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  4. Recombinant Salmonella typhimurium Guanine nucleotide exchange factor sopE2 (sopE2)

Recombinant Salmonella typhimurium Guanine nucleotide exchange factor sopE2 (sopE2)

  • 中文名称：
    鼠伤寒沙门菌sopE2重组蛋白
  • 货号：
    CSB-YP765893SXB
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    鼠伤寒沙门菌sopE2重组蛋白
  • 货号：
    CSB-EP765893SXB
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    鼠伤寒沙门菌sopE2重组蛋白
  • 货号：
    CSB-EP765893SXB-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    鼠伤寒沙门菌sopE2重组蛋白
  • 货号：
    CSB-BP765893SXB
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    鼠伤寒沙门菌sopE2重组蛋白
  • 货号：
    CSB-MP765893SXB
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    sopE2
  • Uniprot No.：
  • 别名：
    sopE2; STM1855; Guanine nucleotide exchange factor sopE2; Effector protein sopE2; Toxin sopE2
  • 种属：
    Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-240
  • 氨基酸序列
    TNITLSTQH YRIHRSDVEP VKEKTTEKDI FAKSITAVRN SFISLSTSLS DRFSLHQQTD IPTTHFHRGN ASEGRAVLTS KTVKDFMLQK LNSLDIKGNA SKDPAYARQT CEAILSAVYS NNKDQCCKLL ISKGVSITPF LKEIGEAAQN AGLPGEIKNG VFTPGGAGAN PFVVPLIASA SIKYPHMFIN HNQQVSFKAY AEKIVMKEVT PLFNKGTMPT PQQFQLTIEN IANKYLQNAS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Activator for CDC42 by directly engaging this Rho GTPase and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells. Also activates NF-kB, p38 and ERK kinases, which are known to be involved in the induction of IL-8 expression. Chaperone InvB is required for secretion, translocation and stabilization of intracellular levels of sopE2.
  • 基因功能参考文献：
    1. Data show that the chaperone binding domain inhibits secretion of wild-type SopE via the flagellar and the SPI-1 Type III secretion systems in the absence of the chaperone InvB. PMID: 16359332
    2. These findings implicate SopE-driven Rho GTPase-mediated caspase-1 activation in stromal cells as a mechanism eliciting mucosal inflammation during Salmonella typhimurium infection. PMID: 19683679
  • 亚细胞定位：
    Secreted. Note=Secreted via the type III secretion system 1 (SPI-1 TTSS).
  • 蛋白家族：
    GEF (guanine exchange factor) SopE family
  • 数据库链接：

    KEGG: stm:STM1855

    STRING: 99287.STM1855