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  4. Recombinant Mouse Tripartite motif-containing protein 16 (Trim16)

Recombinant Mouse Tripartite motif-containing protein 16 (Trim16)

  • 中文名称：
    小鼠Trim16重组蛋白
  • 货号：
    CSB-YP860006MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Trim16重组蛋白
  • 货号：
    CSB-EP860006MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Trim16重组蛋白
  • 货号：
    CSB-EP860006MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Trim16重组蛋白
  • 货号：
    CSB-BP860006MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Trim16重组蛋白
  • 货号：
    CSB-MP860006MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trim16
  • Uniprot No.：
  • 别名：
    Trim16; Ebbp; Tripartite motif-containing protein 16; EC 2.3.2.27; E3 ubiquitin-protein ligase TRIM16; Estrogen-responsive B box protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-556
  • 氨基酸序列
    MAELDLIAPG PLTGVTAHPL APLGPDPVSA IPVEKEDADP LSKSGEETQE QGHDPAELGA PGEEDQILCD FCLGASRVRA VKSCLTCMVN YCEEHLRPHQ ENSKLHSHQL TEPAKDQDLR TCPAHHSPLV SFCHTHQQCI CQECGEGEHR GDSTVSLDAA RRNKEVDLRC MQLDLEQKLK LNENAIARLQ ANHKSVLVSV SEVKVVAEEK FGELLAAVRK AQADVMVFLE EKEQAALNQV NSIKTHLEHR SLEMEKSKQE LERLAAISNT VLFLEEYCKL KKTEDTASPS IYIGLKDKLS GIRKVITDST LNLIQLLESY KEKLQEFSRE EEYDIRTQVS AIVQRKYRTS KPEPRTRDEF LQYACDITFD PDTAHRYLRL QEDNRKVTNT TPWEHPYPDL PSRFLHWRQV LSQQSLYLHR YYFEVELSGG GTYVGLTCKG IDRKGEERNS CISGNSFSWS IHWNGKEFTA WHSDTETPLK VSPFRRLGIY VNFPGGILSF YGVEYDAMTL IHKFDCKFSE PVYAAFWLSK KENAIRIVDL GEEPEKPAGS SVEAAP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.
  • 基因功能参考文献：
    1. we demonstrate that genetic variation in Trim16 leads to its strain-dependent expression, which alters susceptibility to bleomycin-induced pulmonary fibrosis in mice. PMID: 23341783
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Widely expressed. Expressed in basal keratinocytes.
  • 数据库链接：

    KEGG: mmu:94092

    STRING: 10090.ENSMUSP00000055542

    UniGene: Mm.117087