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  4. Recombinant Mouse C-C chemokine receptor type 6 (Ccr6)

Recombinant Mouse C-C chemokine receptor type 6 (Ccr6)

  • 中文名称：
    Recombinant Mouse C-C chemokine receptor type 6(Ccr6)
  • 货号：
    CSB-CF004845MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Ccr6; Cmkbr6; C-C chemokine receptor type 6; C-C CKR-6; CC-CKR-6; CCR-6; KY411; CD antigen CD196
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-367
  • 氨基酸序列
    MNSTESYFGTDDYDNTEYYSIPPDHGPCSLEEVRNFTKVFVPIAYSLICVFGLLGNIMVV MTFAFYKKARSMTDVYLLNMAITDILFVLTLPFWAVTHATNTWVFSDALCKLMKGTYAVN FNCGMLLLACISMDRYIAIVQATKSFRVRSRTLTHSKVICVAVWFISIIISSPTFIFNKK YELQDRDVCEPRYRSVSEPITWKLLGMGLELFFGFFTPLLFMVFCYLFIIKTLVQAQNSK RHRAIRVVIAVVLVFLACQIPHNMVLLVTAVNTGKVGRSCSTEKVLAYTRNVAEVLAFLH CCLNPVLYAFIGQKFRNYFMKIMKDVWCMRRKNKMPGFLCARVYSESYISRQTSETVEND NASSFTM
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity. Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma. CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells. Positively regulates sperm motility and chemotaxis via its binding to CCL20.
  • 基因功能参考文献：
    1. gammadeltaT17 cells constitutively express chemokine receptors CCR6 and CCR2 PMID: 28580944
    2. Obesity-induced IL-6 shifts macrophage polarization towards tumor-promoting macrophages that produce the CCL-20 in the colitis-associated colorectal cancer (CAC) microenvironment. CCL-20 promotes CAC progression by recruiting CCR6-expressing B-cells and gammadelta T cells via chemotaxis. PMID: 29695802
    3. CCR6 facilitates tumor angiogenesis via the AKT/NF-kappaB/VEGF pathway in colorectal cancer PMID: 29097259
    4. CCR6 defines memory B cell precursors in mouse and human germinal centers, revealing light-zone location and predominant low antigen affinity. PMID: 29262350
    5. Study identified protein and gene expression of chemokine receptor 6 in the hippocampus of Swiss mice with immunohistochemistry and RT-PCR, showed that CCR6 may be involved in normal neuronal activity in the hippocampus and play an important role in maintenance of the status epilepticus. PMID: 27423018
    6. these data indicate that CCL20/CCR6 signaling may play an important role in regulating bone mass accrual, potentially by modulating osteoblast maturation, survival, and the recruitment of osteoblast-supporting cells. PMID: 26890063
    7. CCR6 is upregulated rapidly within hours on the protein or mRNA level after activation in vitro. PMID: 27465674
    8. These findings identify a crucial role for CCR6 in promoting LP-mononuclear phagocytes to associate with the intestinal epithelium in the steady state to perform multiple functions promoting gut immune homeostasis. PMID: 28746740
    9. data suggest that gammadeltaT17 cells are completely dependent on CCR6 for homing to psoriasiform skin. Thus, CCR6 may constitute a novel target for a mechanistically distinct therapeutic approach to treating psoriasis. PMID: 28972090
    10. Data (including data from studies using knockout mice or cells from knockout mice) suggest that HuR post-transcriptionally regulates Ccr6 expression by binding to and stabilizing Ccr6 mRNA and by promoting Ccr6 translation in helper T-cells; knock-out of HuR reduces Ccr6 expression on helper T-cells, impairs their migration to CNS, and prevents experimental autoimmune encephalomyelitis. (HuR = Hu antigen R) PMID: 28684423
    11. CCR6 deficiency affects hepatic inflammatory cell recruitment resulting in the promotion of hepatic inflammation and fibrosis. PMID: 26691857
    12. in mice, activated B cells use the chemokine receptor CCR6 to access the subepithelial dome (SED) of Peyer's patches. PMID: 27174992
    13. CCR6 might be crucial for optimal development of Th2 immune responses. PMID: 26307432
    14. This study delineated for the first time a role for CCR6 in the development of breast cancer. PMID: 26047945
    15. results suggest a key role for CD28 costimulation in promoting a central Treg to eTreg transition with appropriate upregulation of chemokine receptors such as CCR6 that are required for tissue homing PMID: 26408668
    16. CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen. PMID: 25505290
    17. these data indicate that CCR6 has a supplementary role in coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for normal nTreg development. PMID: 24638065
    18. CCR6 deficieny leads to a diminished cerebral immune response in experimental pneumococcal meningitis. PMID: 24699535
    19. The results of this study suggest that ccr6 may play a role in cognition and learning behaviour, as well as anxiety and other behaviours. PMID: 24333375
    20. regulates recruitment of monocytes and macrophages to the inflamed vessel promoting atherosclerosis PMID: 24114205
    21. Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease. PMID: 24223818
    22. Chemokine receptor CCR6-dependent accumulation of gammadelta T cells in injured liver restricts hepatic inflammation and fibrosis. PMID: 23959575
    23. Data indicate that a CCR6/CCL20 chemokine loop instructed rapid increase of B cells in the spleen in response to systemic administration of Nod1 agonists in a TNF-alpha-dependent manner. PMID: 24534531
    24. gene knock-out results in increased number of germinal centers and their faster generation PMID: 23588497
    25. Mice deficient in expression of the chemokine receptors CCR2 or CCR6 were resistant to infection with Trichuris. PMID: 23555902
    26. CXCR3 promotes recruitment of Th17 cells from the blood into the liver in both human and murine liver injury. Their subsequent positioning near bile ducts is dependent on CCR6 and cholangiocyte-secreted CCL20. PMID: 22796894
    27. CCR6-deficient mice develop less severe experimental encephalitis and present a repressed recall response in the induction phase. PMID: 23477966
    28. Programmed downregulation of CCR6 is important for establishment of epidermal gammadeltaT cells by regulating their thymic egress and epidermal location. PMID: 23420888
    29. these data show that CCR6 regulates epidermal trafficking of gammadelta-T-cell subsets in the skin and suggest the potential of CCR6 as a therapeutic target for psoriasis. PMID: 22895364
    30. Analysis of tumor-infiltrating leukocytes reveals a significant increase of CCR6-positive B220-positive lymphocytes in solid tumors derived from beta-defensin 14-overexpressing tumor cells. PMID: 22504651
    31. In an IL-23 skin injection model of psoriasiform dermatitis, interleukin (IL)-22, IL-17A, and IL-23 receptor are highly enriched in a population of CCR6+ T cell receptor gammadelta-low expressing T cell keratinocytes that accumulate in the epidermis. PMID: 21984702
    32. plasmacytoid dendritic cells are recruited to imiquimod-treated skin tumors in WT but not CCR6-deficient mice, and competitive adoptive transfers reveal that CCR6-deficient pDCs are impaired in homing to inflamed skin tumors after intravenous transfer PMID: 21937703
    33. Tumor-associated macrophages recruit CCR6+ regulatory T cells and promote the development of colorectal cancer via enhancing CCL20 production in mice PMID: 21559338
    34. Ccr6 promotes atherosclerosis in ApoE-deficient mice, which may be due in part to Ccr6 support of normal monocyte levels in blood, as well as direct Ccr6-dependent monocyte migration. PMID: 21680896
    35. Plasmin had an essential role in the recruitment and activation of pathogenic C-C chemokine receptor type 6 (CCR6)+ T cells. PMID: 21311769
    36. gene deficiency causes remarkable decrement of M cells responsible for uptake of mucosal antigens in Peyer's patches PMID: 21422150
    37. correspond to a discrete innate lymphoid cell population expressing CD25, CCR6 and IL-7R PMID: 21400499
    38. CCR6 is required for iNKT cells recrutiment and innate immunity mycobacterial clearance from lungs. PMID: 21042003
    39. Ccr6-deficient naive T cells induce more severe colitis, compared with wild-type T cells, following adoptive transfer to Rag2-deficient hosts. PMID: 20720211
    40. CCR6 seems to have an important role for lin(-) c-kit(+) cells inside CP PMID: 20148914
    41. beta-defensin 4 and 14 are chemotactic for a broad spectrum of leukocytes in a CCR6- and CCR2-dependent manner. PMID: 20483750
    42. CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis. PMID: 20299360
    43. The expression pattern of CCR6 on subsets of DC & T cells during respiratory syncytial virus infections showed an increase on CD69+ T8 cells but not on CD69+ T4 cells. CCR6-/- mice had reduced lung pathology & more efficient viral clearance. PMID: 20101616
    44. Data show that recombinant mBD4:Ig and hBD2:Ig fusion proteins retained potent antimicrobial activity against Gram-negative and Gram-positive bacteria, and that these fusion proteins showed specific binding to CCR6-expressing cells. PMID: 20068036
    45. These studies highlight a mast cell- and immunoglobulin E-independent role for CCR6-bearing T cells in the pathogenesis of gastrointestinal allergic disease PMID: 19782082
    46. CCR6 is present on lymphocyte precursors in intestinal cryptopatches, expressed transiently during extrathymic intraeptihelial T lymphocyte (IEL) development, and is required for homeostatic regulation of intestinal IEL. PMID: 12928364
    47. CCR6 has multiple domains involved in ligand binding and receptor signaling PMID: 15591779
    48. expression of CCR6 fully cosegregates with CD45RO, an established marker of human memory T cells. PMID: 15613550
    49. The defect in CCR6-deficient mice appears to be primarily due to an alteration in T cell activation, but also appears to include local pulmonary antigen-presenting cell defects. PMID: 15699135
    50. role for CCR6 in recruiting alloreactive CD4+ T cells to target tissues in graft-versus-host disease PMID: 15774622

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell surface.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Sperm. Mainly localized in the principal piece and neck region of the tail but is also found in the acrosomal region in a small percentage of sperm cells. Expressed in natural regulatory T cells (nTregs) and a subset of early thymocyte progenitor double-n
  • 数据库链接：

    KEGG: mmu:12458

    STRING: 10090.ENSMUSP00000095029

    UniGene: Mm.8007