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  4. Recombinant Human Presqualene diphosphate phosphatase (PPAPDC2)

Recombinant Human Presqualene diphosphate phosphatase (PPAPDC2)

  • 中文名称：
    人PLPP6重组蛋白
  • 货号：
    CSB-CF809012HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    PLPP6
  • Uniprot No.：
  • 别名：
    PLPP6; PPAPDC2; Phospholipid phosphatase 6; Phosphatidic acid phosphatase type 2 domain-containing protein 2; PPAP2 domain-containing protein 2; Presqualene diphosphate phosphatase
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-295
  • 氨基酸序列
    MPSPRRSMEGRPLGVSASSSSSSPGSPAHGGGGGGSRFEFQSLLSSRATAVDPTCARLRA SESPVHRRGSFPLAAAGPSQSPAPPLPEEDRMDLNPSFLGIALRSLLAIDLWLSKKLGVC AGESSSWGSVRPLMKLLEISGHGIPWLLGTLYCLCRSDSWAGREVLMNLLFALLLDLLLV ALIKGLVRRRRPAHNQMDMFVTLSVDKYSFPSGHATRAALMSRFILNHLVLAIPLRVLVV LWAFVLGLSRVMLGRHNVTDVAFGFFLGYMQYSIVDYCWLSPHNAPVLFLLWSQR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.
  • 基因功能参考文献：
    1. Data indicate that polyisoprenyl diphosphate phosphatase 1 (PDP1) serves an integral signaling role in neutrophil proinflammatory responses and as a target for counter-regulatory mediators. PMID: 23568778
    2. PDP1 can serve as a new checkpoint for polyisoprenyl phosphate remodeling during cell activation.[PDP1] PMID: 19220020
    3. PDP1/PPAPDC2 is a functional isoprenoid diphosphate phosphatase. PMID: 20110354
    4. findings indicate that PPAPDC2 in human PMN is the first lipid phosphate phosphohydrolase identified for PSDP; regulation of this activity of the enzyme may have important roles for PMN activation in innate immunity PMID: 16464866
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    PA-phosphatase related phosphoesterase family
  • 组织特异性：
    Widely expressed. Expressed in most organs, in particular gastrointestinal organs, spleen, placenta, kidney, thymus and brain.
  • 数据库链接：

    HGNC: 23682

    OMIM: 611666

    KEGG: hsa:403313

    STRING: 9606.ENSP00000371307

    UniGene: Hs.107510