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  4. Recombinant Mouse Stomatin-like protein 3 (Stoml3), partial

Recombinant Mouse Stomatin-like protein 3 (Stoml3), partial

  • 中文名称：
    小鼠Stoml3重组蛋白
  • 货号：
    CSB-YP757632MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Stoml3重组蛋白
  • 货号：
    CSB-EP757632MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Stoml3重组蛋白
  • 货号：
    CSB-EP757632MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Stoml3重组蛋白
  • 货号：
    CSB-BP757632MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Stoml3重组蛋白
  • 货号：
    CSB-MP757632MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Stoml3
  • Uniprot No.：
  • 别名：
    Stoml3; Sro; Stomatin-like protein 3; SLP-3; Stomatin-related olfactory protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.
  • 基因功能参考文献：
    1. STOML3 inhibitors in the skin also reversibly attenuate fine touch perception in normal mice. PMID: 27941788
    2. In C57BL/6N, but not STOML3(-/-) mice, tactile allodynia is attenuated by cholesterol depletion, suggesting that membrane stiffening by STOML3 is essential for mechanical sensitivity. PMID: 26443885
    3. STOML3 is the first potent modulator of Piezo channels that tunes the sensitivity of mechanically gated channels to detect molecular-scale stimuli relevant for fine touch. PMID: 24662763
    4. Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons. PMID: 22773952
    5. [review] Generation of stoml3-deficient mice demonstrates that murine STOML3 is functionally orthologous to the MEC-2 memrane protein. PMID: 21501885
    6. characterization of an olfactory neuronal protein, SLP3, which shares extensive homology with the stomatin family of membrane proteins; expressed selectively in the receptor neurons of the olfactory epithelium PMID: 12239636
    7. SLP3 is therefore indispensable for the function of a subset of cutaneous mechanoreceptors, and our data support the idea that this protein is an essential subunit of a mammalian mechanotransducer PMID: 17167420

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  • 亚细胞定位：
    Cell membrane; Single-pass type III membrane protein. Note=Detected in lipid rafts, in apical dendrites and in olfactory cilia.
  • 蛋白家族：
    Band 7/mec-2 family
  • 组织特异性：
    Expressed by all dorsal root ganglion neurons and is selectively expressed in neuronal tissues. Detected in olfactory epithelium.
  • 数据库链接：

    KEGG: mmu:229277

    STRING: 10090.ENSMUSP00000029307

    UniGene: Mm.222810