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  4. Recombinant Mouse Steroid hormone receptor ERR1 (Esrra)

Recombinant Mouse Steroid hormone receptor ERR1 (Esrra)

  • 中文名称：
    小鼠Esrra重组蛋白
  • 货号：
    CSB-YP007834MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Esrra重组蛋白
  • 货号：
    CSB-EP007834MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Esrra重组蛋白
  • 货号：
    CSB-EP007834MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Esrra重组蛋白
  • 货号：
    CSB-BP007834MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Esrra重组蛋白
  • 货号：
    CSB-MP007834MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Esrra; Err1; Estrra; Nr3b1Steroid hormone receptor ERR1; Estrogen receptor-like 1; Estrogen-related receptor alpha; ERR-alpha; Nuclear receptor subfamily 3 group B member 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-422
  • 氨基酸序列
    MSSQVVGIEP LYIKAEPASP DSPKGSSETE TEPPVTLASG PAPARCLPGH KEEEDGEGAG SGEQGSGKLV LSSLPKRLCL VCGDVASGYH YGVASCEACK AFFKRTIQGS IEYSCPASNE CEITKRRRKA CQACRFTKCL RVGMLKEGVR LDRVRGGRQK YKRRPEVDPL PFPGPFPAGP LAVAGGPRKT APVNALVSHL LVVEPEKLYA MPDPASPDGH LPAVATLCDL FDREIVVTIS WAKSIPGFSS LSLSDQMSVL QSVWMEVLVL GVAQRSLPLQ DELAFAEDLV LDEEGARAAG LGDLGAALLQ LVRRLQALRL EREEYVLLKA LALANSDSVH IEDAEAVEQL REALHEALLE YEAGRAGPGG GAERRRAGRL LLTLPLLRQT AGKVLAHFYG VKLEGKVPMH KLFLEMLEAM MD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
  • 基因功能参考文献：
    1. This work reveals a molecular mechanism by which ERRalpha-induced metabolic reprogramming promotes survival of lapatinib-resistant cancer cells. PMID: 27402251
    2. the involvement of ERRalpha in the progression of cisplatin-induced AKI is probably through impaired mitochondrial dynamics PMID: 29545177
    3. Localizing ESRRA binding sites in cortical chromatin, it has been shown that this nuclear receptor binds both differentially expressed energy-related and neurodevelopmental transcription factor genes during social challenge. PMID: 28356321
    4. findings highlight a MYC/ERRalpha pathway that contributes to physiological and pathological bone loss by integrating the MYC/ERRalpha axis to drive metabolic reprogramming during osteoclast differentiation PMID: 28530645
    5. Study performed a structural and functional assessment of glutamatergic synapses on medium spiny neurons in the nucleus accumbens of Esrra-null mice, and discovered sex-specific alterations in miniature excitatory postsynaptic currents frequency and amplitude, reduced paired-pulse ratio, and reduction in glutamatergic synaptic vesicles consistent with altered functional connectivity PMID: 27155145
    6. The nuclear receptor, estrogen-related receptor alpha (ERRalpha), was shown to regulate the expression of genes required for lactate utilization. PMID: 27050525
    7. In bone, the effects of cholesterol, statin, and bisphosphonate on osteoclastogenesis require ERRalpha; and consequently, cholesterol-induced bone loss or bisphosphonate osteoprotection is lost in ERRalpha knockout mice. PMID: 26777690
    8. We conclude that E2-induced ERRalpha expression in endothelium plays an important role for the E2-induced vasculoprotective effect PMID: 26271712
    9. These results indicate that Esrra deficiency in the mouse brain impairs behavioral responses in multiple functional domains. PMID: 25865889
    10. Suppressed feeding behavior in novelty stress-exposed aged male mice may be mediated by 5-HT(2C)R hypersensitivity, leading to hypoghrelinemia. The hypersensitivity may partly be due to estrogen receptor activation in aged male mice. PMID: 25732068
    11. study shows that ERRalpha plays a key role in directing transcriptional programs required for optimal mitochondrial oxidative potential and muscle fitness PMID: 25361393
    12. Mice lacking both ERRalpha and cardiac Errg develop severe bradycardia, lethal cardiomyopathy, and heart failure featuring metabolic, contractile, and conduction dysfunctions. PMID: 25624346
    13. This study shows that in C2C12 myotubes Ndrg2 is a novel PGC-1alpha/ERRalpha transcriptional target. PMID: 24008097
    14. Loss of estrogen-related receptor alpha promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances. PMID: 24127579
    15. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor alpha (ERRalpha). PMID: 23836899
    16. ERRa-dependent control of metabolic gene programs is rapamycin sensitive, strategies aimed at enhancing rather than repressing ERRa activity appear to be a viable therapeutic avenue to relieve hepatic hyperlipidemia and steatosis. PMID: 23562079
    17. conclude that the late (maturation), but not early (commitment), negative effects of ERRalpha on the osteoblast lineage contribute to the reduced bone mineral density observed upon estrogen deficiency PMID: 23359549
    18. the repressive effect of NCoR1 on oxidative phosphorylation gene expression specifically antagonizes PGC-1alpha-mediated coactivation of ERRalpha PMID: 23028049
    19. Suppression of ERalpha expression in the medial preoptic area almost completely abolished maternal care. PMID: 22988120
    20. the 50-flanking region of the Cact gene contains a consensus sequence for ERRalpha. This sequence binds ERRa both in vivo and in vitro and is required for the activation of Cact expression by the PGC-1/ERR axis PMID: 22713466
    21. Data identify ERRalpha as a new regulator of the Wnt-signaling pathway during osteoblast differentiation, through a cell-intrinsic mechanism not affecting beta-catenin nuclear translocation. PMID: 22333182
    22. ERRalpha is a selective transcriptional regulator of Teff metabolism that may provide a metabolic means to modulate immunity PMID: 22042850
    23. ERRalpha is required for normal skeletal myocyte differentiation via modulation of MAP kinase signaling. PMID: 21562305
    24. ERRalpha in 3T3-L1 adipocytes reduces mitochondrial biogenesis but enhances glycolysis and basal glucose uptake PMID: 18544047
    25. PGC-1alpha, ERRalpha, and mitofusin 2 may be important factors in the process of denervation-induced mitochondrial adaptation PMID: 21394548
    26. ERRalpha regulates the diurnal expression of core clock and clock-controlled genes in the liver. PMID: 21731503
    27. a novel function for ERK8 as a bona fide ERRalpha corepressor, involved in control of its cellular localization by nuclear exclusion, and suggest a key role for this MAP kinase in the regulation of the biological activities of this nuclear receptor. PMID: 21190936
    28. Data show that the impairment of ERRalpha function does not alter osteoclasts precursor proliferation and differentiation but does alter the adhesion/spreading and migration capacities of mature OCs. PMID: 20841427
    29. Results show that ERRalpha is an acetylated protein and imply the existence of a dynamic acetylation/deacetylation switch involved in the control of ERRalpha transcriptional activity. PMID: 20484414
    30. these data propose a positive role for ERRalpha in osteoblastic and adipocytic differentiation. PMID: 20417614
    31. ERRalpha has a role in bone loss induced by age or estrogen-deficiency PMID: 19936213
    32. ERRaKO female mice are resistant to ovariectomy-induced bone loss PMID: 19936213
    33. Prox1 interacts with ERRalpha and PGC-1alpha, occupies promoters of metabolic genes on a genome-wide scale, and inhibits the activity of the ERRalpha/PGC-1alpha complex PMID: 20194433
    34. Data from genomic studies using male ERRalpha knockout mice suggest role of ERRalpha as pleiotropic regulator of renal control of blood pressure, renal Na+/K+ homeostasis, and renin-angiotensin pathway. PMID: 19901197
    35. Differential ER effects on growth and development in various estrogen-responsive tissues. Findings suggest that nonclassical ER signaling pathways play an important physiological role in the development and function of the reproductive system. PMID: 12351685
    36. Transcriptionlal activation driven by the PPARalpha/RXRalpha complex was counteracted by the expression of ERR1 in HeLa cells. PMID: 12914524
    37. ERRalpha-/- mice are viable, fertile and display no gross anatomical alterations, with the exception of reduced body weight and peripheral fat deposits. PMID: 14585956
    38. Erralpha and GA-binding protein a partner with PGC-1alpha in muscle to form a double-positive-feedback loop that drives the expression of many oxidative phosphorylation genes PMID: 15100410
    39. expression of ERRalpha displays a circadian rhythmicity in liver, bone and uterus PMID: 15291745
    40. results demonstrate that apoA-IV is a direct ERRalpha target gene and suggest a function for ERRalpha in intestinal fat transport, a crucial step in energy balance PMID: 15466464
    41. ERRalpha and MCAD are markedly reduced in the liver, heart, and kidney of mice during the lipopolysaccharide-induced acute phase response. PMID: 16061943
    42. ERRalpha activity could have beneficial effects on glucose metabolism in diabetic subjects by two distinct mechanisms: increasing mitochondrial oxidative capacity in peripheral tissues and liver, and suppressing hepatic glucose production PMID: 16267049
    43. PGC-1alpha expression in skeletal muscle coordinately upregulate the expression of pyruvate dehydrogenase kinase 4 (PDK4) via the orphan nuclear receptor ERRalpha PMID: 16314495
    44. estrogen-related receptor alpha functions through a novel binding site on the Ucp1 enhancer PMID: 17456798
    45. ERRs orchestrate a comprehensive genome-wide cardiac transcriptional program. PMID: 17488637
    46. ERRalpha may play a critical role in adipocyte differentiation by modulating the expression of various adipogenesis-related genes PMID: 17512501
    47. Rb1cc1 is a target gene of ERRalpha, driven by a novel type of recognition sequence. PMID: 18039682
    48. study reports age- and sex-specific interaction of estrogen receptor alpha-transactivation domain with p68 RNA helicase; age- and sex-specific interaction of p68 suggests its implication in ERalpha-mediated brain functions during aging PMID: 19025768
    49. The up-regulation of ERRalpha might be related to tumor growth and advancement in uterine endometrial cancers. PMID: 19416752
    50. Adult female and male ERRalpha-deficient mice displayed a moderate increase in femoral cancellous bone volume and density; osteoblast surface was increased and marrow fat volume decreased in these animals. PMID: 19608650

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Nuclear hormone receptor family, NR3 subfamily
  • 组织特异性：
    Most highly expressed in kidney, heart, and brown adipocytes. Also found in uterus, cervix and vagina.
  • 数据库链接：

    KEGG: mmu:26379

    STRING: 10090.ENSMUSP00000025906

    UniGene: Mm.386776