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  4. Recombinant Rat Appetite-regulating hormone (Ghrl), partial

Recombinant Rat Appetite-regulating hormone (Ghrl), partial

  • 中文名称：
    大鼠Ghrl重组蛋白
  • 货号：
    CSB-YP889887RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Ghrl重组蛋白
  • 货号：
    CSB-EP889887RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Ghrl重组蛋白
  • 货号：
    CSB-EP889887RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Ghrl重组蛋白
  • 货号：
    CSB-BP889887RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Ghrl重组蛋白
  • 货号：
    CSB-MP889887RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ghrl; Appetite-regulating hormone; Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin-23; Obestatin-13]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 表达区域：
    24-51
  • 氨基酸序列
    GSSFLSP EHQKAQQRKE SKKPPAKLQP R
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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靶点详情

  • 功能：
    Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.; Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
  • 基因功能参考文献：
    1. Obestatin regulates cardiovascular function and promotes cardioprotection through the nitric oxide pathway. PMID: 28744974
    2. Targeted inhibition of ghrelin gene in pancreatic acinar cells of acute pancreatitis can upregulate the expression of the intracellular inflammatory factors and alleviate the intracellular calcium overload. PMID: 28984792
    3. Study concludes that the ghrelin receptors of the lumbosacral defecation centers have a physiological role in the control of defecation, but that their role is not dependent on ghrelin. PMID: 28801520
    4. Study shows that ghrelin appears to act as a modulating factor for binge-like eating behaviour by shifting food preference towards a more nutritious choice (from high fat diet to chow), with these effects being somewhat divergent from fasting. PMID: 28219000
    5. results reveal that ghrelin can regulate negative emotionality in unstressed animals without altering appetite. PMID: 28010876
    6. Findings provide evidence that ghrelin and glucagon-like peptide-1 signaling interact in the hypothalamic control of metabolic function. PMID: 27454242
    7. ghrelin may provide neuroprotective effect in COH retinas through activating ghrelin/GHSR-1a system, which was mediated by inhibiting retinal autophagy, ganglion cell apoptosis, and Muller cell gliosis. PMID: 29222553
    8. These results provide new insights into the mechanism by which ghrelin regulates voluntary activity independent of arcuate nucleus neurons. PMID: 27825986
    9. In order to elucidate the possible role of HO-1 in mediating the protective effects of ghrelin, tin protoporphyrin (SnPP) HO-1 blocker was administrated; it significantly attenuated the gastroprotective effect of ghrelin. In conclusion HO-1 activity significantly contributes toward ghrelin-mediated gastroprotection. PMID: 28635609
    10. Expression of ghrelin and ghrelin receptor and glucose stimulated insulin secretion (GSIS) of pancreatic islets. PMID: 28410130
    11. l-Ornithine stimulates growth hormone secretion through the sympathetic nervous and ghrelin systems. PMID: 28513740
    12. These findings have implications for how females may respond to stress throughout life, suggesting the way ghrelin modifies the stress response at the level of the pituitary may be less efficient in the neonatally overfed. PMID: 28282447
    13. Data suggest that changes in obestatin, GPR39, and ghrelin may contribute to metabolic abnormalities in T1DM, T2DM, and obesity. PMID: 27106635
    14. Up-regulation of miR-21 by ghrelin ameliorates ischemia/reperfusion-induced acute kidney injury by inhibiting inflammation and cell apoptosis. PMID: 27152763
    15. First demonstration that the stomach-produced hormone ghrelin increases impulsivity and also indicates that ghrelin can change two major components of impulsivity-motor and choice impulsivity. PMID: 26424164
    16. Findings show that obestatin is expressed in adult rat hippocampal progenitor cells promoting cell proliferation and preventing apoptosis. PMID: 26586206
    17. Ghrelin positively regulates GI motility by exciting both central and enteric neurons, including those of paraventricular nucleus by activating growth hormone secretagogue receptor & neuropeptide Y pathways & muscarinic acetylcholine receptors PMID: 26431788
    18. Results from this study indicate that exogenous ghrelin induces expression and activity of cardiac iNOS via Akt phosphorylation followed by NFkappaB activation in HF rats. PMID: 26600052
    19. These results suggest that administration of ghrelin ameliorates impaired angiogenesis in diabetic MI rats. And these beneficial effects derive from regulating GHSR1a-mediated AMPK/eNOS signal pathway PMID: 26364514
    20. The expression of hypothalamic ghrelin was suppressed at puberty onset. PMID: 24668712
    21. Central acylated ghrelin improves memory function and hippocampal AMPK activation and partly reverses the impairment of energy and glucose metabolism in rats infused with beta-amyloid. PMID: 26188171
    22. Because ghrelin is related to food anticipatory activity, it is plausible that ghrelin participates in the circadian rhythm of daily activity including eating behavior. PMID: 26122892
    23. Administration of either obestatin or ghrelin exerts similar protective effects against I/R-induced ileal and pulmonary injury, thus warranting further investigation for their possible use against ischemic intestinal injury. PMID: 26032330
    24. The results of the present study suggest that ghrelin secretion from isolated islets is not glucose-dependent. PMID: 26612921
    25. may act primarily via a central pathway within the brain to suppress sympathetic nerve activity after myocardial infarction PMID: 26121343
    26. Gastric ghrelin levels increased in two- and three-month diabetic rats compared to the control rats. PMID: 26467127
    27. The ghrelin system may play an important role regulating cardiac remodeling after MI and present as a potential significant target for pharmacological modulation and treating cardiac remodeling. PMID: 25058156
    28. Results suggest that ghrelin mediates a novel branch of the stress response and highlight a previously unrecognized role for ghrelin and growth hormone in maladaptive changes following prolonged stress PMID: 24126924
    29. Total serum ghrelin levels were significantly increased in rats with human neuroblastoma transplants and altered for those with hepatoblastoma. PMID: 25111274
    30. The data showed that intraportal infusion of ghrelin exerted an inhibitory effect on GLP-1 secretion through growth hormone secretagogue receptor 1alpha (GHS1alpha receptor). PMID: 25247193
    31. Ghrelin may exert its effects by influencing the functional status of different cell types in the gastric muscle layer to subsequently enhance the contractive effect of cholinergic neurotransmitters and enhance gastric motility. PMID: 25230765
    32. Acute orexigenic and hyperglycemic effects of T3 are associated with ghrelin secretion and activity. PMID: 24357139
    33. these results suggest that ghrelin markedly decreases IBa via the activation of GHS-R1a, which is coupled sequentially to the activities of Go-protein betagamma subunits and the downstream PKA pathway PMID: 25049077
    34. These results indicate the importance of peripheral obestatin in the cholinergic control of intestinal contractility in both neonatal and adult rats. PMID: 25193331
    35. our results demonstrate that protein kinase C delta phosphorylation at Ser/Tyr plays a critical role in the modulation of gastric mucosal inflammatory responses to H. pylori LPS by ghrelin PMID: 24840386
    36. ghrelin enhances the proliferation of murine CD4+ primary T cells and a CD4+ T-cell line PMID: 25447526
    37. Ghrelin expression was detected in the ciliary processes and GHSR-1 expression was detected in the trabecular meshwork and ciliary body. PMID: 24780389
    38. Ghrelin has a role in modulating fMRI BOLD response of homeostatic and hedonic brain centers regulating energy balance in male but not female rats PMID: 24830778
    39. Peripherally circulating ghrelin was found to not mediate alcohol-induced reward. PMID: 24428428
    40. Total ghrelin secretion during the 24-h period increased in the restricted feeding schedule as a result of elevation of the unacylated form PMID: 24617825
    41. Serum levels of ghrelin are significantly positively correlated with Ang II in chronic heart failure (CHF) patients and that ghrelin can inhibit Ang II-induced cardiomyocyte apoptosis by down-regulating AT1R, thereby playing a role in preventing HF. PMID: 24465706
    42. Bilateral ovariectomization leads to histological changes in the uterine tissue and decreased endometrium ghrelin immunoreactivity. PMID: 24979506
    43. It is mainly produced in the stomach and inhibits the neural activity of the gastric branch of the afferent vagus nerve PMID: 24366191
    44. Ghrelin plays an important role in promoting gastric motility. PMID: 24036593
    45. Ghrelin stimulates food intake and weight gain and may also induce mechanisms of cell protection that help to detour or delay systemic inflammatory responses and hypothalamic gliosis due to excess weight gain. PMID: 24848869
    46. Acylated ghrelin leads to earlier network formation and activation in cultured cortical neuronal networks, the latter being a possibly consequence of accelerated synaptogenesis. PMID: 24742241
    47. Ghrelin accelerates the healing of oral ulcers. PMID: 24304579
    48. data identify the VTA to NAc dopaminergic projections, along with D1-like and D2 receptors in the NAc, as essential elements of the ghrelin responsive circuits controlling food reward behavior. PMID: 23770258
    49. Ghrelin administration reduced ventricular arrhythmias concomitant with prevention of the loss of connexin-43 during acute myocardial infarction. PMID: 23494606
    50. After 2-weeks of hypoxia, erythropoietin transcripts and erythropoietin plasma levels were significantly increased in hypoxic animals compared with control animals. PMID: 24524370

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Motilin family
  • 组织特异性：
    Ghrelin is broadly expressed with higher expression in the stomach. Very low levels are detected in the hypothalamus, heart, lung, pancreas, intestine and adipose tissue. Obestatin is most highly expressed in jejunum, and also found in duodenum, stomach,
  • 数据库链接：

    KEGG: rno:59301

    STRING: 10116.ENSRNOP00000014103

    UniGene: Rn.42103