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  4. Recombinant Mouse Solute carrier family 17 member 9 (Slc17a9), partial

Recombinant Mouse Solute carrier family 17 member 9 (Slc17a9), partial

  • 中文名称：
    小鼠Slc17a9重组蛋白
  • 货号：
    CSB-YP855324MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc17a9重组蛋白
  • 货号：
    CSB-EP855324MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc17a9重组蛋白
  • 货号：
    CSB-EP855324MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc17a9重组蛋白
  • 货号：
    CSB-BP855324MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc17a9重组蛋白
  • 货号：
    CSB-MP855324MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc17a9
  • Uniprot No.：
  • 别名：
    Slc17a9; Solute carrier family 17 member 9
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles.
  • 基因功能参考文献：
    1. FLX-induced anti-depressive behavior was decreased in astrocyte-selective VNUT-knockout mice or when VNUT was deleted in mice, but it was increased when astrocyte-selective VNUT was overexpressed in mice PMID: 29887330
    2. VNUT is necessary for exocytotic ATP release from spinal dorsal horn neurons which contributes to neuropathic pain. PMID: 27515581
    3. This study provides a molecular mechanism for lysosomal ATP transport mediated by SLC17A9 and also suggests a regulatory mechanism of lysosomal P2X4 by SLC17A9 PMID: 27477609
    4. clock genes exist in the mouse bladder mucosa and regulate exact circadian gene expression in mice PMID: 28060940
    5. Functional VNUT is expressed in the rodent retina, and these results suggest that ATP is released from photoreceptor cells, bipolar cells, amacrine cells, and astrocytes as well as Muller cells to initiate purinergic chemical transmission PMID: 27040629
    6. VNUT expression was significantly increased during glaucoma progression in a mouse model. PMID: 26392744
    7. In vitro expression of VNUT decreases neuritogenesis in N2a cells differentiated by retinoic acid treatment PMID: 25847073
    8. These results demonstrated an essential role of VNUT in vesicular storage and release of ATP in neuroendocrine cells in vivo and suggest that vesicular ATP and/or its degradation products act as feedback regulators in catecholamine and insulin secretion. PMID: 25331291
    9. The VNUT-dependent ATP release pathway is associated with an induced secretion process and downstream purinergic signalling. PMID: 24488439
    10. These results demonstrate that intestinal L cells express VNUT (vesicular nucleotide transporter )and suggest that L cells are purinergic in nature and secrete nucleotides. PMID: 24989000
    11. VNUT mediates transport of ATP into synaptic vesicles of hippocampal neurons. PMID: 21810784
    12. the existence of an SLC17A9-dependent ATP-enriched vesicular pool in biliary epithelium that undergoes regulated exocytosis to initiate purinergic signaling. PMID: 21613220
    13. analysis of involvement of SLC17A9-dependent vesicular exocytosis in the mechanism of ATP release during T cell activation PMID: 20382737
    14. SLC17A9 protein acts as a vesicular nucleotide transporter (VNUT) and plays an essential role in vesicular storage of ATP in the ATP-secreting cells PMID: 18375752

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Sodium/anion cotransporter family
  • 组织特异性：
    In brain, specifically expressed in the medulla and is associated with chromaffin granules (at protein level). Predominantly expressed in adrenal gland, brain and thyroid.
  • 数据库链接：

    KEGG: mmu:228993

    STRING: 10090.ENSMUSP00000091771

    UniGene: Mm.87189