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  4. Recombinant Mouse Sodium-dependent neutral amino acid transporter B (0)AT2 (Slc6a15), partial

Recombinant Mouse Sodium-dependent neutral amino acid transporter B (0)AT2 (Slc6a15), partial

  • 中文名称：
    小鼠Slc6a15重组蛋白
  • 货号：
    CSB-YP806346MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc6a15重组蛋白
  • 货号：
    CSB-EP806346MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc6a15重组蛋白
  • 货号：
    CSB-EP806346MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc6a15重组蛋白
  • 货号：
    CSB-BP806346MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc6a15重组蛋白
  • 货号：
    CSB-MP806346MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc6a15
  • Uniprot No.：
  • 别名：
    Slc6a15; B0at2; Ntt73; Sodium-dependent neutral amino acid transporter B(0)AT2; Sodium- and chloride-dependent neurotransmitter transporter NTT73; Solute carrier family 6 member 15; Transporter v7-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for methionine and for the branched-chain amino acids, particularly leucine, valine and isoleucine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.
  • 基因功能参考文献：
    1. Our study demonstrates a role for reduced Slc6a15, a neutral amino acid transporter, in nucleus accumbens (NAc) in depression and stress susceptibility. The reduction of Slc6a15 occurs selectively in the NAc D2-neurons. Genetic reduction of Slc6a15 induces susceptibility to a subthreshold stress, while genetic overexpression in D2-neurons prevents social avoidance after chronic social defeat stress. PMID: 28576941
    2. Slc6a15 plays a role in modulating emotional behavior, possibly mediated by its impact on glutamatergic neurotransmission. PMID: 26585320
    3. SLC6A15 regulates the activity of the brain glutamatergic system through the proline-glutamate biosynthesis pathway, affecting hippocampal neurochemistry and consequently behavior. PMID: 26228428
    4. The structure and function of B0AT2 are reported. PMID: 16185194
    5. Slc6a15 knockout mice demonstrate only modest alterations in rotarod performance with aging and lack reproducible alterations in other motor, memory, anxiety or olfactory tests PMID: 17931606

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A15 subfamily
  • 组织特异性：
    Significant expressed in brain, lung and kidney. regions, the cortex, the cerebellum and the brain stem.
  • 数据库链接：

    KEGG: mmu:103098

    STRING: 10090.ENSMUSP00000073829

    UniGene: Mm.458408