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  4. Recombinant Mouse Zinc finger protein SNAI3 (Snai3)

Recombinant Mouse Zinc finger protein SNAI3 (Snai3)

  • 中文名称：
    小鼠Snai3重组蛋白
  • 货号：
    CSB-YP879451MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Snai3重组蛋白
  • 货号：
    CSB-EP879451MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Snai3重组蛋白
  • 货号：
    CSB-EP879451MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Snai3重组蛋白
  • 货号：
    CSB-BP879451MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Snai3重组蛋白
  • 货号：
    CSB-MP879451MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Snai3
  • Uniprot No.：
  • 别名：
    Snai3; Smuc; Zfp293; Zinc finger protein SNAI3; Protein snail homolog 3; Snail-related gene from muscle cells; Zinc finger protein 293
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-287
  • 氨基酸序列
    MPRSFLVKTH SSHRVPNYGK LETLREANGS CSACKELAGS RHLPDEEAPC NPSDPLQPWD STSAVACISL PLLPNHRETL GVSGPEPQET SWVGPRAAQA PSVTLKDSFT LPPLLVLPTR WPPILGPDGA LNEHLRAEGT SRVPGSFECI HCHRPYHTLA GLARHQQLHC HLPTGRAFTC RYCDKEYASL GALKMHIRTH TLPCICKVCG KAFSRPWLLQ GHIRTHTGEK PYTCSHCSRA FADRSNLRAH LQTHVGTKKY RCAVCPKAFS RMSLLARHEE AGCCPGP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3'.
  • 基因功能参考文献：
    1. Data suggest that expression of SNAI3 in ovary is reduced during ovulation, after which it increases gradually during luteinization. During early embryo cleavage, SNAI3 is localized to nucleus, except nucleolus at germinal vesicle and one-cell stages. PMID: 29445069
    2. using global gene expression analysis of partially reprogrammed cells, we identified SNAI3 as a novel invasion-related marker in human melanoma. SNAI3 expression correlates with tumor thickness in primary melanomas and thus, may be of prognostic value PMID: 26753613
    3. Snai3 gene function is not essential for embryogenesis in mice. PMID: 23762348
    4. overexpression of Snai3 does alter bone marrow cell development PMID: 22531927
    5. Snail genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication PMID: 14655014
    6. Expression of Snai3 was studied during mouse development. PMID: 15870897
    7. Snail is present in activated mesenchymal cells indicating its relevance in the communication between tumor and stroma and suggest that it can promote the conversion of carcinoma cells to stromal cells. PMID: 16568079
    8. These data implicate Smuc as blocking Pactolus transcription in cells expressing PU.1 (and CD18) but not Pactolus. PMID: 16735694

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Snail C2H2-type zinc-finger protein family
  • 组织特异性：
    Highly expressed in skeletal muscle and thymus. Lower expression in heart, lung and spleen.
  • 数据库链接：

    KEGG: mmu:30927

    STRING: 10090.ENSMUSP00000006762

    UniGene: Mm.103673