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  4. Recombinant Rat Peroxiredoxin-6 (Prdx6)

Recombinant Rat Peroxiredoxin-6 (Prdx6)

  • 中文名称：
    大鼠Prdx6重组蛋白
  • 货号：
    CSB-YP018659RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Prdx6重组蛋白
  • 货号：
    CSB-EP018659RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Prdx6重组蛋白
  • 货号：
    CSB-EP018659RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Prdx6重组蛋白
  • 货号：
    CSB-BP018659RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Prdx6重组蛋白
  • 货号：
    CSB-MP018659RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Prdx6
  • Uniprot No.：
  • 别名：
    Prdx6; Aipla2; Aop2; TsaPeroxiredoxin-6; EC 1.11.1.15; 1-Cys peroxiredoxin; 1-Cys PRX; Acidic calcium-independent phospholipase A2; aiPLA2; EC 3.1.1.4; Antioxidant protein 2; Non-selenium glutathione peroxidase; NSGPx; Thiol-specific antioxidant protein
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-224
  • 氨基酸序列
    PGGLLLGDE APNFEANTTI GHIRFHDFLG DSWGILFSHP RDFTPVCTTE LGRAAKLAPE FAKRNVKLIA LSIDSVEDHF AWSKDINAYN GAAPTEKLPF PIIDDKDRDL AILLGMLDPA EKDEKGMPVT ARVVFIFGPD KKLKLSILYP ATTGRNFDEI LRVVDSLQLT ASNPVATPVD WKKGESVMVL PTLPEEEAKQ LFPKGVFTKE LPSGKKYLRY TPQP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate.
  • 基因功能参考文献：
    1. Prdx6 upregulation by Cur treatment attenuates ischemic oxidative damage through SP1 induction in rats after stroke. This represents a novel mechanism of Cur-induced neuroprotection against cerebral ischemia. PMID: 28596967
    2. Prdx1 and Prdx6 proteins is involved in pulmonary fibrosis induced by silica. PMID: 27660222
    3. Data suggest the peroxiredoxin 6 (PRDX6) in microglia protects neuron against oxygen-glucose deprivation and reoxygenation (OGD/R)-induced injury. PMID: 27412928
    4. PRDX6 may serve as a biomarker for traumatic brain injury and that autoimmune profiling is a viable strategy for the discovery of novel biomarkers PMID: 25938937
    5. Our present findings illustrate the molecular changes during radiation-induced skin injury and the important role of PRDX-6 in ameliorating this damage in rats PMID: 24447893
    6. PRDX6 is an important enzyme for the protection against oxidative stress. PMID: 23623867
    7. a change in the conformation of Prdx6 upon its phosphorylation is the basis for enhancement of PLA(2) enzymatic activity PMID: 22663767
    8. Prdx 6 expression in rat brain continually increased in the perinatal period. Dexamethasone injection increased the expression of Prdx 6. PMID: 22166015
    9. SP-A and Prdx6 directly interact, which provides a mechanism for regulation of the PLA(2) activity of Prdx6 by SP-A PMID: 16330552
    10. Prx I and VI play a crucial role against oxidative stress in vascular smooth muscles during hypertension PMID: 17556052
    11. The native 1-Cys Prx existed in the monomeric and dimeric forms. PMID: 17633531
    12. analysis of the peroxiredoxin 6 catalytic triad and its role in phospholipid substrate binding PMID: 17652308
    13. Show PRDX6 down-regulation is associated with cataractogenesis and that genetic transduction of PRDX6 can delay cataracts. PMID: 18184874
    14. PRDX6 protected retinal ganglion cells from glutamate and TNF-alpha induced cytotoxicity by reducing reactive oxygen species level and NF-kappaB activation, and limiting increased intracellular Ca2+ influx. PMID: 18694738
    15. The MAPKs can mediate phosphorylation of Prdx6 at Thr-177 with a consequent marked increase in its aiPLA(2) activity. PMID: 19140803
    16. An extrinsic supply of recombinant TAT-PRDX5 and -6 proteins is responsible for inhibiting hyperglycemia-induced retinal pericyte apoptosis. PMID: 19351539

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  • 亚细胞定位：
    Cytoplasm. Lysosome.
  • 蛋白家族：
    Peroxiredoxin family, Prx6 subfamily
  • 数据库链接：

    KEGG: rno:94167

    STRING: 10116.ENSRNOP00000030323

    UniGene: Rn.42