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  4. Recombinant Rat Fibronectin type III domain-containing protein 5 (Fndc5), partial

Recombinant Rat Fibronectin type III domain-containing protein 5 (Fndc5), partial

  • 中文名称：
    大鼠Fndc5重组蛋白
  • 货号：
    CSB-YP810392RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Fndc5重组蛋白
  • 货号：
    CSB-EP810392RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Fndc5重组蛋白
  • 货号：
    CSB-EP810392RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Fndc5重组蛋白
  • 货号：
    CSB-BP810392RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Fndc5重组蛋白
  • 货号：
    CSB-MP810392RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fndc5
  • Uniprot No.：
  • 别名：
    Fndc5Fibronectin type III domain-containing protein 5 [Cleaved into: Irisin]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA.
  • 基因功能参考文献：
    1. The results of the study suggest that irisin values increase in thyroid dysfunction, hypo- and hyperthyroidism, and that when hypothyroidism is corrected by thyroxin administration and hyperthyroidism by PTU injection, plasma irisin values go back to normal. PMID: 29182513
    2. e suggested that levels of circulating irisin are the result of the sum of the irisin produced by different depots of adipose tissue and skeletal muscle. This study shows for the first time that there are differences in FNDC5 expression depending on white adipose tissue depots. PMID: 27432282
    3. The secretion of FNDC5 from myotubes and beta-cells in response to exogenous fatty acids, the effects of recombinant FNDC5 on insulin biosynthesis and glucose-stimulated insulin secretion, and beta-cell apoptosis are reported. PMID: 28724742
    4. results firstly revealed that irisin mitigated oxygen-glucose deprivation-induced neuronal injury in part via inhibiting ROS-NLRP3 inflammatory signaling pathway, suggesting a likely mechanism for irisin-induced therapeutic effect in ischemic stroke. PMID: 28961497
    5. Irisin could affects the nutrition behavior and energy metabolism. PMID: 28242329
    6. Study demonstrated that irisin promotes beta cell proliferation through the ERK and p38 MAPK signaling pathways. Irisin can also inhibit the high-glucose-induced apoptosis of INS-1 cells and improve the function of pancreatic beta cells. Findings suggest that irisin may have applications in the prevention and treatment of type 2 diabetes mellitus because of its protective effect on the secretion of pancreatic beta cells. PMID: 28394923
    7. Swimming exercise increases serum Fndc5 level. PMID: 27177924
    8. the expression of FNDC5 in the stomach of rats and its regulation by body composition, suggesting a potential role of gastric FNDC5 in energy homeostasis. PMID: 26961074
    9. the irisin affects the expression of the UCPs in a central way. PMID: 26926562
    10. Methylprednisolone and carnosine and the combination of the two, significantly increased irisin in plasma and were accompanied by a significant rise in irisin immunoreactivity of brain and spinal cord tissues of the injured rats PMID: 26142757
    11. studies indicate that central and peripheral irisin may differentially regulate cardiovascular activities. PMID: 25820670
    12. the fat-burning protein irisin locally produced in peripheral and central tissues could act as a gatekeeper of metabolic energy regulation in those tissues PMID: 25261800
    13. changes in irisin mRNA and protein levels in rat muscle after acute exercise are limited and depend on training status and the muscle type; irisin serum levels remained stable after acute exercise or endurance training PMID: 24930518
    14. Irisin increases near myocardial connective tissue, with production in skeletal muscle, liver and kidney after myocardial infarction. PMID: 24576483
    15. High supernatant irisin could come from connective tissues around skeletal muscle, especially nerve sheaths located within it. Skeletal muscle is probably not a main irisin source. PMID: 24345335
    16. This immunohistochemical results demonstrate the expression of irisin immunoreactivity in three types of cells: skeletal, cardiac muscle, and Purkinje cells of the cerebellum. PMID: 23470775
    17. Further research is needed to examine whether other adipose tissue-derived factors up-regulate FNDC5 transcription and/or inhibit irisin biosynthesis from FNDC5 PMID: 23498898
    18. In addition to skeletal muscles, white adipose tissue also secretes FNDC5; hence, it may behave as an adipokine as well as a myokine. PMID: 23593248

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein.
  • 数据库链接：

    KEGG: rno:260327

    STRING: 10116.ENSRNOP00000048830

    UniGene: Rn.18757