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  4. Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 4 (Timd4), partial

Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 4 (Timd4), partial

  • 中文名称：
    小鼠Timd4重组蛋白
  • 货号：
    CSB-YP747606MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Timd4重组蛋白
  • 货号：
    CSB-EP747606MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Timd4重组蛋白
  • 货号：
    CSB-EP747606MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Timd4重组蛋白
  • 货号：
    CSB-BP747606MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Timd4重组蛋白
  • 货号：
    CSB-MP747606MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Timd4
  • Uniprot No.：
  • 别名：
    Timd4; Tim4; T-cell immunoglobulin and mucin domain-containing protein 4; TIMD-4; Spleen; mucin-containing; knockout of lymphotoxin protein; SMUCKLER; T-cell immunoglobulin mucin receptor 4; TIM-4; T-cell membrane protein 4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1.
  • 基因功能参考文献：
    1. These results indicate that TAM and Tim4 collaborate for efficient efferocytosis in certain macrophage populations. PMID: 28768810
    2. TIM-4 is expressed on iNKT cells but dispensable for their development and function. PMID: 27662666
    3. TIM-4 was differentially expressed in the distinct subsets of DCs in skin and skin-draining LNs, and specifically regulated epidermal LC and LN CD207-CD4+ DC homeostasis PMID: 27224924
    4. identified TIM-4 as a novel marker for B effector 1 (Be1) cells that depend on IFN-gamma for their proinflammatory activity; TIM-4(+) B cells are enriched for IFN-gamma-producing proinflammatory Be1 cells that enhance immune responsiveness and can be specifically targeted with anti-TIM-4. PMID: 28848066
    5. Oral treatment with the mucosal adjuvant cholera toxin (CT) induces expression of T cell immunoglobulin and mucin domain containing 4 (TIM-4) on a proportion of CD103+ CD11b+ dendritic cell (DC) in the intestinal lamina propria (LP). PMID: 27379516
    6. attenuated LPS-induced endotoxic shock by inhibiting cytokine production by macrophages PMID: 27617399
    7. analysis of the molecular characteristics of both mTIM-4 and hTIM-4 provides a better understanding of the regions of the TIM-4 IgV domain critical for Ebola virus entry PMID: 27122575
    8. STAT6 mediates the CT-induced TIM4 expression in DCs. In conclusion, p300 and STAT6 mediate the microbial product CT-induced TIM4 expression in DCs. PMID: 26899911
    9. Blockade of Tim-4 aggravates atherosclerosis in LDL receptor knockout mice likely by prevention of phagocytosis of phosphatidylserine-expressing apoptotic cells and activated T cells by Tim-4-expressing cells. PMID: 26821944
    10. results indicate that Tim-4 is involved in negative regulation of NO production in macrophages, suggesting the critical role of Tim-4 in immune related diseases PMID: 25905790
    11. TIM-4 on dendritic cells plays a critical role in hepatic ischemia-reperfusion (IR) injury and may be an efficient target for the prevention of liver or other organ IR injuries. PMID: 25771178
    12. M2-like TIM-4hiCD169+ tissue-resident macrophages are immunoregulatory and promote engraftment of cardiac allografts, but their influence is diminished by TIM-4-dependent programmed cell death PMID: 24983317
    13. intrinsic macrophage-specific TIM-4 signaling has indispensable role in innate immunity-driven liver ischemia-reperfusion injury PMID: 25066922
    14. TIM4 engages integrins as coreceptors to evoke the signal transduction needed to internalize PtdSer-bearing targets such as apoptotic cells. PMID: 24623723
    15. Tim-4 expression was higher in Behcet's disease (BD) mice than that in BDN mice. PMID: 24453431
    16. In addition to the known phosphatidylserine(PS) binding pocket, Tim4 has four weaker sites of interaction, making it sensitive to PS surface concentration in a manner capable of differential recognition on the basis of PS exposure level. PMID: 24706780
    17. the engulfment of apoptotic cells by resident peritoneal macrophages proceeds in two steps: binding to Tim4, a PtdSer receptor, followed by MerTK-mediated cell engulfment PMID: 24515440
    18. Data suggest that trans-membrane (or T cell) immunoglobulin and mucin (TIM) molecules are expressed in embryonic hematopoietic tissues in chicken and mouse and that in fetal liver, TIM-4 is expressed by myeloid progenitor cells. PMID: 24316337
    19. TIM-4 directly interacted with AMPKalpha1 and activated autophagy-mediated degradation of ingested tumors, leading to reduced antigen presentation and impaired CTL responses PMID: 24315994
    20. The therapeutic effect of anti-TIM-4 mAb on arthritis is mediated by the inhibition of proinflammatory cytokine production by inflammatory cells, osteoclast differentiation, and bone resorption. PMID: 24068667
    21. In RAG(-/-) recipients of skin allografts adoptively transferred with CD4( ) T cells, findings show that TIM-4 blockade in vivo is associated with a 3-fold prolongation in allograft survival. PMID: 24038092
    22. TIM-4-mediated clearance of antigen specific T cells represents an important previously unrecognized mechanism regulating respiratory tolerance. PMID: 23149665
    23. aged female mice deficient in both MFG-E8 and Tim4 developed autoantibodies in an age-dependent manner PMID: 22723547
    24. Wild type TIM-4, a receptor for phosphatidylserine (a marker of apoptotic cells) regulates adaptive immunity in part by mediating the removal of antigen-specific T cells during the contraction phase of the response. PMID: 21037090
    25. These data support an indispensible role of Tim-4 in maintaining the homeostasis of resident peritoneal macrophages. PMID: 20421466
    26. TIM-4 is critical for the clearance of apoptotic bodies in vivo, and that lack of TIM-4 results in aberrant persistence of apoptotic bodies leading to dysregulated lymphocyte activation and signs of systemic autoimmunity. PMID: 20368430
    27. TIM-1-TIM-4 interaction is involved in regulating T cell proliferation. PMID: 15793576
    28. results indicate that Tim4 and Tim1 are phosphatidylserine receptors for the engulfment of apoptotic cells, and may also be involved in intercellular signalling in which exosomes are involved PMID: 17960135
    29. Tim-4, expressed on APCs, is a costimulatory molecule that promotes T cell expansion and survival by cross-linking Tim-1 on T cells PMID: 18354194
    30. results suggest that TIM-4 exerts bimodal functions depending on the activation status of T cells PMID: 18367551
    31. concurrent exposure to cholera toxin (CT) & peanut extract (PE) increases TIM4 expression in dendritic cells(DC)& promotes DC maturation, which plays an important role in initiation of PE-specific T(H)2 polarization &allergy in the intestine PMID: 18547633

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, TIM family
  • 组织特异性：
    Predominantly expressed in lymphoid tissues, such as spleen, lymph nodes, and Peyer patches. Also expressed in fetal liver, salivary gland, and spleen stromal cells, predominantly in the marginal zone and to a lesser extent throughout the white pulp. Not
  • 数据库链接：

    KEGG: mmu:276891

    STRING: 10090.ENSMUSP00000069456

    UniGene: Mm.69002