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  4. Recombinant Saccharomyces cerevisiae Probable histone deacetylase HOS2 (HOS2)

Recombinant Saccharomyces cerevisiae Probable histone deacetylase HOS2 (HOS2)

  • 中文名称：
    酿酒酵母HOS2重组蛋白
  • 货号：
    CSB-YP346819SVG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    酿酒酵母HOS2重组蛋白
  • 货号：
    CSB-EP346819SVG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    酿酒酵母HOS2重组蛋白
  • 货号：
    CSB-EP346819SVG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    酿酒酵母HOS2重组蛋白
  • 货号：
    CSB-BP346819SVG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    酿酒酵母HOS2重组蛋白
  • 货号：
    CSB-MP346819SVG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HOS2
  • Uniprot No.：
  • 别名：
    HOS2; YGL194C; G1330; Probable histone deacetylase HOS2; EC 3.5.1.98
  • 种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-452
  • 氨基酸序列
    MSGTFSYDVK TKENEPLFEF NSAYSPRVSY HFNSKVSHYH YGVKHPMKPF RLMLTDHLVS SYGLHKIMDL YETRSATRDE LLQFHSEDYV NFLSKVSPEN ANKLPRGTLE NFNIGDDCPI FQNLYDYTTL YTGASLDATR KLINNQSDIA INWSGGLHHA KKNSPSGFCY VNDIVLSILN LLRYHPRILY IDIDLHHGDG VQEAFYTTDR VFTLSFHKYN GEFFPGTGDL TEIGCDKGKH FALNVPLEDG IDDDSYINLF KSIVDPLIMT FKPTLIVQQC GADSLGHDRL GCFNLNIKAH GECVKFVKSF GLPMLVVGGG GYTPRNVSRL WTYETGILND VLLPEDIPED IPFRDSFGPD YSLYPMLDDL YENKNSKKLL EDIRIRCLEN IRYLQGAPSV RMDAECIPTQ DISALTEEED KIIQEMNEET EADSSNRLEE MEKENSGLIA FS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). It is apparently involved in transcriptional activation.
  • 基因功能参考文献：
    1. These results uncover an unexpected role for histone deacetylases (Rpd3 and Hos2) in promoting Spt6 interaction with elongating Pol II. PMID: 25182531
    2. observed the formation of a reversible cytosolic "stationary-phase granule" by Hos2, a nuclear histone deacetylase. In the stationary phase, hos2 mutants display reduced viability. PMID: 22337769
    3. both Elp3-induced acetylation and Hos2-induced deacetylation influence the nucleosome positions in the promoters of 24 genes PMID: 21297980
    4. Hos2 and Set3 function at tRNA genes to promote Ty1 integration PMID: 16415356
    5. Two histone deacetylases, RPD3 and HOS2, are required for the activation of DNA damage-inducible genes RNR3 and HUG1. PMID: 17296735
    6. the Hos2p/Set3p complex (SET3C) is a novel component critical for cell survival in response to secretory stress. PMID: 18487345

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Histone deacetylase family, HD type 1 subfamily
  • 数据库链接：

    KEGG: sce:YGL194C

    STRING: 4932.YGL194C