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  4. Recombinant Mouse Solute carrier family 22 member 1 (Slc22a1), partial

Recombinant Mouse Solute carrier family 22 member 1 (Slc22a1), partial

  • 中文名称：
    小鼠Slc22a1重组蛋白
  • 货号：
    CSB-YP021442MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc22a1重组蛋白
  • 货号：
    CSB-EP021442MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc22a1重组蛋白
  • 货号：
    CSB-EP021442MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc22a1重组蛋白
  • 货号：
    CSB-BP021442MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc22a1重组蛋白
  • 货号：
    CSB-MP021442MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc22a1
  • Uniprot No.：
  • 别名：
    Slc22a1; Lx1; Oct1; Solute carrier family 22 member 1; Organic cation transporter 1; mOCT1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.
  • 基因功能参考文献：
    1. we unraveled substrate affinities and modulation of transport activity by acute regulation by protein kinases on mOCT1 and mOCT2 PMID: 24233562
    2. Data indicate that the expression of the organic cation transporters Slc22a1, Slc22a2 and Slc22a3 essential for the cellular uptake of metformin was highly suppressed in Tsc1+/-renal tumours. PMID: 23228442
    3. Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen. PMID: 22300281
    4. The influence of organic cation transporters 1, 2, and 3 (OCT1, OCT2, and OCT3) and their genetic variants on cellular uptake of picoplatin and on the individual components of the ensuing cytotoxicity such as DNA adduct formation, was determined. PMID: 20371711
    5. Oct1 forms repeating, cyclosporin-sensitive regulatory modules within the CD21 intronic control region. PMID: 11907091
    6. rOCT1 could transport the nucleoside analog deoxytubercidin PMID: 12123738
    7. Involvement in hepatic and intestinal distribution of metformin. PMID: 12130709
    8. a comparison of the transport properties of Oct2 and Oct1 PMID: 12176030
    9. oct1 has a role in controlling fgl2 expression in endothelial cells PMID: 12752447
    10. This study shows that Oct1 and Oct2 together are essential for renal secretion of (small) organic cations. PMID: 14560032
    11. nuclear factor Y and Oct-1 bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated expression of the mGnRH receptor gene PMID: 15388790
    12. The purpose of this study was to examine the effects of peroxisome proliferator agonist receptor agonists on the hepatic regulation and function of Slc22a1. PMID: 15458920
    13. a multiprotein complex containing GATA-1, Oct-1, and other protein factors may contribute to the formation of a repressive chromatin structure that silences gamma-globin gene expression PMID: 15613485
    14. Oct-1 has an important role in IFN-A regulation PMID: 16166650
    15. Doubling of airway epithelial acetylcholine (ACh) in OCT1/2-/- mice is consistent with OCT1 and/or 2 mediating ACh release from respiratory epithelium. This effect does not contribute to 5-HT-induced constriction of murine intrapulmonary bronchi. PMID: 16608531
    16. The ubiquitous Oct-1 transcription factor may be involved in hormonally regulated, tissue-specific beta-casein gene expression. PMID: 16965262
    17. Real-time RT-PCR revealed significant decreases in OCT1 mRNA in the lung of sensitized and allergen challenged animals. PMID: 17328924
    18. Genetic variation in OCT1 may contribute to variation in individual response to the drug. PMID: 17476361
    19. Effect of OCT1 genotype on metformin pharmacokinetics in mice was less than in humans. PMID: 17609683
    20. the interaction of glucocorticoid receptor with Oct-1 on the beta-casein gene promoter PMID: 19266165

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  • 亚细胞定位：
    Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
  • 组织特异性：
    Highly expressed in liver, kidney and intestine. Weakly expressed in adrenals and in lacting mammary glands.
  • 数据库链接：

    KEGG: mmu:20517

    STRING: 10090.ENSMUSP00000024596

    UniGene: Mm.594