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  4. Recombinant Rat Microtubule-associated proteins 1A/1B light chain 3A (Map1lc3a)

Recombinant Rat Microtubule-associated proteins 1A/1B light chain 3A (Map1lc3a)

  • 中文名称：
    大鼠Map1lc3a重组蛋白
  • 货号：
    CSB-YP747701RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Map1lc3a重组蛋白
  • 货号：
    CSB-EP747701RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Map1lc3a重组蛋白
  • 货号：
    CSB-EP747701RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Map1lc3a重组蛋白
  • 货号：
    CSB-BP747701RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Map1lc3a重组蛋白
  • 货号：
    CSB-MP747701RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Map1lc3a
  • Uniprot No.：
  • 别名：
    Map1lc3aMicrotubule-associated proteins 1A/1B light chain 3A; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A; MAP1A/MAP1B LC3 A; Microtubule-associated protein 1 light chain 3 alpha
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-120
  • 氨基酸序列
    MPSDRPFKQR RSFADRCKEV QQIRDQHPSK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM SELVKIIRRR LQLNPTQAFF LLVNQHSMVS VSTPIADIYE QEKDEDGFLY MVYASQETFG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
  • 基因功能参考文献：
    1. We found that both bafilomycin and chloroquine could significantly increase the autophagosome marker LC3-II and inhibit key parameters of mitochondrial function, and increase mtDNA damage. PMID: 27889640
    2. autophagy of cytoplasmic bulk cargo was completely LC3 independent. PMID: 26237084
    3. LC3B modulates Angiotensin II-induced cardiomyocyte hypertrophy in cultured ventricular cardiomyocytes. PMID: 26284810
    4. Our findings indicate that increased autophagy in the cerebellum of dogs naturally infected with CDV may play a role in transferring the virus from cell to cell. PMID: 26179070
    5. the addition of amino acids to the starvation condition, a similar quick signal appeared by significant reduction of the LC3 ratio and bulk proteolysis. PMID: 25062852
    6. The protein expression level of the autophagy marker light chain 3/Atg8 exhibited a marked decline in aged kidneys. PMID: 21455601
    7. the effect of a single bout of running exercise, which augments cardiac work transiently and physiologically, on the expression of microtubule-associated protein 1 light chain 3 , an indicator of autophagy, in the rat cardiac muscle was studied. PMID: 22005460
    8. These studies provided evidence that miR-204 played an important role in regulating autophagy through LC3-IIprotein during ischemia-reperfusion. PMID: 21631941
    9. p62 directly binds to the evolutionarily conserved cargo receptor-binding domain of Atg8/LC3 and selectively mediates the clearance of mutant Huntingtin. PMID: 20204693
    10. These findings indicate that LC3 is involved in the lipid droplet formation regardless of the bulk degradation, and that LC3 has two pivotal roles in cellular homeostasis mediated by autophagy and lipid metabolism. PMID: 20132792

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome.
  • 蛋白家族：
    ATG8 family
  • 数据库链接：

    KEGG: rno:362245

    STRING: 10116.ENSRNOP00000032429

    UniGene: Rn.3135