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  4. Recombinant Rat Protein NDRG2 (Ndrg2)

Recombinant Rat Protein NDRG2 (Ndrg2)

  • 中文名称：
    大鼠Ndrg2重组蛋白
  • 货号：
    CSB-YP819733RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Ndrg2重组蛋白
  • 货号：
    CSB-EP819733RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Ndrg2重组蛋白
  • 货号：
    CSB-EP819733RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Ndrg2重组蛋白
  • 货号：
    CSB-BP819733RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Ndrg2重组蛋白
  • 货号：
    CSB-MP819733RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ndrg2
  • Uniprot No.：
  • 别名：
    Ndrg2; Protein NDRG2; Antidepressant-related protein ADRG123; N-myc downstream-regulated gene 2 protein; NDRG1-related protein
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-371
  • 氨基酸序列
    AELQEVQIT EEKPLLPGQT PEAAKEAELA ARILLDQGQT HSVETPYGSV TFTVYGTPKP KRPAIFTYHD VGLNYKSCFQ PLFQFGDMQE IIQNFVRVHV DAPGMEEGAP VFPLGYQYPS QDQLADMIPC ILQYLNFSTI IGVGVGAGAY ILSRYALNHP DTVEGLVLIN IDPNAKGWMD WAAHKLTGLT SSIPEMILGH LFSQEELSGN SELIQKYRSL ITHAPNLENI ELYWNSYNNR RDLNFERGGE MTLKCPVMLV VGDQAPHEDA VVECNSKLDP TQTSFLKMAD SGGQPQLTQP GKLTEAFKYF VQGMGYMASS CMTRLSRSRT ASLTSAASID GSRSRSRTLS QSSESGTLPS GPPGHTMEVS C
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.
  • 基因功能参考文献：
    1. Increased level of NDRG2 in cortex or hippocampus may be a potential risk for Alzheimer's disease. NDRG2 increased Abeta1-42 might be related to the changes of BEAC1 and GGA3. It might also affect CDK5 and tau overphosphorylation. NDRG2 interacting with STAT3 and modulating Fas/Fasl signaling pathway plays important roles in cell death. PMID: 28670853
    2. Our results demonstrated that NDRG2 promoted secreted miR-375 in microvesicles shed from M1 microglia, which induced neuron damage. PMID: 26631961
    3. We further showed that the localized delivery of NDRG2 improved the dysfunction of Na(+) and Cl(-) reabsorption PMID: 24343104
    4. Our results indicated that NDRG2 is involved in anti-apoptosis induced by electroacupuncture pretreatment after focal cerebral ischemia in rats PMID: 23540409
    5. Results suggest a novel role of PI3K/Akt/NDRG2 signaling in the cardioprotective effect of insulin. PMID: 23463182
    6. Western blot analysis showed that the chronic stress downregulated GFAP but upregulated NDRG2 protein PMID: 22610521
    7. NDRG2 expression is up-regulated in ischemic penumbra following transient focal cerebral ischemia; NDRG2 expression in astrocytes may play an important pathological role in cell apoptosis after stroke. PMID: 21241684
    8. A low level of NDRG2 was observed as the C-Myc expression increased during regeneration. Moreover, a dramatic cell cycle arrest was found in normal rat liver-derived BRL cells 48 hours after being infected by adenoviral vectors expressing rat NDRG2. PMID: 20840522
    9. results indicate that NDRG2 regulation by aldosterone is an early mineralocorticoid-specific effect PMID: 12072429
    10. Review concludes that the study of Ndrg2 regulation and function in glia could contribute to understanding the pathogenesis and treatment of depression. PMID: 14993068
    11. NDRG2 is a likely candidate to contribute to aldosterone-mediated ENaC regulation PMID: 17652085
    12. These findings suggest that NDRG2 regulates testicular development and spermatogenesis in rats and is involved in the physiological and pathological apoptosis of germ cells. PMID: 19471968

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In neurons, seems to concentrate at axonal growth cone.
  • 蛋白家族：
    NDRG family
  • 组织特异性：
    Broadly expressed, with highest levels in heart, liver, skeletal muscle and aorta.
  • 数据库链接：

    KEGG: rno:171114

    STRING: 10116.ENSRNOP00000042949

    UniGene: Rn.3407