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  4. Recombinant Rat HCLS1-associated protein X-1 (Hax1)

Recombinant Rat HCLS1-associated protein X-1 (Hax1)

  • 中文名称：
    大鼠Hax1重组蛋白
  • 货号：
    CSB-YP749270RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Hax1重组蛋白
  • 货号：
    CSB-EP749270RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Hax1重组蛋白
  • 货号：
    CSB-EP749270RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Hax1重组蛋白
  • 货号：
    CSB-BP749270RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Hax1重组蛋白
  • 货号：
    CSB-MP749270RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hax1
  • Uniprot No.：
  • 别名：
    Hax1; Hs1bp1HCLS1-associated protein X-1; HS1-associating protein X-1; HAX-1; HS1-binding protein 1; HSP1BP-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-278
  • 氨基酸序列
    SVFDLFRGF FGFPGPRSHR DPFFGGMTRD DDDDEDDEEE EDSGAWGRES YAFDGFHPTE EFGFSFSPRG GMRFHGNFGF DDLVRDFNSI FSEMGAWTLP SHSPELPGPE SETPGVRLRE GQTLRDSMLK YPDSHQPRIF EGVLESHAKP ESSKPAPDWG SQGPFHRLDD TWPVSPHSRA REDKDLDSQV SQEGLGPLLQ PQPKSYFKSI SVTKITKPDG TVEEHRTVVD SEGRRETTVT HQEAHDSSRS DPDPPRSSAL DDPFSILDLL LGRWFRSR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.
  • 基因功能参考文献：
    1. our data indicated that HAX1 might play significant roles in pathological process of neuronal apoptosis and astrocyte proliferation during spinal cord injury PMID: 30309497
    2. Hax1 is significantly downregulated in cardiac cells upon endoplasmic reticulum stress induction. PMID: 27654581
    3. these results suggested that Hax1 may participate in regulating RGC apoptosis via interacting with caspase3 and HtrA2 following ONC. PMID: 27748880
    4. Hax-1 is a family of anti- and proapoptotic regulators that may modulate cell survival and death through homo- or heterodimerization. PMID: 24347163
    5. Results suggest that Hax-1 may be involved in the pathophysiology of TBI and further research is needed to have a good understanding of its function and mechanism. PMID: 21136158
    6. HAX-1 is a multifaceted antiapoptotic protein localizing in the mitochondria and the sarcoplasmic reticulum of striated muscle cells PMID: 19913549
    7. The existence of at least three protein isoforms was confirmed. PMID: 16516414

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  • 亚细胞定位：
    Mitochondrion. Endoplasmic reticulum. Nucleus membrane. Cytoplasmic vesicle. Cytoplasm, cell cortex. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Sarcoplasmic reticulum. Cytoplasm, P-body. Cytoplasm. Nucleus.; [Isoform 1]: Cytoplasm. Nucleus.
  • 蛋白家族：
    HAX1 family
  • 组织特异性：
    Present in striated muscles (at protein level).
  • 数据库链接：

    KEGG: rno:291202

    STRING: 10116.ENSRNOP00000067159

    UniGene: Rn.185269