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  4. Recombinant Mouse Testis-specific serine/threonine-protein kinase 1 (Tssk1b)

Recombinant Mouse Testis-specific serine/threonine-protein kinase 1 (Tssk1b)

  • 中文名称：
    小鼠Tssk1b重组蛋白
  • 货号：
    CSB-YP723405MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tssk1b重组蛋白
  • 货号：
    CSB-EP723405MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tssk1b重组蛋白
  • 货号：
    CSB-EP723405MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tssk1b重组蛋白
  • 货号：
    CSB-BP723405MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tssk1b重组蛋白
  • 货号：
    CSB-MP723405MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tssk1b
  • Uniprot No.：
  • 别名：
    Tssk1b; Stk22a; Tssk1; Testis-specific serine/threonine-protein kinase 1; TSK-1; TSK1; TSSK-1; Testis-specific kinase 1; EC 2.7.11.1; Serine/threonine-protein kinase 22A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-365
  • 氨基酸序列
    MDDAAVLKRR GYIMGINLGE GSYAKVKSAY SERLKFNVAV KIIDRKKAPS DFLEKFLPRE IEILAMLNHR SIVKTYEIFE TSDGKVYIVM ELGVQGDLLE FIKTRGALQE DDARKKFHQL SSAIKYCHDL DVVHRDLKCE NLLLDKDFNI KLSDFGFSKR CLRDDSGRLI LSKTFCGSAA YAAPEVLQGI PYQPKVYDIW SLGVILYIMV CGSMPYDDSN IKKMLRIQKE HRVNFPRSKH LTGECKDLIY RMLQPDVNRR LHIDEILNHC WVQPKARGLS SGAINKEGES SRATEPSWIP EPGADKKSAT KLEPREEARS EARSESKPQE DTLQVVRQSE NVGLSSELNR DTEEGHPQQP SETHT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-281' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.
  • 基因功能参考文献：
    1. In mouse testis, PPP1CC2 can form a complex with TSSK1 mediated by the direct interaction of each with the kinase substrate protein TSKS. Interaction between PPP1CC2 and TSKS is mediated through an RVxF docking motif on the TSKS surface. PMID: 24088291
    2. HSP90 function abolished the catalytic activities of TSSK4 and -6 but did not significantly alter the specific activities of TSSK1 and -2. Inhibition of HSP90 resulted in increased TSSK ubiquitination and proteasomal degradation PMID: 23599433
    3. Tssk1 and Tssk2 play an important role in the regulation of sperm function. PMID: 22855445
    4. Results reveal TSSK1- and TSSK2-dependent functions of a transformed chromatoid body in post-meiotic cytodifferentiation of spermatids. PMID: 20053632
    5. The expression patterns of Tsk1 is documented throughout spermiogenesis showing an initial association of Tsk1 with cells in meiotic metaphase. PMID: 9651519
    6. Deletion of Tssk2 kinase/substrate pair is predicted to play an indispensable role during spermiogenesis PMID: 18495105
    7. Results confirm both TSSK 2 and TSKS persist in sperm, define a critical role of TSKS' N-terminus in enzyme interaction, identify Ser 281 as a TSKS phosphorylation site and indicate an indispensable role for TSSK 1 and 2 in spermiogenesis. PMID: 18533145

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  • 亚细胞定位：
    Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. Note=In spermatozoa, present in the sperm head and in the flagellum.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family
  • 组织特异性：
    Testis-specific. Expressed only in postmeiotic spermatids at the final stages of cytodifferentiation in the seminiferous tubules (at protein level). Not detected in released sperms in the lumen of the seminiferous tubules and the epididymis.
  • 数据库链接：

    KEGG: mmu:22114

    STRING: 10090.ENSMUSP00000040302

    UniGene: Mm.439725