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  4. Recombinant Mouse Src-like-adapter 2 (Sla2)

Recombinant Mouse Src-like-adapter 2 (Sla2)

  • 中文名称：
    小鼠Sla2重组蛋白
  • 货号：
    CSB-YP854518MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sla2重组蛋白
  • 货号：
    CSB-EP854518MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sla2重组蛋白
  • 货号：
    CSB-EP854518MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sla2重组蛋白
  • 货号：
    CSB-BP854518MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sla2重组蛋白
  • 货号：
    CSB-MP854518MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sla2
  • Uniprot No.：
  • 别名：
    Sla2; Src-like-adapter 2; Src-like adapter protein 2; SLAP-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-259
  • 氨基酸序列
    GSLSSRGKT SSPSPSSSGP DQEPVSMQPE RHKVTAVALG SFPAGEQARL SLRLGEPLTI ISEDGDWWTV QSEVSGREYH MPSVYVAKVA HGWLYEGLSR EKAEELLLLP GNPGGAFLIR ESQTRRGCYS LSVRLSRPAS WDRIRHYRIQ RLDNGWLYIS PRLTFPSLHA LVEHYSELAD GICCPLREPC VLQKLGPLPG KDTPPPVTVP TSSLNWKKLD RSLLFLEAPA SGEASLLSEG LRESLSSYIS LAEDPLDDA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
  • 基因功能参考文献：
    1. SLAP2 acts as a negative regulator of FLT3 signaling and therefore, modulation of SLAP2 expression levels may provide an alternative therapeutic approach for FLT3-ITD positive acute myeloid leukemia PMID: 27458164
    2. SLAP and SLAP2 are critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke PMID: 25301707
    3. In bone marrow-derived dendritic cells lacking SLAP and closely related SLAP2, downregulation of the granulocyte-macrophage colony-stimulating factor (GM-CSF)beta receptor is impaired. PMID: 21220694
    4. SLAP-2 plays a role in c-Cbl-dependent down-regulation of CSF-1R signaling PMID: 17353186
  • 亚细胞定位：
    Cytoplasm. Cell membrane. Cytoplasmic vesicle. Late endosome. Note=Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.
  • 组织特异性：
    Mainly expressed in immune system. Highly expressed in spleen and thymus and expressed at intermediate levels in lung. Not expressed in liver, heart and brain. Isoform 1 is predominant in lung and spleen, while isoform 2 is predominant in thymus.
  • 数据库链接：

    KEGG: mmu:77799

    STRING: 10090.ENSMUSP00000029164

    UniGene: Mm.29264