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  4. Recombinant Rat Interleukin-1 alpha (Il1a)

Recombinant Rat Interleukin-1 alpha (Il1a)

  • 货号：
    CSB-YP011613RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP011613RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP011613RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP011613RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP011613RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Il1a; Interleukin-1 alpha; IL-1 alpha
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    115-270
  • 氨基酸序列
    SAPHSF QNNLRYKLIR IVKQEFIMND SLNQNIYVDM DRIHLKAASL NDLQLEVKFD MYAYSSGGDD SKYPVTLKVS NTQLFVSAQG EDKPVLLKEI PETPKLITGS ETDLIFFWEK INSKNYFTSA AFPELLIATK EQSQVHLARG LPSMIDFQIS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
  • 基因功能参考文献：
    1. Extracellular high-mobility group box-1 (HMGB1) was identified as the likely endogenous regulator of IL1 expression after injury PMID: 26899371
    2. IL-1alpha-induced expression of C/EBPbeta and SDF-1 was significantly potentiated by knockdown of transforming growth factor beta-activated kinase 1 (TAK1), an upstream activator of IKKbeta signaling, in vascular smooth muscle cells. PMID: 26002466
    3. There is increased expression of Il-1alpha in the spinal cord 1 day after painful facet joint injury. PMID: 24253784
    4. It can be concluded that GERD with increased cytokines and inflammatory cells in lung could cause or exacerbate asthma and pulmonary fibrosis. PMID: 24338227
    5. The findings of the present study suggest that part of ischemic injury in the embolic stroke may be mediated through the increased levels of inflammatory cytokines. PMID: 24338258
    6. Streptococcus pneumoniae infection promotes atherogenesis and exacerbates inflammatory responses to cerebral ischemia, leading to increased brain injury via platelets and interleukin (IL) 1. PMID: 24644058
    7. Therefore, systemic modulation of the immune response by hUCB cells could represent one possible mechanism of how these cells might mediate their beneficial effects. PMID: 23123184
    8. Sertoli cells treated with IL-1alpha revealed changes in cellular distribution of actin filaments compared to untreated cells. Increase in the kinetics of occludin internalization but decrease in its rate of degradation was noted following IL-1alpha treatment. PMID: 21191089
    9. Regulatory enhancer binding protein transcription factor AP-1 binding to the IL1A -889 polymorphic locus has been characterized. PMID: 22634325
    10. Data show that MDMA produces changes in IL-1 signal modulators which are modified by CB2 receptor activation, and indicate that IL-1beta may play a partial role in MDMA-induced neurotoxicity. PMID: 21595923
    11. Abnormal expression of the selected interleukins is associated with low placental weight and decrease of its thickness, especially labyrinth zone, as well as with high maternal urea level. PMID: 20529813
    12. data demonstrate that the cyclooxygenase 2 cascade is a regulator of IL-1 alpha,IL-1 beta and IL-6 mRNA in Leydig progenitors PMID: 12193539
    13. produced in and secreted by rat testis PMID: 12270120
    14. the changes of IL-1 and NO levels in the testes of rats with varicocele might be the reason which caused testes damage, disturbance of spermatogenesis and even infertility. PMID: 12479028
    15. there is a differential expression of calpain I and II under pathological conditions induced either by endotoxin stimuli or Leydig cell depletion, which may produce a differential effect on IL-1alpha processing. PMID: 12534936
    16. Lipopolysaccharides (endotoxins) stimulate expression of this inflammatory cytokine in skeletal muscle. PMID: 12785009
    17. IL-1alpha and IL-2 produce an increase of glucose metabolism in uteri isolated from underfed rats PMID: 12878449
    18. Interleukin-1alpha produces an increase of glucose metabolism in uteri isolated from underfed rats by two different mechanisms, both involving COX-2: (1) nitric oxide independent and (2) nitric oxide dependent PMID: 14643175
    19. Data suggest that gamma-hexachlorocyclohexane-induced liver oxidative stress triggers DNA binding activity of NF-kappaB, with a consequent increase in expression of NF-kappaB-dependent genes for tumor necrosis factor-alpha and interleukin-1alpha. PMID: 15025948
    20. This review summarizes the findings in rats that isoforms of IL-1alpha may serve as paracrine mediators, alone or in concert with other factors, that support proper testicular cell functioning and, thereby, reproduction and fertility. PMID: 15032628
    21. We conclude that the pro-inflammatory cytokines IL-1beta and TNFalpha inhibit electrogenic sodium absorption in rat distal colon by mRNA expression regulation of the beta- and gamma-ENaC subunits. PMID: 15063785
    22. interleukin-1alpha (IL-1alpha) is a proinflammatory cytokine that has also been found to act as a paracrine mediator involved in the regulation of testicular functions [review] PMID: 15154090
    23. sympathetic nerves have an inhibitory effect on IL-1 alpha in periapical lesions and a stimulatory effect on TNF-alpha in the intact rat pulp. PMID: 15467353
    24. The differential effects of recombinant rat IL-1 alpha and IL-1 beta on mouse cultured glial cells are mediated by alternative pathways to the classical IL-1 signaling cascade. PMID: 15671867
    25. the IL1A and il10 genesw are substantially related to the development of cat exposure-induced allergy PMID: 15990800
    26. These results show that IL-1alpha and IL-1beta play important roles in the TBI-induced loss of hippocampal neurons. PMID: 16083355
    27. The increased expression of IL-1alpha and IL-1beta in varicocele shifts the balance in favor of inflammatory and immune responses and causes detrimental effects in testis tissue, which may cause male infertility. PMID: 16616101
    28. Normal IL-1 signaling is required for the production of brain PGE(2) under basal conditions and in response to surgical stress. PMID: 16825798
    29. Tyr-542 of SHP-2 modulates IL-1-induced Ca2+ signals and association of the ER with focal adhesions PMID: 16905534
    30. IL-1 is the proinflammatory mediator responsible for the reduced level of phosphorylated eIF4G PMID: 17117141
    31. Functionally active IL-1alpha is present on the cell surface of neonatal rat cardiomyocytes suggesting a differential role of IL-1alpha in regulation of cellular functions during development, aging and disease in rat and human heart cells. PMID: 17621543
    32. Localized production of IL1A by Sertoli and/or germ cells in vivo results in BTB restructuring. PMID: 18057314
    33. IL-1alpha was significantly more efficient than IL-1beta at up-regulating SP expression than IL-1beta. Taken together, these observations suggest an important role for IL-1alpha in the events following nerve injury. PMID: 19341730
    34. Bacterial lipopolysaccharide increased the production of interleukin 1alpha and activin A, and reduced production of inhibin B, in Sertoli cells from immature male rats. PMID: 19524137
    35. Data show that with the help of negative regulators TGF-beta and FasL, the high levels of IL-1alpha and IL-6 expressions were observed in the early stages of the infection, and decreased gradually in the later weeks both in vitro and in vivo. PMID: 19567205

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  • 亚细胞定位：
    Cytoplasm. Secreted.
  • 蛋白家族：
    IL-1 family
  • 数据库链接：

    KEGG: rno:24493

    STRING: 10116.ENSRNOP00000006113

    UniGene: Rn.12300