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  4. Recombinant Rat Reticulon-4 receptor-like 2 (Rtn4rl2)

Recombinant Rat Reticulon-4 receptor-like 2 (Rtn4rl2)

  • 中文名称：
    大鼠Rtn4rl2重组蛋白
  • 货号：
    CSB-YP800349RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Rtn4rl2重组蛋白
  • 货号：
    CSB-EP800349RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Rtn4rl2重组蛋白
  • 货号：
    CSB-EP800349RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Rtn4rl2重组蛋白
  • 货号：
    CSB-BP800349RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Rtn4rl2重组蛋白
  • 货号：
    CSB-MP800349RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rtn4rl2
  • Uniprot No.：
  • 别名：
    Rtn4rl2; Ngrh1; Reticulon-4 receptor-like 2; Nogo receptor-like 3; Nogo-66 receptor homolog 1; Nogo-66 receptor-related protein 2; NgR2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    31-390
  • 氨基酸序列
    CPMLCTCYSS PPTVSCQANN FSSVPLSLPP STQRLFLQNN LIRSLRPGTF GPNLLTLWLF SNNLSTIYPG TFRHLQALEE LDLGDNRHLR SLEPDTFQGL ERLQSLHLYR CQLSSLPGNI FRGLVSLQYL YLQENSLLHL QDDLFADLAN LSHLFLHGNR LRLLTEHVFR GLGSLDRLLL HGNRLQGVHR AAFHGLSRLT ILYLFNNSLA SLPGEALADL PALEFLRLNA NPWACDCRAR PLWAWFQRAR VSSSDVTCAT PPERQGRDLR TLRDTDFQAC PPPTPTRPGS RARGNSSSNH LYGVAEAGAP PADPSTLYRD LPAEDSRGRQ GGDAPTEDDY WGGYGGEDQR GEQTCPGAAC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG. Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton.
  • 基因功能参考文献：
    1. crystal structure of the leucine-rich repeat region and part of the stalk regions of NgR2 and comparison to the previously reported NgR1 structure with respect to the distinct signaling properties of the two receptor isoforms PMID: 21308849
    2. Downregulation of Nogo receptor(NgR) after kainic acid or wheel-running in cortex and hippocampus suggests a role for NgR and Nogo-A in plasticity, learning and memory. PMID: 12658441
    3. The s' results indicate that severed rubrospinal axons respond to NEP1-40 treatment but less robustly than corticospinal, raphe-spinal, or dorsal root axons. PMID: 18056009
  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Cell projection, dendrite. Perikaryon. Cell projection, axon. Membrane raft.
  • 蛋白家族：
    Nogo receptor family
  • 组织特异性：
    Detected in adult brain, in neocortex, hippocampus, striatum and dorsal root ganglion neurons, and in retina (at protein level). In brain, detected in cerebral cortex and hippocampus. Weak or no expression detected in the cerebellum, thalamus or striatum.
  • 数据库链接：

    KEGG: rno:311169

    STRING: 10116.ENSRNOP00000032922

    UniGene: Rn.162683