganglion (DRG) neuronal soma, but not in satellite cells; sigma-1 receptor is absent in processes of DRG neurons; in DRG neurons, S1R targets endoplasmic reticulum, nuclear envelope, and plasma membrane. PMID: 27339730
    17. Utilizing the sigma-1R knockout mouse and electrophysiological recordings, we found no change in neuronal excitability and glutamatergic synaptic function PMID: 27260635
    18. Sigma1R may be a novel retinal stress modulator, and targeting it even after disease onset may afford retinal neuroprotection. PMID: 27206247
    19. Study focused on sigma-1 receptor (Sig-1R), a chaperone at endoplasmic reticulum, and investigated its protective functions; results reveal that zinc finger protein 179 plays a novel role in neuroprotection. PMID: 26792191
    20. Sigma-1 receptors play a major role in inflammatory response after traumatic brain injury PMID: 26228028
    21. Results suggest that Sig-1Rs modulate ethanol drinking, locomotor stimulation and conditioned taste aversion, strengthening the notion that drugs acting on the Sig-1R system may have potential for treating alcohol-use disorders PMID: 26462569
    22. Sig-1R was moderately expressed in pyramidal neurons in hippocampal regions CA3 and CA1 and faintly in DG granule cells. Fluvoxamine or SA4503 treatment but not paroxetine restores decrease in Sig-1R and ATP production in the DG of CaMKIV null mice. PMID: 25316382
    23. The neuroprotective role of sigma1R may be linked directly to the oxidative stress-mediating properties of supportive glial cells. PMID: 25920363
    24. Results indicate that the sigma1R deficiency impairs neurogenesis leading to a depressive-like phenotype, which is alleviated by the neuroprotection of estradiol PMID: 25983018
    25. The sigma-1R deficiency through suppressing NR2B function and DAT expression can reduce MPTP-induced death of dopaminergic neurons and parkinsonism. PMID: 26203861
    26. These results demonstrate a role of Sig-1R in transcriptional regulation. PMID: 26554014
    27. This study demonstrated that methamphetamine-mediated activation of astrocytes involved up-regulation of sigma-1 receptor. PMID: 25889537
    28. The sigma1R antagonists enhance opioid analgesia in naive mice by releasing mu-opioid receptors from the negative influence of NMDARs, and they also reset antinociception in morphine tolerant animals. PMID: 25557043
    29. Allosteric modulation of sigma-1 receptors by SKF83959 inhibits mouse BV2-microglia-mediated inflammation. PMID: 26031312
    30. Sigma-1 receptors play a major role in inflammatory hyperalgesia. PMID: 24639046
    31. In a neuropathic pain model, OPRS1 activates astrocytes via p38 MAPK phosphorylation, leading to development of mechanical allodynia. PMID: 25158784
    32. These results indicate that the sigma1R deficiency can reduce Abeta(25-35)-induced neuronal cell death and cognitive deficits through suppressing Abeta(25-35)-enhanced NR2B phosphorylation. PMID: 25286118
    33. Sigma1R controls the extent of CB1-NMDAR interaction and its failure might constitute a vulnerability factor for cannabis abuse, potentially precipitating schizophrenia that might otherwise be induced later in time by the endogenous system. PMID: 24485144
    34. Disruption of SIGMAR1 function in motor neurons disturbed endoplasmic reticulum-mitochondria contacts. PMID: 25678561
    35. results support the notion that loss of SigR1 function contributes to ALS pathology by causing abnormal ER morphology, lipid raft destabilization and defective endolysosomal pathways. PMID: 24922074
    36. sigmaR1 regulates endoplasmic reticulum stress in retinal Muller cells and that the role of sigmaR1 in retinal neuroprotection probably involves BCL2. PMID: 24469320
    37. These results suggest that activation of the sigma1R is necessary for development of the sensory nerve mitochondrial damage and neuropathic pain produced by paclitaxel. PMID: 24517272
    38. The results of this study suggest that sigma-1 receptor regulates endogenous defence and plasticity mechanisms in experimental parkinsonism. PMID: 24755275
    39. It has biphasic functions as orphan receptor and molecular chaperon. PMID: 24813800
    40. Prolongation of immobility in forced swimming test is modulated through sigma 1 receptor and acetylcholine receptor. PMID: 24162025
    41. Sigma-1 receptor knockout impairs neurogenesis in dentate gyrus of adult hippocampus via down-regulation of NMDA receptors. PMID: 23745740
    42. Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats. PMID: 23732704
    43. sigma-1 receptor cts as a brake on excitability, an effect that might enhance longevity in an amyotrophic lateral sclerosis mouse model. PMID: 23458708
    44. stimulation of the sigma-1 receptor by DHEA enhances synaptic efficacy and neurogenesis PMID: 23593332
    45. Our results support the notion that SigR1 is abnormally modified and contributes to the pathogenesis of amyotrophic lateral sclerosis . PMID: 23314020
    46. Findings suggest that NE-100 suppresses ER stress-induced cell death via CHOP expression by the upregulation of GRP78 through ATF6 pathway, independent sigma-1 receptor antagonist effect. PMID: 23618865
    47. sigma1R stimulation with the specific agonist SA4503 ameliorates cardiac hypertrophy and dysfunction by restoring both mitochondrial Ca(2+) mobilization and ATP production via sigma1R stimulation PMID: 23298811
    48. Sigma receptor 1 plays a key role in modulating retinal stress and may be an important target for retinal disease. PMID: 23233788
    49. Sigma 1 receptors play a role in the mechanisms underlying induced visceral pain. PMID: 23299362
    50. Data indicate that sigma1-receptor short form sigma(1)SR isoform interferes with sigma(1)R function relevant to mitochondrial energy production under endoplasmic reticulum stress conditions, promoting cellular apoptosis. PMID: 22619170

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  • 亚细胞定位：
    Nucleus inner membrane. Nucleus outer membrane. Nucleus envelope. Cytoplasmic vesicle. Endoplasmic reticulum membrane. Membrane; Single-pass membrane protein. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone. Cell junction, synapse, postsynaptic density membrane.
  • 蛋白家族：
    ERG2 family
  • 组织特异性：
    Widely expressed with higher expression in liver, brain, kidney and thymus. Expressed throughout the brain with higher expression within cerebral cortex, hippocampus and cerebellum. Within the hippocampus expressed in cornu ammonis pyramidal neurons, the
  • 数据库链接：

    KEGG: mmu:18391

    STRING: 10090.ENSMUSP00000056027

    UniGene: Mm.425181