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  4. Recombinant Rat Ankyrin repeat domain-containing protein 1 (Ankrd1)

Recombinant Rat Ankyrin repeat domain-containing protein 1 (Ankrd1)

  • 中文名称：
    Recombinant Rat Ankyrin repeat domain-containing protein 1(Ankrd1),Yeast
  • 货号：
    CSB-YP848137RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Ankyrin repeat domain-containing protein 1(Ankrd1),Yeast
  • 货号：
    CSB-EP848137RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Ankyrin repeat domain-containing protein 1(Ankrd1),Yeast
  • 货号：
    CSB-EP848137RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Ankyrin repeat domain-containing protein 1(Ankrd1),Yeast
  • 货号：
    CSB-BP848137RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Ankyrin repeat domain-containing protein 1(Ankrd1),Yeast
  • 货号：
    CSB-MP848137RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ankrd1
  • Uniprot No.：
  • 别名：
    Ankrd1; CarpAnkyrin repeat domain-containing protein 1; Cardiac adriamycin-responsive protein; Cardiac ankyrin repeat protein
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-319
  • 氨基酸序列
    MMVFRVEELV TGKKNSNGSS GEFLPGEFRN GEYEAAVALE KQEDLKTLPA NSVNLGEEQR KSEKVREAEL KKKKLEQRSK LENLEDLEII VQLKKRKKYK KTKVPVVKEP EPEIITEPVD VPRFLKAALE NKLPVVEKFL SDKNSPDVCD EYKRTALHRA CLEGHLAIVE KLMEAGAQIE FRDMLESTAI HWACRGGNLD VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA CEADLNAKDR EGDTPLHDAV RLNRYKMIRL LMTFGADLNV KNCAGKTPMD LVLHWQNGTK AIFDSLKENA YKNSRIATF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.
  • 基因功能参考文献：
    1. Overexpression of Ankrd1 exacerbates pathological cardiac remodeling through the enhancement of cytosolic translocation of CARP and up-regulation of calcineurin. PMID: 25089522
    2. Ankrd1 binds to and directly regulates the transcriptional activity of the human androgen receptor in cultured rat myoblasts, whereas Ankrd2 does not. PMID: 23811403
    3. the 26S proteasome is the dominant regulator of Ankrd1/CARP degradation, and that Ankrd1/CARP half-life is significantly longer in cardiomyocytes (h) than endothelial cells (min). PMID: 22892129
    4. These data demonstrate co-dependent roles for GATA4 and CARP in regulating sarcomere gene expression and maintaining sarcomeric organization in cardiomyocytes in culture. PMID: 22532871
    5. Data show that CARP specific expressed in mouse heart and mainly localized in the nucleus in rat cardiac primary cells. PMID: 19500504
    6. GADD153 overexpression and the concomitant down-regulation of CARP might have a causative role in the apoptotic cell injury of hypoxic H9c2 cells PMID: 15826945
    7. Results suggest that GADD153 over-expression and the resulting downregulation of cardiac ankyrin repeat protein may have causative roles in apoptotic cell death during cardiac ischemia-reperfusion injury. PMID: 19299913

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in heart, cardiac muscle.
  • 数据库链接：

    KEGG: rno:27064

    STRING: 10116.ENSRNOP00000025258

    UniGene: Rn.3789