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  4. Recombinant Rat Voltage-dependent L-type calcium channel subunit beta-2 (Cacnb2)

Recombinant Rat Voltage-dependent L-type calcium channel subunit beta-2 (Cacnb2)

  • 中文名称：
    Recombinant Rat Voltage-dependent L-type calcium channel subunit beta-2(Cacnb2),Yeast
  • 货号：
    CSB-YP837733RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Voltage-dependent L-type calcium channel subunit beta-2(Cacnb2),Yeast
  • 货号：
    CSB-EP837733RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Voltage-dependent L-type calcium channel subunit beta-2(Cacnb2),Yeast
  • 货号：
    CSB-EP837733RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Voltage-dependent L-type calcium channel subunit beta-2(Cacnb2),Yeast
  • 货号：
    CSB-BP837733RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Voltage-dependent L-type calcium channel subunit beta-2(Cacnb2),Yeast
  • 货号：
    CSB-MP837733RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cacnb2; Cacnlb2; Voltage-dependent L-type calcium channel subunit beta-2; CAB2; Calcium channel voltage-dependent subunit beta 2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-655
  • 氨基酸序列
    MVQSDTSKSP PIAAVAQESQ MELLESAAPA GALGAQSYGK GARRKNRFKG SDDSTSSDTT SNSFVRQGSA DSYTSRPSDS DVSLEEDREA VRREAERQAQ AQLEKAKTKP VAFAVRTNVR YSAAQEDDVP VPGMAISFEA KDFLHVKEKF NNDWWIGRLV KEGCEIGFIP SPVKLENMRL QHEQRAKQGK FYSSKSGGNS SSSLGDIVPS SRKSTPPSSA IDIDATGLDA EENDIPANHR SPKPSANSVT SPHSKEKRMP FFKKTEHTPP YDVVPSMRPV VLVGPSLKGY EVTDMMQKAL FDFLKHRFEG RISITRVTAD ISLAKRSVLN NPSKHAIIER SNTRSSLAEV QSEIERIFEL ARTLQLVVLD ADTINHPAQL SKTSLAPIIV YVKISSPKVL QRLIKSRGKS QAKHLNVQMV AADKLAQCPP QESFDVILDE NQLEDACEHL ADYLEAYWKA THPPSSNLPN PLLSRTLATS TLPLSPTLAS NSQGSQGDQR TDRSAPRSAS QAEEEPCLEP VKKSQHRSSS ATHQNHRSGT GRGLSRQETF DSETQESRDS AYVEPKEDYS HEHVDRYVPH REHNHREESH SSNGHRHREP RHRTRDMGRD QDHNECSKQR SRHKSKDRYC DKEGEVISKR RSEAGEWNRD VYIRQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
  • 基因功能参考文献：
    1. these findings provide evidence for a new role of Homer1 supporting the regulation of Cav1.2 channels by STIM1. PMID: 25712868
    2. Cacnb2 is selectively targeted to the axon terminals of supraoptic neurons. PMID: 24755552
    3. a model in which CaVbeta promotes anterograde trafficking of the L-type channels by anchoring them to actin filaments in their itinerary to the plasma membrane. PMID: 25533460
    4. analysis of how voltage-gated calcium channel beta2e-subunit N-terminal domain is tethered to the plasma membrane via electrostatic and hydrophobic interactions PMID: 24519939
    5. Data show that ablation of L-type calcium channels partially blocks Akt inhibition-induced reduction in glucose-stimulated insulin secretion but completely prevents that in potassium depolarization-evoked insulin release from INS-1 cells. PMID: 21792084
    6. Cardiac L-type Ca channel beta2 subunit protein expression may be downregulated by miRs in response to long-term activation of beta-adrenergic signaling, possibly as an adaptive response in cardiac hypertrophy and sustained beta-adrenergic states. PMID: 21753737
    7. Beta subunits play a role in PKA modulation of Ca(V)1.2 channels and uncover a new design principle of this phenomenon in the heart, vis a vis a limited functional reserve. PMID: 18356540
    8. This study provides the first evidence to demonstrate that LTCC beta2 subunit is coupled with the movement of signals in the mechanism of activation of NKA-mediated crosstalk with LTCC. PMID: 20937253
    9. CaMKII specifically binds to CaV1.2 L-type calcium channels by the beta(1b) or beta(2a) subunits. PMID: 19840220
    10. a novel function for the beta-subunit through its Src homology 3 domain and establish a link between voltage-gated calcium channel activity and the cell endocytic machinery PMID: 17110381

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  • 亚细胞定位：
    Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Calcium channel beta subunit family
  • 组织特异性：
    Highly expressed in heart and brain, and at lower levels in lung.
  • 数据库链接：

    KEGG: rno:116600

    STRING: 10116.ENSRNOP00000037354

    UniGene: Rn.10739