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  4. Recombinant E3 ubiquitin-protein ligase hrd-1 (sel-11)

Recombinant E3 ubiquitin-protein ligase hrd-1 (sel-11)

  • 中文名称：
    秀丽隐杆线虫sel-11重组蛋白
  • 货号：
    CSB-CF635313CXY
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    sel-11
  • Uniprot No.：
  • 别名：
    sel-11; hrd-1; F55A11.3; E3 ubiquitin-protein ligase hrd-1; RING-type E3 ubiquitin transferase hrd-1; Suppressor/enhancer of lin-12
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-610
  • 氨基酸序列
    FLINKQFYPSIVYLSKSNASMAVIYVQGIVLVYLMFQLLKSILFGDLRAAEAEHLSERTW HAVLETCLAFTVFRDDFSAIFVMQFIGLLFIKCFHWLADDRVDMMERSPVITLRFHLRMM TVLAALGFADSYFVSSAYFTTITRGASAQIVFGFEYAILLALVLHVTIKYLLHMHDLRNP QSWDNKAVYLLYAELFINLIRCLLYGFFAVVMLRVHTFPLFSVRPFYQSVRALHKAFLDV ILSRRAINAMNSQFPVVSAEDLAAMDATCIICREEMTVDASPKRLPCSHVFHAHCLRSWF QRQQTCPTCRTDIWQGRNGAAAGGNAADAAANVADANVAGAQIGAGMPPFLPFLGHQFGF PQQPAGAGGAQPGAAQAGGQPGPFPHQIFYAPAPANRPEFMNLIPPPPLPMAGPPGMFPM MPPPPLPQVNTTQGTSSETPPVNPSYSQLSTEELRRMEGESREALLARLQAMDNIMVLLE SAQMQMIQLATVTPIRPRPVVPSDESEQEAPGPSTDQVTSEEQEIPATSSAPSIFRTESP STSSTAPSTSSPVTASSTPTTSSTRTPEAEEVRQRRLARLLGENANQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Thought to play a role together with hsp-3 in developmental growth and function of intestinal cells and to play a role together with hsp-4 in gonad formation.
  • 基因功能参考文献：
    1. HRD-1 play essential roles in unfolded protein response (UPR) and ERAD pathways. We further found that HRD-1 functions in concert with BiP. PMID: 17825049
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    HRD1 family
  • 数据库链接：

    KEGG: cel:CELE_F55A11.3

    STRING: 6239.F55A11.3.1

    UniGene: Cel.23482