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  4. Recombinant Mouse Type-1 angiotensin II receptor-associated protein (Agtrap), partial

Recombinant Mouse Type-1 angiotensin II receptor-associated protein (Agtrap), partial

  • 中文名称：
    Recombinant Mouse Type-1 angiotensin II receptor-associated protein(Agtrap),partial,Yeast
  • 货号：
    CSB-YP893006MO1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Type-1 angiotensin II receptor-associated protein(Agtrap),partial,Yeast
  • 货号：
    CSB-EP893006MO1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Type-1 angiotensin II receptor-associated protein(Agtrap),partial,Yeast
  • 货号：
    CSB-EP893006MO1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Type-1 angiotensin II receptor-associated protein(Agtrap),partial,Yeast
  • 货号：
    CSB-BP893006MO1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Type-1 angiotensin II receptor-associated protein(Agtrap),partial,Yeast
  • 货号：
    CSB-MP893006MO1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Agtrap
  • Uniprot No.：
  • 别名：
    Agtrap; Atrap; Type-1 angiotensin II receptor-associated protein; AT1 receptor-associated protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in angiotensin II-stimulated transcriptional activity. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway.
  • 基因功能参考文献：
    1. high glucose-induced podocytes damage by activating miR-370 signaling targeted to inhibit the expression of AGTRAP. PMID: 30095204
    2. verexpression of ATRAP induced adiponectin expression both in adipose tissue and primary adipocyte. Our data revealed that adipose ATRAP plays an important role in preventing metabolic disorders and adiponectin possibly mediates the effects of adipose ATRAP. PMID: 28539232
    3. ATRAP plays an important role in inhibiting kidney aging, possibly through sirtuin1-mediated mechanism independent of blocking AT1R signaling, and further protecting normal life span. PMID: 28751545
    4. Results presented in this study suggested that the enhancement in adipose ATRAP plays a protective role against the development of diet-induced visceral obesity and insulin resistance through improvement of adipose inflammation and function via the suppression of overactivation of adipose AT1R signaling. PMID: 28264860
    5. Renal ATRAP downregulation is involved in the onset and progression of blood pressure elevation caused by renal mass reduction, and implicates ATRAP as a therapeutic target for hypertension in chronic kidney disease. PMID: 28081856
    6. These results implied that AngII could effectively induce EpiCs to differentiate into vascular smooth muscle-like cells through the AT1 receptor. PMID: 27983984
    7. ATRAP expression in brown adipose tissue does not influence the pathogenesis of dietary obesity or metabolic disorders. PMID: 28335584
    8. Identify Atrap as a novel regulatory protein of the cardiac Ca(2+)-ATPase SERCA2a. Suggest that Atrap enhances the activity of SERCA2a and, consequently, facilitates ventricular relaxation. PMID: 27015675
    9. These results suggest that increased formation of AT1R-P2Y6R heterodimers with age may increase the likelihood of hypertension induced by Ang II. PMID: 26787451
    10. although erythropoiesis and blood pressure are negatively controlled through the AT1 receptor inhibition in vivo, the pathways involved are complex and distinct PMID: 26107632
    11. Distal tubule-dominant enhancement of ATRAP inhibits pathological renal sodium reabsorption and blood pressure elevation in response to high salt loading. PMID: 25792129
    12. AT1R knockout mice were less vulnerable to controlled cortical impact-induced injury. PMID: 26115674
    13. The inhibition of degradation of angiotensin II type 1 receptor-associated protein (ATRAP) and inactivation of AT1R-mediated p38 MAPK and STAT3 signaling pathways, are involved cardiac hypertrophy. PMID: 25526681
    14. Activation of aortic vascular ATRAP partially inhibits the Nox4/p22(phox)-ROS-p38MAPK/JNK pathway and pathological aortic hypertrophy provoked by Ang II-mediated hypertension. PMID: 24189624
    15. ATRAP, a directly interacting and functionally inhibiting molecule of AT1R, plays a protective role against the development of systemic insulin resistance via regulatory effects on adipose tissue function. PMID: 23902639
    16. AGTRAP expression is regulated by USF1 and USF2 PMID: 23653383
    17. renal tubule-dominant ATRAP activation provokes no evident effects on blood pressure at baseline but exerts an inhibitory effect on the pathological elevation of blood pressure in response to angiotensin II stimulation PMID: 23529167
    18. These data imply an involvement of AT1R in fetal development and of AT2R in adult function. PMID: 22526820
    19. angiotensin-receptor-associated-protein and TRPV2 channel have roles in Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium PMID: 23185387
    20. These results suggest that the stimulation of mouse iPS cells with AT(1)R may enhance LIF-induced DNA synthesis, by augmenting the generation of superoxide and activating JAK/STAT3, and that AT(1)R stimulation may enhance Col IV-induced differentiation into mesodermal progenitor cells via p38 MAPK activation. PMID: 22405822
    21. Angiotensin II modulates Vegf-induced angiogenesis through opposing effects of angiotensin II receptor type 1 and type 2. PMID: 22374305
    22. Ang II up-regulated EMMPRIN expression in atherosclerotic plaque via AT1R. PMID: 22020146
    23. Angiotensin II causes endothelial dysfunction in diabetes via the Akt/eNOS pathway, and an increase in plasma Angiotensin II increases the vascular GRK2 level. PMID: 21571071
    24. Runx3 plays a role in ATRAP gene expression in renal distal tubular cells both in vitro and in vivo. PMID: 21586669
    25. Findings suggest that adipocyte-derived factors regulate VSMC function through specific MAPKs linked to MR, GR, and AT(1)R, a posttranslational phenomenon. PMID: 21788604
    26. The AT1R receptor interacts functionally with the type 1 cannabinoid receptor (CB1R), resulting in the potentiation of AT1R signalling and the coupling of AT1R to multiple G proteins. PMID: 21540834
    27. These results imply that the angiotensin II receptor (type 1) contributes to heart failure due to calsequestrin overexpression, as its blockade improved survival PMID: 20697885
    28. expression directly regulated by the cannabinoid receptor CB(1) PMID: 20361197
    29. These findings collectively suggest that mechanical stress-evoked but AngII-independent activation of AT(1) receptor induces cardiac hypertrophy through calcineurin pathway. PMID: 20580688
    30. through AT1R, angiotensin II promotes postnatal expansion of postglomerular capillaries and organization of vasa recta bundles, which are necessary for development of normal renal blood flow PMID: 20056745
    31. Atrap seems to modulate volume status by acting as a negative regulator of AT1 receptors in the renal tubules PMID: 20093357
    32. ATRAP-mediated inactivation of the calcineurin/NFAT pathway could be at least partly involved in prevention of vascular smooth muscle cells senescence. PMID: 19769983
    33. Chronic activation of AT1R induces unregulated expression of the Stat3 gene, leading to nuclear accumulation of U-STAT3, which significantly correlated with progression of cardiac hypertrophy. PMID: 19696070
    34. interact specifically with the carboxyl-terminal cytoplasmic region of the angiotensin II type 1 (AT(1)) receptor to regulate different aspects of AT(1) receptor physiology PMID: 11733189
    35. The inhibitory effect of angiotensin II (Ang-II) on macrophage cholesterol efflux is mediated by the Ang-II type 1 (AT1) receptor, as shown by the addition of the AT1 receptor antagonist losartan on peritoneal macrophages prelabeled with [3H] cholesterol. PMID: 11820795
    36. in the expressing AT1R, the EGF-induced MAPK pathway was enhanced in the presence of Ang II in a synergistic fashion PMID: 11910305
    37. oxidative stress in macrophages induces AT(1)-receptor expression and can accelerate macrophage foam cell formation and early atherogenesis PMID: 11984744
    38. Angiotensin II type 1a receptor mediates doxorubicin-induced cardiomyopathy. PMID: 12358147
    39. Data show that the angiotensin II type 1 receptor on macrophages functions in vivo to attenuate fibrogenetic processes and preserve renal parenchymal architecture. PMID: 12488436
    40. direct and independent role for ANG II acting via AT1 receptors on ureteric bud cell branching in vitro PMID: 12657564
    41. Caveolin-1 and caveolin-3 act as a molecular chaperone rather than a plasma membrane scaffold for AT1-R through the exocytic pathway. PMID: 12692121
    42. ATRAP interaction with AT1 receptor reveals decrease in the generation of inositol lipids,in the angiotensin II-stimulated transcriptional activity and a decrease in cell proliferation. PMID: 12960423
    43. glomerular podocytes express a high-affinity binding site for Ang II with pharmacologic characteristics of both AT1 and AT2 receptors PMID: 14647035
    44. Upregulation of vascular AT1 receptor expression in vitro & in vivo is involved in IL-6-induced propagation of oxidative stress & endothelial dysfunction. Interaction of IL-6 with the renin-angiotensin system may link inflammation & atherosclerosis. PMID: 14699015
    45. aortic banding induces upregulation of the AT2 receptor through increased circulating Ang II via the AT1 receptor, thereby activating a vasodilatory pathway in vessels through the AT2 receptor via the kinin/cGMP system. PMID: 15123575
    46. Both AT1 receptor subtypes are present in mouse hypothalamus, brainstem and anterior pituitary, and that there is differential regulation of expression in response to changes in dietary salt PMID: 15246823
    47. Genetic disruption of the AT1A receptor leads to inhibition of vascular oxidative stress, endothelial dysfunction, & atherosclerotic lesion formation in ApoE-/- mice, indicating a fundamental role of AT1 receptor activation in atherogenesis. PMID: 15277329
    48. Ptn has the potential to critically regulate the downstream activities of angiotensin II, through the regulation of its synthesis by ACE and its receptor mediated functions through regulation of both the AT1 and AT2 receptors PMID: 15485659
    49. The results indicate an Ang II-induced nitric oxide release in afferent arterioles of mice, which is mediated by AT1 receptors. PMID: 15496166
    50. ATRAP significantly promotes downregulation of the AT1R and attenuates certain Ang II-mediated hypertrophic responses in cardiomyocytes. PMID: 15757644

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
  • 组织特异性：
    Ubiquitous but more abundant in kidney, testis and heart.
  • 数据库链接：

    KEGG: mmu:11610

    STRING: 10090.ENSMUSP00000030865

    UniGene: Mm.46247