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  4. Recombinant Mouse TIR domain-containing adapter molecule 2 (Ticam2)

Recombinant Mouse TIR domain-containing adapter molecule 2 (Ticam2)

  • 中文名称：
    小鼠Ticam2重组蛋白
  • 货号：
    CSB-YP806390MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ticam2重组蛋白
  • 货号：
    CSB-EP806390MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ticam2重组蛋白
  • 货号：
    CSB-EP806390MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ticam2重组蛋白
  • 货号：
    CSB-BP806390MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ticam2重组蛋白
  • 货号：
    CSB-MP806390MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ticam2
  • Uniprot No.：
  • 别名：
    Ticam2; Tirp; Tram; TIR domain-containing adapter molecule 2; TICAM-2; TRIF-related adapter molecule; Toll/interleukin-1 receptor domain-containing protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-232
  • 氨基酸序列
    GVGKSKLDK CPLSWHKKDS VDADQDGHES DSKNSEEACL RGFVEQSSGS EPPTGEQDQP EAKGAGPEEQ DEEEFLKFVI LHAEDDTDEA LRVQDLLQND FGIRPGIVFA EMPCGRLHLQ NLDDAVNGSA WTILLLTENF LRDTWCNFQF YTSLMNSVSR QHKYNSVIPM RPLNSPLPRE RTPLALQTIN ALEEESQGFS TQVERIFRES VFERQQSIWK ETRSVSQKQF IA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response. Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria.
  • 基因功能参考文献：
    1. Using ovalbumin as model antigen, the s showed that exposure of dendritic cells to hyperosmolarity strongly inhibits activation of antigen-specific T cells despite enhancement of antigen uptake, processing and presentation. They identified TRIF as key mediator of this phenomenon. PMID: 28331179
    2. the present study indicated that MyD88 and TRIF blockades serve notable and equivalent roles in protecting cardiac deterioration from severe sepsis by attenuating cytokine release, reducing neutrophil infiltration and alleviating apoptosis. PMID: 29115392
    3. lipopolysaccharide (LPS) application induces proliferation of dormant hematopoietic stem cells (HSC) and impairs HSC self-renewal via TLR4-TRIF-ROS-p38 signaling. PMID: 28736216
    4. These results indicate a critical role for Ticam2 in SARS-CoV disease, and highlight the importance of host genetic variation in disease responses. PMID: 28592648
    5. Distinct mechanisms downstream of TLR4 signaling mediate myelosuppression and hematopoietic stem cell exhaustion during sepsis through unique effects of MyD88 and TRIF. PMID: 27264973
    6. these data show that both Myd88 and TRIF are necessary for Th17 differentiation in the lungs in response to immunization with lipopolysaccharide PMID: 27328989
    7. Stimulation of the TLR4-TRIF pathway can protect against the development of allergic airway disease and that a TRIF-dependent adjuvant effect on CD4(+) ICOS(+) T-cell responses may be a contributing mechanism. PMID: 28502093
    8. Monophosphoryl lipid A stimulation of a TLR4-TRIF-PI3K-Akt pathway prevents lipopolysaccharide-induced ERK activation in the medullar thick ascending limb. PMID: 28356284
    9. study reporst a key role for TNF/TNFR1 in Yersinia-induced cell death of murine macrophages, which occurs despite the blockade of NF-kappaB and MAPK signaling imposed by Yersinia on infected cells PMID: 27733552
    10. the role of Toll-like receptor (TLR) 2, TLR4, myeloid differentiation response gene 88, and Toll-IL-1 receptor domain-containing adaptor-inducing interferon-gamma (TRIF), factors critically involved in the TLR signaling pathway, was studied in experimental autoimmune neuritis. PMID: 27842213
    11. Juniperus rigida Sieb. extract inhibits macrophage inflammatory responses by attenuating TRIF-dependent signaling and inflammasome activation. PMID: 27260408
    12. TRIF mediates antibacterial defense during Gram-negative pneumonia, at least in part, by inducing IFN-x03B3; at the primary site of infection. PMID: 26065469
    13. MMP-12 up-regulation mediated by SARM-TRIF signaling pathway contributes to IFN-gamma-independent airway inflammation and AHR post RSV infection in nude mice. PMID: 25652021
    14. HMGB1 and its downstream TLR4/Myd88/TRIF signaling pathway play important roles in the mouse intestinal I/R injury. PMID: 26217083
    15. TLR4, TRIF, and MyD88 mediate the intraocular inflammatory response in endophthalmitis caused by Bacillus cereus. PMID: 26195555
    16. TRIF is a mediator of the innate and adaptive immune interactions in the protective properties of memory immunity against Gram-negative bacteria. PMID: 26351279
    17. Inhibitory effects of SP were mediated through the regulation of TRIF-dependent signaling. PMID: 25747147
    18. These findings indicate that a balanced immune response operating through both TRIF-driven and MyD88-driven pathways likely provides the most effective host cell intrinsic antiviral defense responses to severe SARS-CoV disease PMID: 26015500
    19. TIR-domain-containing adapter-inducing interferon-beta (TRIF) regulates Th17-mediated intestinal immunopathology in colitis PMID: 25073675
    20. TRIF promotes angiotensin II-induced cross-talk between fibroblasts and macrophages in atrial fibrosis. PMID: 26056004
    21. MyD88 and TRIF pathways differently regulate TLR4-induced immune responses in B cells. PMID: 25448706
    22. Data suggest that both TIR-domain-containing adapter-inducing interferon-beta (TRIF) and myeloid differentiation factor 88 (MyD88) are essential for the activation and maturation of dendritic cells in response to Mycobacterium tuberculosis Hsp70 (Mtb Hsp70). PMID: 25461391
    23. role in development of Th17 immunity in neutrophilic asthma PMID: 24985082
    24. Type I interferon has a role in the bias that Toll-like receptor 4 exhibits for signaling mediated by the adaptor protein TRIF PMID: 25389373
    25. HIS exerted potent anti-inflammatory effects via the regulation of TRIF-dependent signaling. PMID: 25689174
    26. TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis. PMID: 25548220
    27. a previously unknown function of the DDX21-TRIF-S100A9-TLR4-MyD88 signaling network in regulating inflammation during infection. PMID: 24391503
    28. PTX3 binds MD-2 and promotes TRIF-dependent immune protection in aspergillosis. PMID: 25049357
    29. SARM expression was reduced and TRIF expression was increased after respiratory syncytial virus infection. PMID: 24478430
    30. neither the unfolded protein response transcription factors XBP1 and CHOP nor the TLR4 adaptor molecule MyD88 is necessary for caspase-8 activation. Instead, both caspase activation and IL-1beta production require the alternative TLR4 adaptor TRIF. PMID: 24489101
    31. a critical role for Arf6 in regulating Tram/Trif-dependent TLR4 signaling. PMID: 24297182
    32. Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain. PMID: 24194546
    33. data indicate that LDL affects the TNF-alpha and IL-6 response of macrophages to P. gingivalis challenge and that MyD88 and TRIF play important roles in P. gingivalis-elicited foam cell formation. PMID: 23194377
    34. signaling through the TLR4 and TRIF pathways limits skin barrier dysfunction, cutaneous allergic sensitization, and proinflammatory cytokine production. PMID: 23997219
    35. Both TRIF and IPS-1 adaptor proteins contribute to the cerebral innate immune response against herpes simplex virus 1 infection. PMID: 23596298
    36. Palmitate & lipopolysaccharides led to a macrophage death pathway requiring TLR4 signaling via TRIF but independent of NF-kappaB, MAPKs, and IRF3. PMID: 23275600
    37. involvement in liver reperfusion injury not found PMID: 22911673
    38. TRIF plays a modest role in protection from Sindbis-induced neurologic disease. PMID: 23084425
    39. IgG class switch was mediated by TIR-domain-containing adapter inducing interferon-beta (TRIF), but not by MyD88. PMID: 23144170
    40. MyD88- and TRIF-dependent signaling has a differential contribution to host defense in different cell types that changes from early- to late-stage gram-negative pneumonia. PMID: 22904341
    41. Caspase-11 activation via the TLR4-TRIF-IFNbeta pathway synergizes with the NLRP3 pathway to coordinate caspase-1-dependent IL-1beta and IL-18 secretion and also leads to caspase-1-independent cell death. PMID: 22819539
    42. This study reveals a central role of MyD88 and a counterregulatory function of TRIF in T cell-driven arthritis. PMID: 22147588
    43. This study indicated that TRIF deficiency promotes ON axon regeneration by attenuating microglial activation and consequently reducing the release of harmful cytokines via NF-kappaB inactivation. PMID: 22361049
    44. TLR2 and TRIF are two critical components leading to the induction of the IFN-beta gene during Listeria infection. PMID: 22432012
    45. The findings of the present study establish the importance of cardiac-specific TRIF-mediated signaling in the heart in acute viral myocarditis PMID: 21956162
    46. Results highlight a critical role for TLR4 and TRIF-IRF3 signaling as the governing mechanism in the neuroprotective response to stroke. PMID: 21999375
    47. The mechanism of TRIF-mediated protective immunity appears to be orchestrated by macrophage-induced IFN-beta and NK cell production of IFN-gamma. PMID: 22124111
    48. gene knock-out mice develope worse acute and chronic CVB3 myocarditis with elevated levels of IL-33 PMID: 22013485
    49. TRIF adaptor protein acts as a potent negative regulator of TLR agonist-triggered immune responses. PMID: 21760953
    50. These data indicate distinct roles for MyD88 and Trif in IR-induced inflammation and suggest that chronic, undetected infections, such as Helicobacter, alter the use of the adaptor proteins to induce damage. PMID: 21056969

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  • 亚细胞定位：
    Cytoplasm. Golgi apparatus. Cell membrane. Early endosome. Late endosome. Endoplasmic reticulum. Cell projection, phagocytic cup.
  • 数据库链接：

    KEGG: mmu:225471

    STRING: 10090.ENSMUSP00000066239

    UniGene: Mm.149280