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  4. Recombinant Mouse Solute carrier organic anion transporter family member 1B2 (Slco1b2), partial

Recombinant Mouse Solute carrier organic anion transporter family member 1B2 (Slco1b2), partial

  • 中文名称：
    小鼠Slco1b2重组蛋白
  • 货号：
    CSB-YP878075MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slco1b2重组蛋白
  • 货号：
    CSB-EP878075MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slco1b2重组蛋白
  • 货号：
    CSB-EP878075MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slco1b2重组蛋白
  • 货号：
    CSB-BP878075MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slco1b2重组蛋白
  • 货号：
    CSB-MP878075MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slco1b2
  • Uniprot No.：
  • 别名：
    Slco1b2; Oatp1b2; Slc21a10; Solute carrier organic anion transporter family member 1B2; Liver-specific organic anion transporter 1; LST-1; SLC21A6; Solute carrier family 21 member 10
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates the Na(+)-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates such as estrone-3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate and prostaglandin E2.
  • 基因功能参考文献：
    1. Experiments testing the cellular uptake of androgens suggest that testosterone is an excellent substrate of OATP1B3 and cells expressing a doxycycline-inducible SLCO1B3 construct had greater uptake of a clinically relevant concentration of 3H-testosterone . When compared with Slco1b2 (-/-) mice, Slco1b2 (-/-)/hSLCO1B3 knockins had greater greater hepatic uptakeand lower plasma exposure to 3H-testosterone PMID: 28389619
    2. Protection against phalloidin hepatotoxicity by oleanolic acid involves activation of Nrf2 and suppression of Oatp1b2. PMID: 25280775
    3. the combination of NASH-associated decrease in compensatory Oatp transporters and Oatp1b2 genetic loss caused a synergistic increase in pravastatin plasma and tissue concentrations in kidney and muscle PMID: 24613363
    4. These findings showed that deficiency of Oatp1b transporters alters the absorption, distribution, and elimination of hydroxyurea. PMID: 23986199
    5. Oatp1c1 deficiency has an effect on thyroid hormone metabolism and action in the mouse brain PMID: 22294745
    6. This study indicates that Oatp1b2 has a major role in the hepatic uptake of unconjugated bile acids. PMID: 20949553
    7. Cloning of the full coding region of oatp1b2 revealed the presence of two novel splice variants. Interestingly, these splice variants were significantly expressed in organs such as the kidney, but much less in liver. PMID: 19400585
    8. Review summarizes the evidence for the important role of mouse liver-specific organic anion transporting polypeptide Oatpb2 in drug deposition and hepatotoxicity. PMID: 18492796
    9. Report critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp1b2 uptake transporter in mouse liver. PMID: 18703564
    10. In the liver, histone H3 in the proximal promoter of Oatp1b2 is hyperacetylated, whereas acetylation in the kidney and the cerebrum is minimal. PMID: 19047482

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Organo anion transporter (TC 2.A.60) family
  • 组织特异性：
    Liver specific.
  • 数据库链接：

    KEGG: mmu:28253

    STRING: 10090.ENSMUSP00000044326

    UniGene: Mm.272223