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  4. Recombinant Mycobacterium bovis Disfunctional anti-sigma-K factor rskA (rskA), partial

Recombinant Mycobacterium bovis Disfunctional anti-sigma-K factor rskA (rskA), partial

  • 中文名称：
    牛型结核菌rskA重组蛋白
  • 货号：
    CSB-YP374872MOJ
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    牛型结核菌rskA重组蛋白
  • 货号：
    CSB-EP374872MOJ
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    牛型结核菌rskA重组蛋白
  • 货号：
    CSB-EP374872MOJ-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    牛型结核菌rskA重组蛋白
  • 货号：
    CSB-BP374872MOJ
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    牛型结核菌rskA重组蛋白
  • 货号：
    CSB-MP374872MOJ
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    rskA
  • Uniprot No.：
  • 别名：
    rskA; BCG_0483c; Dysfunctional anti-sigma-K factor RskA; Regulator of SigK; Sigma-K anti-sigma factor RskA
  • 种属：
    Mycobacterium bovis (strain BCG / Pasteur 1173P2)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). However, in M.bovis this protein is probably dysfunctional, due to at least 1 of the 2 naturally occurring polymorphisms in its gene, when compared to M.tuberculosis. This leads to an increased expression of SigK-regulated genes, such as mpb70 and mpb83. RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor.
  • 亚细胞定位：
    Cell membrane; Single-pass membrane protein.
  • 蛋白家族：
    Anti-sigma-K factor family
  • 数据库链接：

    KEGG: mbb:BCG_0483c