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  4. Recombinant Mouse Stanniocalcin-1 (Stc1)

Recombinant Mouse Stanniocalcin-1 (Stc1)

  • 中文名称：
    小鼠Stc1重组蛋白
  • 货号：
    CSB-YP022821MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Stc1重组蛋白
  • 货号：
    CSB-EP022821MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Stc1重组蛋白
  • 货号：
    CSB-EP022821MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Stc1重组蛋白
  • 货号：
    CSB-BP022821MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Stc1重组蛋白
  • 货号：
    CSB-MP022821MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Stc1
  • Uniprot No.：
  • 别名：
    Stc1; Stc; Stanniocalcin-1; STC-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    34-247
  • 氨基酸序列
    VAAQNSA EVVRCLNSAL QVGCGAFACL ENSTCDTDGM YDICKSFLYS AAKFDTQGKA FVKESLKCIA NGITSKVFLA IRRCSTFQRM IAEVQEDCYS KLNVCSIAKR NPEAITEVIQ LPNHFSNRYY NRLVRSLLEC DEDTVSTIRD SLMEKIGPNM ASLFHILQTD HCAQTHPRAD FNRRRTNEPQ KLKVLLRNLR GEGDSPSHIK RTSQESA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
  • 基因功能参考文献：
    1. Latanoprost-induced reduction of intraocular pressure is mediated through the downstream signaling molecule STC-1. When used by itself, STC-1 exhibits ocular hypotensive properties. PMID: 28538979
    2. STC-1 maybe improve anti-inflammation, anti-oxidant and anti-apoptosis activities by affecting reactive oxygen species -mediated pathways, especially the phospho-modifications of the respective proteins, resulting in the increase of Superoxide dismutase and reduce of capase-3, p53, IL-6 and IFN-gamma. PMID: 27420048
    3. STC1 blunts bleomycin-induced rise in thrombin protein and activity, diminishes thrombin-induced signaling through PAR1 to ERK, and inhibits bleomycin-induced pneumonitis. PMID: 26640170
    4. Stanniocalcin 1 is expressed in thyroid side population cells and thyroid cancer cells. PMID: 25647164
    5. Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using Stc1. PMID: 25373521
    6. Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase-dependent pathway. PMID: 25012175
    7. STC1 is an endogenous stress protein that may counteract LPS-induced lung injury by inhibiting the inflammatory cascade and inducing antioxidant and antiapoptotic mechanisms. PMID: 24685991
    8. critical for kidney tubular epithelial survival under physiologic conditions PMID: 24700878
    9. Remarkably, X-linked genes are not overexpressed in female Stc1(-/-) mice, revealing the existence of a mechanism(s) that can compensate for a persistent XCI deficiency to regulate X-linked gene expression. PMID: 25136103
    10. Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury. PMID: 22695329
    11. STC1 was not crucial for the development of ischemic tolerance triggered by hypoxic preconditioning, or for preserving blood-brain barrier integrity but may be involved in functional recovery after stroke. PMID: 23159313
    12. the inner medullary STC-1 gene is differentially regulated in rat and mouse by arginine vasopressin and angiotensin II PMID: 21867741
    13. Vascular endothelial growth factor-D stimulates endothelial cell VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects. PMID: 21474827
    14. STC-1 could have a role in salt and water balance as dehydration necessitates water conservation as well as controlled natriuresis and kaliuresis. PMID: 20540985
    15. the biological repertoires of STCs in mammals will be considerably larger than in fish and may not be limited to mineral metabolism PMID: 11832417
    16. STC1 is expressed in a time- and cell-specific manner and may play an autocrine/paracrine role during osteoblast development and bone formation PMID: 11897801
    17. STC-1 can affect calcium homeostasis, bone and muscle mass and structure, and angiogenesis PMID: 12193584
    18. Data characterize the STC receptor and the functional targeting of ligand and receptor to mitochondria. PMID: 12223480
    19. STC1 may play a selective modulatory role in angiogenesis, possibly serving as a "stop signal" or stabilizing factor contributing to the maturation of newly formed blood vessels PMID: 14500721
    20. role for mammalian STC1 in modulating the immune/inflammatory response in ureteric obstruction PMID: 14570698
    21. kinetics of upregulated STC-1 expression during adipogenesis was investigated in 3T3-LI cells PMID: 15149855
    22. These findings have thus shown that the mammary glands are indeed targeted by STC, even in the virgin state. PMID: 16150955
    23. Stc1 function is not essential for growth or reproduction in the mouse PMID: 16287871
    24. systemically derived STC-1 has important effects on mammary gland development and the transfer of serum-based triglycerides into milk and also has a role in maternal behavior PMID: 16772321
    25. Hypoxic preconditioning leads to neuroprotection through IL-6-mediated upregulation of stanniocalcin-1 expression. PMID: 17272771
    26. IL-6-induced expression of STC-1 is one molecular mechanism behind the ischemic tolerance generated by HOPC in the heart PMID: 17573464
    27. stanniocalcin-1 is a potent anti-inflammatory and renal protective protein. PMID: 19246645
    28. Stc1 acts in a negative feedback loop in the prosurvival ERK1/2 signaling pathway during oxidative stress. PMID: 19347030
    29. Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2. PMID: 19602668
    30. Transgenic overexpression of hSTC1 results in severe post-natal dwarfism (30-50%) indepedent of GH or IGF-I and a reduction female reproductive competence. PMID: 11861508

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Stanniocalcin family
  • 组织特异性：
    Expressed in many tissues.
  • 数据库链接：

    KEGG: mmu:20855

    STRING: 10090.ENSMUSP00000014957

    UniGene: Mm.20911