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Recombinant Porphyromonas gingivalis Gingipain R2 (rgpB), partial

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  • 中文名称:
    Recombinant Porphyromonas gingivalis Gingipain R2(rgpB),partial
  • 货号:
    CSB-EP310587EYA
  • 规格:
    ¥2328
  • 图片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP310587EYA could indicate that this peptide derived from E.coli-expressed Porphyromonas gingivalis (strain ATCC BAA-308 / W83) rgpB.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP310587EYA could indicate that this peptide derived from E.coli-expressed Porphyromonas gingivalis (strain ATCC BAA-308 / W83) rgpB.
  • 其他:

产品详情

  • 纯度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    rgpB
  • Uniprot No.:
  • 别名:
    rgpB; prtRII; rgp2; PG_0506Gingipain R2; EC 3.4.22.37; Arg-gingipain; Gingipain 2; RGP-2
  • 种属:
    Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
  • 蛋白长度:
    Partial
  • 来源:
    E.coli
  • 分子量:
    43.3kDa
  • 表达区域:
    230-473aa
  • 氨基酸序列
    YTPVEEKENGRMIVIVPKKYEEDIEDFVDWKNQRGLRTEVKVAEDIASPVTANAIQQFVKQEYEKEGNDLTYVLLVGDHKDIPAKITPGIKSDQVYGQIVGNDHYNEVFIGRFSCESKEDLKTQIDRTIHYERNITTEDKWLGQALCIASAEGGPSADNGESDIQHENIIANLLTQYGYTKIIKCYDPGVTPKNIIDAFNGGISLANYTGHGSETAWGTSHFGTTHVKQLTNSNQLPFIFDVAC
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签:
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液:
    Tris-based buffer,50% glycerol
  • 储存条件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期:
    3-7 business days
  • 注意事项:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述:

    Porphyromonas gingivalis Gingipain R2/rgpB (CSB-EP310587EYA) with an N-terminal 6xHis-SUMO-tag is a partial-length recombinant protein generated in E.coli. The expressed region encodes the AA Tyr230-Cys473 of Porphyromonas gingivalis. This recombinant rgpB protein was evaluated by the LC-MS/MS analysis. The purity of this protein is up to 90% through SDS-PAGE analysis. This protein may be used to produce specific antibodies or in the studies of microbiology.

    Arginine-specific gingipain 2 (rgpB) is an arginine-specific extra-cellular protease expressed on the surface of the oral pathogen Porphyromonas gingivalis outer membrane. It is one of the major viral virulence factors. Endogenous peptidylarginine deiminase enzyme (P.PAD), a virulence factor capable of citrullinating human and bacterial proteins, including auto-citrullination, interacts with rgpB. RgpB is essential for P. gingivalis to citrullinate peptides. Only after degradation by rgpB can P.PAD convert peptidylarginine into peptidylcitrulline.

  • Datasheet & COA:
    Please contact us to get it.

产品评价

靶点详情

  • 功能:
    Thiol protease. Acts synergistically with RgpA to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms.
  • 亚细胞定位:
    Secreted.
  • 蛋白家族:
    Peptidase C25 family
  • 数据库链接:

    KEGG: pgi:PG_0506

    STRING: 242619.PG0506