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  4. Recombinant Rat Regulator of G-protein signaling 2 (Rgs2)

Recombinant Rat Regulator of G-protein signaling 2 (Rgs2)

  • 中文名称：
    大鼠Rgs2重组蛋白
  • 货号：
    CSB-YP878054RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Rgs2重组蛋白
  • 货号：
    CSB-EP878054RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Rgs2重组蛋白
  • 货号：
    CSB-EP878054RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Rgs2重组蛋白
  • 货号：
    CSB-BP878054RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Rgs2重组蛋白
  • 货号：
    CSB-MP878054RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Rgs2; Regulator of G-protein signaling 2; RGS2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-211
  • 氨基酸序列
    MQSAMFLAVQ HDCVPMDKSA GNGPKVEEKR EKMKRTLLKD WKTRLSYFLQ NSSTPGKPKT GKKSKQQTFI KPSPEEALLW AEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK KPQITTEPHA T
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
  • 基因功能参考文献：
    1. These results suggest that Dahl S rats exhibit a blunted RGS2 response to Ang-II, and this blunted response may be partially responsible for the susceptibility to renal injury in Dahl S rats. PMID: 26606876
    2. The protective effects of RGS2 in cardiac hypertrophy may derive at least in part from its ability to govern protein synthesis. PMID: 24576550
    3. RGS2 functions on a daily basis to negatively modulate melatonin production PMID: 23523917
    4. Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 PMID: 22057271
    5. Ischemic stress increases RGS2 expression and that this condition contributes to enhanced apoptosis in C6 cells and primary astrocytes. PMID: 20032508
    6. Analysis of regulator of G-protein signaling-2 (RGS-2) expression and function in osteoblastic cells. PMID: 11968023
    7. RGS2 is expressed in the neocortex, piriform cortex, caudate-putamen, septum, hippocampus, and locus coeruleus. RGS2 is not involved in the hypersensitization of postsynaptic dopamine receptors observed after lesion of the nigrostriatal pathway. PMID: 12207953
    8. D1 and D2 receptors exert opposite effects on RGS2 expression, as they do on cAMP levels, suggesting a cAMP-mediated transcription of RGS2 in the corpus striatum PMID: 12603835
    9. Sex steroids (progesterone) and presence of conceptus play role in regulation of myometrial RGS2. Myometrial RGS2 is elevated when uterus is quiescent. Down-regulation of RGS2 at end of pregnancy may be related to timing of parturition. PMID: 12712095
    10. Regulation of RGS-2 may constitute a novel mechanism by which steroids modulate signaling via the PTH/PTHrP receptor and other G protein-coupled receptors in bone. PMID: 12746312
    11. group VIA phospholipase A2 (iPLA2beta) plays a pivotal role in Ang II-induced RGS2 mRNA up-regulation in vascular smooth muscle cells PMID: 17613534
    12. After 2 days of aortic banding-induced hypertrophy, thoracic aorta lost expression of Rgs2 , it returned to normal at 1 week and increased many fold at 28 days, indicating that RGS expression and function correlate with vascular remodeling. PMID: 18207159
    13. S1P induces RGS2 and RGS16 mRNA expression but uses distinct S1P receptor subtypes and signalling pathways to regulate expression of these RGS proteins PMID: 19374869

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  • 亚细胞定位：
    Cell membrane. Cytoplasm. Nucleus, nucleolus.
  • 数据库链接：

    KEGG: rno:84583

    STRING: 10116.ENSRNOP00000005156

    UniGene: Rn.1892