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  4. Recombinant Pig E3 SUMO-protein ligase EGR2 (EGR2)

Recombinant Pig E3 SUMO-protein ligase EGR2 (EGR2)

  • 中文名称：
    斯克罗法EGR2重组蛋白
  • 货号：
    CSB-YP007485PI
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    斯克罗法EGR2重组蛋白
  • 货号：
    CSB-EP007485PI
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    斯克罗法EGR2重组蛋白
  • 货号：
    CSB-EP007485PI-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    斯克罗法EGR2重组蛋白
  • 货号：
    CSB-BP007485PI
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    斯克罗法EGR2重组蛋白
  • 货号：
    CSB-MP007485PI
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    EGR2E3 SUMO-protein ligase EGR2; EC 2.3.2.-; E3 SUMO-protein transferase ERG2; Early growth response protein 2; EGR-2
  • 种属：
    Sus scrofa (Pig)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-471
  • 氨基酸序列
    MMTAKAVDKI PVTLSGFVHQ LSDNIYPVED LAATSVTIFP NAELGSPFDQ MNGVAGDGMI NIDMTGEKRS LDLPYPSSFA PVSAPRNQTF TYMGKFSIDP QYPGASCYPE GIINIVSAGI LQGVTSPAST TASSNVTSAS PNPLATGPLG VCTMSQTQPD LDHLYSPPPP PPYSGCAGDL YQDPSAFLSA ATTSTSSSLA YPPPPSYPSP KPATDPGLFP MIPDYPGFFP SQCQRDLHGT AGPDRKPFPC PLDSLRVPPP LTPLSTIRNF TLGGPSAGTT GPGASGGSEG PRLPGSSAAA AAAAYNPHHL PLRPILRPRK YPNRPSKTPV HERPYPCPAE GCDRRFSRSD ELTRHIRIHT GHKPFQCRIC MRNFSRSDHL TTHIRTHTGE KPFACDYCGR KFARSDERKR HTKIHLRQKE RKSSAPSSSV PAASTASCTG GAQPGGPLCS SNSSTIGGGS LGPCSSRTRT P
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific DNA-binding transcription factor. Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin. Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation. Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2. Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres. Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain. Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells. Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons. May play a role in adipogenesis, possibly by regulating the expression of CEBPB.; E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity.
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    EGR C2H2-type zinc-finger protein family
  • 数据库链接：

    KEGG: ssc:100038004

    STRING: 9823.ENSSSCP00000010899

    UniGene: Ssc.51140