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  4. Recombinant Rat Metallothionein-2 (Mt2)

Recombinant Rat Metallothionein-2 (Mt2)

  • 中文名称：
    大鼠Mt2重组蛋白
  • 货号：
    CSB-YP356242RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Mt2重组蛋白
  • 货号：
    CSB-EP356242RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Mt2重组蛋白
  • 货号：
    CSB-EP356242RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Mt2重组蛋白
  • 货号：
    CSB-BP356242RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Mt2重组蛋白
  • 货号：
    CSB-MP356242RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mt2
  • Uniprot No.：
  • 别名：
    Mt2; Metallothionein-2; MT-2; Metallothionein-II; MT-II
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-61
  • 氨基酸序列
    MDPNCSCATD GSCSCAGSCK CKQCKCTSCK KSCCSCCPVG CAKCSQGCIC KEASDKCSCC A
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
  • 基因功能参考文献：
    1. acute attack of experimental autoimmune encephalomyelitis was followed by increased expression of metallothioneins in molecular and granular cell layer of hippocampus. PMID: 27173051
    2. observe a huge increase in MT3 transcripts in both cortical and hippocampal areas, while the MT1/2 mRNA content increases slightly, returning to the levels measured in adolescent rats PMID: 27939232
    3. MT-I/II are required for the conditioning lesion effect and can promote axonal regeneration in the injured central nervous system. PMID: 25947372
    4. endogenous MT-I/II might play an important role in the pathogenesis of pain behaviors, participating in the initiation of inflammatory and neuropathic pain rather than in their maintenance PMID: 23726995
    5. Metallothionein-2 expression is regulated by psychological stress in adult male and female rats. PMID: 23291980
    6. Zinc pre-treatment improved MT-1 and MT-2 gene expressions in kidney which significantly alleviated acute toxicity of depleted uranium. PMID: 22703381
    7. The MT mRNA level displays isoform-specific changes: those of MT-1 do not change appreciably, whereas those of MT-2 increase significantly in 2-hr endotoxemia, with or without obstructive jaundice. PMID: 22100509
    8. Expression of MT2 in the adult rat testes and during development PMID: 20109269
    9. The solution structures of Cd(3)-thiolate cluster containing beta-domain of mouse beta-MT-1 and rat beta-MT-2 show high structural similarities, but widely differing structure dynamics. PMID: 19609577
    10. Results provide evidence for the heterogeneous distribution of MT(2) receptors in different parts and layers of the gastrointestinal tract, which could indicate a physiological role of melatonin in the gastrointestinal tract. PMID: 19004484
    11. TTR-MT1/2 complexes may be functionally significant not only in healthy conditions but also in Abeta deposition in Alzheimer disease. PMID: 18237193

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  • 蛋白家族：
    Metallothionein superfamily, Type 1 family
  • 数据库链接：

    KEGG: rno:689415

    STRING: 10116.ENSRNOP00000062585

    UniGene: Rn.115549