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  4. Recombinant Mouse Uncharacterized protein C11orf74 homolog (Nwc)

Recombinant Mouse Uncharacterized protein C11orf74 homolog (Nwc)

  • 中文名称：
    小鼠Nwc重组蛋白
  • 货号：
    CSB-YP875113MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Nwc重组蛋白
  • 货号：
    CSB-EP875113MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Nwc重组蛋白
  • 货号：
    CSB-EP875113MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Nwc重组蛋白
  • 货号：
    CSB-BP875113MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Nwc重组蛋白
  • 货号：
    CSB-MP875113MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nwc
  • Uniprot No.：
  • 别名：
    NwcProtein C11orf74 homolog; Protein NWC
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-244
  • 氨基酸序列
    MLAQIPRPEI MDEDQLMKEV LDKFVNCHEQ TYEEFLSTFT HLSKEDNVAK WGAHGTDSSE NIFSTVKWNH KTESNGRHFR NTSIFLHTSS EHSEEDQIVI DEGHKVGSSF QGDMTRAGKV KVDNFLDLED VDMEEESKPQ MNKDCLLLPG EVEQDISTSV PSYDPSVDLP LTSEVRPKPA VGRTQKQTEE ILGDEVQPFF LDEEFDYDNV TLTPKFTAGE IATIQELSKQ KRVGSGTNVC ELHD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex.
  • 基因功能参考文献：
    1. functional inactivation of NWC does not cause any gross developmental, physiological or reproductive abnormalities, and that under physiological conditions NWC may be involved in assembling and functioning of cilia PMID: 26703212
    2. Ikaros, a lymphocyte-specific transcription factor, acts as a repressor of NWC promoter--thus identifying a new Ikaros target--but is insufficient for inducing methylation which depends on antisense transcription driven by RAG-2 promoter PMID: 25198102
    3. Bidirectional activity of the NWC promoter is responsible for RAG-2 transcription in non-lymphoid cells PMID: 22984564
    4. Careful analysis of the Rag2 intergenic region uncovered a second evolutionarily conserved Nwc promoter region from which a previously unknown Nwc transcript can be generated in nonlymphocytes of Nwctmpro1 and normal mice. PMID: 21243488
    5. NWC is regulated in lymphocytes by RAG1 promoter, in all other cells by RAG2 intragenic promoter PMID: 15971274
    6. These results indicate that accessibility of NWC promoter and RAG promoters to trans-acting factors is regulated by different epigenetic mechanisms. PMID: 18166226

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  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    KEGG: mmu:68170

    STRING: 10090.ENSMUSP00000087999

    UniGene: Mm.31263