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  4. Recombinant Mouse Testis-specific Y-encoded-like protein 2 (Tspyl2)

Recombinant Mouse Testis-specific Y-encoded-like protein 2 (Tspyl2)

  • 中文名称：
    小鼠Tspyl2重组蛋白
  • 货号：
    CSB-YP745879MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tspyl2重组蛋白
  • 货号：
    CSB-EP745879MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tspyl2重组蛋白
  • 货号：
    CSB-EP745879MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tspyl2重组蛋白
  • 货号：
    CSB-BP745879MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tspyl2重组蛋白
  • 货号：
    CSB-MP745879MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tspyl2
  • Uniprot No.：
  • 别名：
    Tspyl2; Cinap; Dentt; DXBwg1396e; Tspx; Testis-specific Y-encoded-like protein 2; TSPY-like protein 2; CASK-interacting nucleosome assembly protein; Differentially-expressed nucleolar TGF-beta1 target protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-677
  • 氨基酸序列
    MDRPDEGPPA KTPRLSSSEP RQRDLPPPPP PPLQRLPLPP PQQRPRPQEE TEAAQVLADM RGVGPTLPPP LPYVILEEGG IRAYFTLSAE SPGWDHAMES GFGEAPSTGI METLPSSEIS GGSLAIDFQV AEPSSLGEKA LETCSLGGWG PQMLVGPKRK EEAIIIVEDE DEDDKESVRR RQRRRRRRRK QRKAKESRER SAQRMESILQ ALESIQMDLE AVNIKAGKAF LRLKRKFIQM RRPFLERRDL IIQHIPGFWV KAFLNHPRIS ILINQRDRDI FRYLTNLQVQ DLRHISMGYK MKLYFQTNPY FTNMVIVKEF QRNRSGRLVS HSTPIRWHRG QEPQAYNRRS HDTRESFFNW FSNHSLPEAD RIAEIIKNDL WVNPVRYYMR RGGYRSSRKK QHGKERAKNQ YEMVIMEDAH DHYAIEDILS DISEIDEITD NETIHDIKIS DFMETTDYFE TTDNEVTDAN ENLCDSENPD HSEGYNTKIT DNKGSVAANP DDNSDDPEEK NTYDSEDSNS EKADGDNTTL RDNQQVTNIQ DSSDSDNGDE GSDDEDDDGN EGDNEGSDDD DDDNEGSDDD DRDIRYYKNG PEVFDKALDN RTNQNDYEEE VELISEDSVE EEEETSEEAS QLSEDSYEDE RIYGEERSEV NSEDSDIQEV LPVPKAWASL GKKGKIG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
  • 基因功能参考文献：
    1. Homozygous CINAP-/- mice show embryonic lethality. The heterozygotes are viable and show defects in 18S rRNA processing. PMID: 27477389
    2. The identification that diabetes is associated with upregulation of vascular CDA1 and that CDA1 deletion in diabetic mice promotes aneurysm formation provides evidence that CDA1 plays a role in diabetes to reduce susceptibility to aneurysm formation. PMID: 29311219
    3. These findings suggest that disrupting Tspyl2 gene expression leads to behavioral and brain morphological alterations that mirror a number of neurodevelopmental psychiatric traits. PMID: 26826030
    4. Following infection with T. gondii, myotubes but not myoblasts or fibroblasts further upregulate the negative cell cycle regulator Tspyl2. PMID: 25131712
    5. We conclude that TSPYL2 contributes to cognitive variability through regulating the expression of Grin2a and Grin2b. PMID: 24413569
    6. CDA1 deletion reduces but does not block renal TGF-beta signaling. PMID: 23929772
    7. TSPYL2 serves a biological role in maintaining the G1 checkpoint under stress condition. PMID: 21738728
    8. DENTT may play a role in development of the endocrine tissues, nervous system, lung, oocytes, and thecal cells, and testis [DENTT] PMID: 12112471
    9. DENTT may play multiple roles in modulating transcriptional responses suggesting new roles for the TTSN superfamily during embryogenesis and differentiation. PMID: 12619135
    10. Mice treated with hypertonic saline expressed higher CINAP protein levels in the PVN, supporting a role of CINAP in neural response in vivo. PMID: 16374801

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons.
  • 蛋白家族：
    Nucleosome assembly protein (NAP) family
  • 组织特异性：
    Present at high levels in the pituitary gland and at moderate levels in adrenal gland, brain, testis and ovary. In brain, expressed both in mature neurons and progenitor cells (at protein level).
  • 数据库链接：

    KEGG: mmu:52808

    STRING: 10090.ENSMUSP00000046782

    UniGene: Mm.9997