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  4. Recombinant Mouse Tripartite motif-containing protein 54 (Trim54)

Recombinant Mouse Tripartite motif-containing protein 54 (Trim54)

  • 中文名称：
    小鼠Trim54重组蛋白
  • 货号：
    CSB-YP887662MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Trim54重组蛋白
  • 货号：
    CSB-EP887662MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Trim54重组蛋白
  • 货号：
    CSB-BP887662MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Trim54重组蛋白
  • 货号：
    CSB-MP887662MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trim54
  • Uniprot No.：
  • 别名：
    Trim54; Murf; Rnf30; Tripartite motif-containing protein 54; Muscle-specific RING finger protein; MuRF; Muscle-specific RING finger protein 3; MuRF-3; MuRF3; RING finger protein 30
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-366
  • 氨基酸序列
    MNFTVGFKPL LGDAHNMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC ANDVFQASNP LWQSRGSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL VENIIDIYKQ ESSRPLHAKA EQHLMCEEHE DEKINIYCLS CEVPTCSLCK VFGAHKDCEV APLPTIYKRQ KSELSDGIAM LVAGNDRVQA VITQMEEVCQ TIEDNSRRQK QLLNQRFETL CAVLEERKGE LLQALAREQE EKLQRVRGLI RQYGDHLEGS SKLVESAIQS MEEPQMALYL QQAKELINKV GAMSKVELAG RPEPGYESME QFSVSVEHVA EMLRTIDFQP GAAGDEEDDD MALDGEEGNA GLEEERLDVP EGSGLH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May bind and stabilize microtubules during myotubes formation.
  • 基因功能参考文献：
    1. findings suggest that MuRF3 helps stabilize cardiac PPARalpha and PPARgamma1 in vivo to support resistance to the development of diabetic cardiomyopathy. MuRF3 also plays an unexpected role in regulating fat storage despite being found only in striated muscle. PMID: 26215257
    2. Knockdown of both MURF2 and MURF3 severely disrupts the formation of ordered Z- and M-bands, likely by perturbed tubulin dynamics PMID: 21185285
    3. MuRF3 has an essential role in maintaining cardiac integrity and function after acute myocardial infarction and turnover of FHL2 and gamma-filamin contributes to this cardioprotective function of MuRF3 PMID: 17360532
    4. muscle RING finger 1 and muscle RING finger 3 as key E3 ubiquitin ligases for the ubiquitin proteasome system-dependent turnover of sarcomeric proteins and reveal a potential basis for myosin storage myopathies PMID: 17786241
  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles.
  • 组织特异性：
    Selectively expressed in heart and skeletal muscle (at protein level). Also detected in lung and brain at much lower level.
  • 数据库链接：

    KEGG: mmu:58522

    STRING: 10090.ENSMUSP00000013771

    UniGene: Mm.143796