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  4. Recombinant Mouse Tudor and KH domain-containing protein (Tdrkh)

Recombinant Mouse Tudor and KH domain-containing protein (Tdrkh)

  • 中文名称：
    小鼠Tdrkh重组蛋白
  • 货号：
    CSB-YP802232MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tdrkh重组蛋白
  • 货号：
    CSB-EP802232MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tdrkh重组蛋白
  • 货号：
    CSB-EP802232MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tdrkh重组蛋白
  • 货号：
    CSB-BP802232MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tdrkh重组蛋白
  • 货号：
    CSB-MP802232MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tdrkh
  • Uniprot No.：
  • 别名：
    Tdrkh; Tdrd2; Tudor and KH domain-containing protein; Tudor domain-containing protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-560
  • 氨基酸序列
    MSTERTSWTN LSTIQKIALG LGIPASATVA YILYRRYRES REERLTFVGE DDIEIEMRVP QEAVKLIIGR QGANIKQLRK QTGARIDVDT EDVGDERVLL ISGFPVQVCK AKAAIHQILT ENTPVFEQLS VPQRSVGRII GRGGETIRSI CKASGAKITC DKESEGTLLL SRLIKISGTQ KEVAAAKHLI LEKVSEDEEL RKRIAHSAET RVPRKQPISV RREEVTEPGG AGEAALWKNT NSSMGPATPL EVPLRKGGGD MVVVGPKEGS WEKPNDDSFQ NSGAQSSPET SMFEIPSPDF SFHADEYLEV YVSASEHPNH FWIQIIGSRS LQLDKLVSEM TQHYENSLPE DLTVHVGDIV AAPLSTNGSW YRARVLGTLE NGNLDLYFVD FGDNGDCALK DLRALRSDFL SLPFQAIECS LARIAPTGEE WEEEALDEFD RLTHCADWKP LVAKISSYVQ TGISTWPKIY LYDTSDEKKL DIGLELVRKG YAVELPEDME ENRTVPNMLK DMATETDDSL ASILTETKKS PEEMPHTLSC LSLSEAASMS GDDNLEDDLF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.
  • 基因功能参考文献：
    1. Unlike most other Tudor domains TDRD2 preferentially recognizes an unmethylated arginine-rich sequence from PIWIL1. PMID: 29118143
    2. Loss of Tdrkh is associated with impaired spermatogenesis. PMID: 23714778
  • 亚细胞定位：
    Cytoplasm. Mitochondrion. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Colocalizes with pi- and piP-bodies, a subset of the nuage which contains secondary piRNAs. Associated with mitochondria in the germline.
  • 蛋白家族：
    Tdrkh family
  • 组织特异性：
    Highly expressed in testis, present at lower level in brain. Weakly or not expressed in other tissues (at protein level).
  • 数据库链接：

    KEGG: mmu:72634

    STRING: 10090.ENSMUSP00000041002

    UniGene: Mm.331198