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  4. Recombinant Xenopus laevis Pancreas transcription factor 1 subunit alpha (ptf1a)

Recombinant Xenopus laevis Pancreas transcription factor 1 subunit alpha (ptf1a)

  • 中文名称：
    有爪蟾蜍ptf1a重组蛋白
  • 货号：
    CSB-YP684248XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    有爪蟾蜍ptf1a重组蛋白
  • 货号：
    CSB-EP684248XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    有爪蟾蜍ptf1a重组蛋白
  • 货号：
    CSB-EP684248XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    有爪蟾蜍ptf1a重组蛋白
  • 货号：
    CSB-BP684248XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    有爪蟾蜍ptf1a重组蛋白
  • 货号：
    CSB-MP684248XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ptf1a
  • Uniprot No.：
  • 别名：
    ptf1a; Pancreas transcription factor 1 subunit alpha; Pancreas-specific transcription factor 1a; Transcription factor Ptf1a/p48
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-270
  • 氨基酸序列
    METVLEQLAG LESFPSPYFD EDDFFTDHSS RDALDADDFL EDDVDFLAGQ IQDYYRDSRV LHTDDDYCDA GNFSFSSSSS GGFPYECGDG GCDLSPGMKG GSLVMKRRRR LRSDAEMQQL RQAANVRERR RMQSINDAFE GLRSHIPTLP YEKRLSKVDT LRLAIGYINF LSEMVQSDLP LRNPNSDSGN QPKKVIICHR GTRSPSPSDP DYGLPPLAGH SLSWTDEKQL RDQNVVRTAK VWTPEDPRKL NKSPFSNIEN EPPLTLCLDM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Acts together with pdx1 to induce the pancreatic lineage within the endoderm. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
  • 基因功能参考文献：
    1. Our results demonstrate that Prdm13, downstream of Ptf1a, acts as an important regulator of glycinergic amacrine subtype specification in the Xenopus retina. We also reveal that Prdm13 regulates ptf1a expression through a negative feedback loop. PMID: 28863786
    2. Xenopus Ptf1a is essential for the initial specification of both endocrine and exocrine cells during normal pancreas development. PMID: 17320068
    3. Ptf1a overexpression leads to an increased ratio of GABAergic subtypes among the whole amacrine and horizontal cell population, highlighting its instructive capacity to promote this specific subtype of inhibitory neurons PMID: 17910758
    4. analysis of the gene regulatory network activated by Ptf1a in early pancreas development;results revealed that Ptf1a regulates genes with a wide variety of functions, providing insight into the complexity of the regulatory network required for pancreas specification PMID: 22815262
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: xla:100381084

    UniGene: Xl.29862