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  4. Recombinant Epstein-Barr virus Probable membrane protein (BILF1)

Recombinant Epstein-Barr virus Probable membrane protein (BILF1)

  • 中文名称：
    Recombinant Epstein-Barr virus Probable membrane protein (BILF1)
  • 货号：
    CSB-CF360988EFA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    BILF1
  • Uniprot No.：
  • 别名：
    BILF1; G-protein coupled receptor BILF1
  • 种属：
    Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-312
  • 氨基酸序列
    MLSTMAPGSTVGTLVANMTSVNATEDACTKSYSAFLSGMTSLLLVLLILLTLAGILFIIF VRKLVHRMDVWLIALLIELLLWVLGKMIQEFSSTGLCLLTQNMMFLGLMCSVWTHLGMAL EKTLALFSRTPKRTSHRNVCLYLMGVFCLVLLLIIILLITMGPDANLNRGPNMCREGPTK GMHTAVQGLKAGCYLLAAVLIVLLTVIIIWKLLRTKFGRKPRLICNVTFTGLICAFSWFM LSLPLLFLGEAGSLGFDCTESLVARYYPGPAACLALLLIILYAWSFSHFMDSLKNQVTVT ARYFRRVPSQST
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Constitutively active G protein-coupled receptor that plays a role in the modulation of host immunity. As a consequence of its constitutive activity, mediates host CXCR4 inhibition. Enhances degradation of host major histocompatibility complex class I antigens via lysosomes. Targets also newly synthesized MHC-I/peptide complexes en route to the host cell surface. Inhibits the host EIF2AK2/PKR phosphorylation.
  • 基因功能参考文献：
    1. These data indicate that whilst BNLF2a interferes with antigen presentation with diminishing efficiency as lytic cycle progresses (IE>E>>L), interference by BILF1 increases with progression through lytic cycle (IE PMID: 25144360
    2. BILF1 cytoplasmic C-terminal tail is required for reducing surface HLA class I expression since it is expressed early in the viral lytic cycle targeting a broad range of (HLA) class I molecules, including multiple HLA-A and -B types and HLA-E. PMID: 23315076
    3. This study therefore extends our initial observations on BILF1 to show that this immunoevasin can target MHC-I antigen presentation via both the exocytic and endocytic trafficking pathways. PMID: 21123379
    4. Study show the formation of hetero-oligomeric complexes between this viral BILF1 and human CXCR4. BILF1 impaired CXCL12 binding to CXCR4 and, consequently, also CXCL12-induced signaling. PMID: 20622011
    5. Inverse agonists for BIL1 could inhibit cell transformation and be relevant therapeutic candidate. PMID: 20543866
    6. BILF1 physically interacts with various host chemokine receptors on the cell surface of human cells. PMID: 18823943
    7. BILF1 reduced the levels of MHC class I at the cell surface and inhibited CD8(+) T cell recognition of endogenous target antigens PMID: 19119421

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  • 亚细胞定位：
    Host cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Epstein-Barr virus BILF1 protein family
  • 数据库链接：

    KEGG: vg:3783707