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  4. Recombinant Mouse Thymus-specific serine protease (Prss16)

Recombinant Mouse Thymus-specific serine protease (Prss16)

  • 中文名称：
    小鼠Prss16重组蛋白
  • 货号：
    CSB-YP889553MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Prss16重组蛋白
  • 货号：
    CSB-EP889553MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Prss16重组蛋白
  • 货号：
    CSB-EP889553MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Prss16重组蛋白
  • 货号：
    CSB-BP889553MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Prss16重组蛋白
  • 货号：
    CSB-MP889553MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Prss16
  • Uniprot No.：
  • 别名：
    Prss16; Tssp; Thymus-specific serine protease; EC 3.4.-.-; Serine protease 16
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-509
  • 氨基酸序列
    ALLLRRLR EHIQKFQESS SLHPGFGLGH GPGAVPKQGW LEQPLDPFNA SDRRTFLQRY WVNDQHRTGQ DVPVFLHIGG EGSLGPGSVM AGHPAALAPA WGALVISLEH RFYGLSMPAG GLDLALLRYL SSRHALADVA SARQALSGLL NVSSSSPWIC FGGSYAGSLA TWARLKFPHL VFAAVASSAP LSAVVDFSAY NQVVARSLTQ VAIGGSLECL AAASTAFTEV ERLLRAGPAA QAVLREELGA CGSLDLTEDQ AELLGALQAL VGGTVQYDGQ AGAPLSVRQL CGLLLGKWGN RSRSTPYLGL RRAVQIVLRS MGQKCLSFSR AETVAQLSNT EPQVSGVGDR QWLYQTCTEF GFYVTCEGLQ CPFSQLPALP FQLELCEQVF GLSPASVAQA VAQTNSYYGG QSPGATQVLF VNGDTDPWHV LSVTQDLGLS EPALLIPSAS HCFDMAPMRP SDSPSLRLGR QKISQQLQDW LKDIKKSQS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Protease that may play a role in T-cell development.
  • 基因功能参考文献：
    1. these results show that TSSP increases experimental autoimmune encephalomyelitis severity by limiting central tolerance to myelin oligodendrocyte glycoprotein PMID: 29061767
    2. Data indicate that T-cell receptors that react to chromogranin A (ChgA) and islet amyloid polypeptide precursor (IAPP) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP). PMID: 26209627
    3. our data demonstrate that antitumoral immune surveillance requires thymic TSSP-driven production of CD4(+) T cells contributing to inflammatory balance. PMID: 25543139
    4. The differential thymic expression of 4,500 mRNAs of wild-type (WT) C57BL/6 mice with their respective Prss16-knockout (KO) mutants by using microarrays, was analyzed. PMID: 21773946
    5. Tssp is a critical regulator of diabetes development through the selection of the autoreactive CD4 T cell repertoire PMID: 21505262
    6. suggesting that TSSP is necessary for the intrathymic development of cells expressing these T cell receptors PMID: 21173102
    7. role of Prss16 in T-cell development and susceptibility to autoimmunity in the mouse PMID: 12144812
    8. Data suggest that Prss16 is not required for quantitatively normal T-cell development. PMID: 15632078
    9. Prss16 is involved in the positive selection of some CD4(+) T lymphocytes and likely constitutes the first serine protease to play a function in the intrathymic presentation of self-peptides bound to MHC class II complexes. PMID: 19283781

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  • 亚细胞定位：
    Cytoplasmic vesicle. Note=Vesicular, either lysosomal or endosomal.
  • 蛋白家族：
    Peptidase S28 family
  • 组织特异性：
    Expressed predominantly in cortical thymic epithelial cells, with highest expression around vessels and the thymic capsule.
  • 数据库链接：

    KEGG: mmu:54373

    STRING: 10090.ENSMUSP00000006341

    UniGene: Mm.32043