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  4. Recombinant Mouse Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a)

Recombinant Mouse Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a)

  • 中文名称：
    小鼠Tnfrsf1a重组蛋白
  • 货号：
    CSB-CF023977MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Tnfrsf1a; Tnfr-1; Tnfr1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD antigen CD120a
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    30-454
  • 氨基酸序列
    LVPSLGDREKRDSLCPQGKYVHSKNNSICCTKCHKGTYLVSDCPSPGRDTVCRECEKGTFTASQNYLRQCLSCKTCRKEMSQVEISPCQADKDTVCGCKENQFQRYLSETHFQCVDCSPCFNGTVTIPCKETQNTVCNCHAGFFLRESECVPCSHCKKNEECMKLCLPPPLANVTNPQDSGTAVLLPLVILLGLCLLSFIFISLMCRYPRWRPEVYSIICRDPVPVKEEKAGKPLTPAPSPAFSPTSGFNPTLGFSTPGFSSPVSSTPISPIFGPSNWHFMPPVSEVVPTQGADPLLYESLCSVPAPTSVQKWEDSAHPQRPDNADLAILYAVVDGVPPARWKEFMRFMGLSEHEIERLEMQNGRCLREAQYSMLEAWRRRTPRHEDTLEVVGLVLSKMNLAGCLENILEALRNPAPSSTTRLPR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
  • 基因功能参考文献：
    1. This study demonstrated that the TNFR1, but not TNFR2, is Required for Both Histaminergic and Non-histaminergic Itch in Mice. PMID: 28365861
    2. p55TNFR shedding has a prominent role in Th1 mediated protection against chronic and latent tuberculosis infection PMID: 27995986
    3. p55TNFR-IKK2-Ripk3 signalling orchestrates arthritogenic and death responses in synovial fibroblasts PMID: 29434332
    4. his study shows that CCR-2/TLR-2 triggered signaling in murine peritoneal macrophages intensifies bacterial (Staphylococcus aureus) killing by reactive oxygen species through TNF-R1 PMID: 28736159
    5. Results provide experimental data on the existence of a TNFRp55-mediated anti-inflammatory circuit in dendritic cells which might contribute to the protection against reactive arthritis during the resolution of Yersinia entercolitica infection. PMID: 29494692
    6. TNFR1 contributes to ethanol-induced hypertension and oxidative stress in the vasculature. PMID: 28797835
    7. TNFR2 is important for the proliferative expansion of pathogenic Teff cells PMID: 27601345
    8. NEMO deficiency hampered activation of IKK complex in osteoclast precursors, causing arrest of osteoclastogenesis and apoptosis. Interestingly, inhibiting apoptosis by genetic ablation of TNFr1 significantly increased cell survival, but failed to rescue osteoclastogenesis or reverse osteopetrosis. PMID: 27435916
    9. Data indicate that IL-1RI and TNF-1R contribute to regulation of stress-induced, negatively reinforced drinking perhaps through overlapping signaling events downstream of these receptors, while leaving rewarding properties of alcohol largely unaffected. PMID: 27273552
    10. Myeloid-derived suppressor cells from tumor necrosis factor receptor (TNFR) 2(-/-) mice, but not from TNFR1(-/-) mice, failed to promote B-cell responses. PMID: 27133471
    11. TNFR2 is required for inflammation-inducible M cells. PMID: 27932454
    12. These findings indicate that TNFR1 is structurally positioned to modulate postsynaptic signaling in the PVN, suggesting a mechanism whereby TNFR1 activation contributes to cardiovascular and other autonomic functions. PMID: 28385632
    13. Increased TNFR1 expression and signaling in injured peripheral nerves of mice with reduced BACE1 activity PMID: 27080468
    14. Genetic deletion of TNFR1 completely blocks TNF-alpha-induced inflammation and reduces allergen-induced inflammation. Preserved electro-olfactogram responses suggest a TNFR1-dependent mechanism of TNF-alpha-induced olfactory neuron dysfunction. PMID: 27671548
    15. This work uncovers a dichotomy of function for TNFR2 in myeloid cells, with microglial TNFR2 providing protective signals to contain disease and monocyte/macrophagic TNFR2 driving immune activation and experimental autoimmune encephalomyelitis initiation. PMID: 28052249
    16. The deficiency of TNFRp55 promoted the development of endometriosis. PMID: 28676525
    17. TNFalpha enhanced murine NK cell IFNgamma production via TNFR2 in vitro PMID: 27560480
    18. TNFR2 sensitizes macrophages for endogenous TNF-induced TNFR1-mediated necroptosis PMID: 27899821
    19. this study shows that epithelial TNFR1 signaling promotes mucosal repair in inflammatory bowel disease PMID: 28747340
    20. HACE1 controls TNF-elicited cell fate decisions and exerts tumor suppressor and anti-inflammatory activities via a TNFR1-RIP3 kinase-necroptosis pathway. PMID: 27160902
    21. TNFR2 activation exerted beneficial effects on OPA1 expression in an aortic constriction model. PMID: 28637784
    22. Following activation by transmembrane TNF, TNFR2 initiates pathways that drive oligodendrocytes into a reparative mode contributing to remyelination following disease PMID: 27147664
    23. The apoptotic signals through TNFR1 appear critical for the pathogenesis of pulmonary emphysema. PMID: 27555760
    24. TNFR1 signaling in myeloid-derived cells is a critical mediator of both the detrimental and the protective functions of TNF in T cell-induced hepatitis and bacterial infection, respectively. PMID: 26991125
    25. Suggest an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFalpha and TNFR2, thereby preventing overactivation of endogenous TNFR2 signaling in cells of the vasculature. PMID: 28062509
    26. this study shows that Tnfr1 knock-out display reduced chemotaxis of myeloid-derived suppressor cells to tumor, and mice reject transplanted tumor PMID: 28092866
    27. tumor necrosis factor-alpha, through its receptor tumor necrosis factor receptor -1, promoted cell proliferation and cell survival in prostate by activation of the AKT/mTOR and NFKB pathway, which stimulated prostate carcinogenesis PMID: 27018768
    28. Report chronic inflammatory multiorgan hepatobiliary pancreatitis, along with fibrosis and calculi formation induced by oral dibutyltin administration in TNFR1/R2 deficient mice. PMID: 27275091
    29. Knockdown of TNFR1 not only inhibited the JNK pathway but also reduced Toll-like receptor 2 protein and RANKL levels in S. aureus-infected cells. PMID: 26846887
    30. we have demonstrated that PGRN-mediated inhibition of chemokine expression largely depends on TNFR1. PMID: 26892362
    31. The results of comparative analysis of interaction between the protein cytotoxic complex Tag 7-Hsp70 and the Tag 7 component of this complex with TNFR1 receptor in solution and in tumor cells are presented. PMID: 27021371
    32. These results show that in the absence of TNFRp55, Leishmania (Leishmania) amazonensis-infected knockout mice fail to resolve lesions, whereas wild-type mice completely heal. PMID: 24856420
    33. These findings implicate TNF-receptor signaling cascades in the regulation of homeostatic plasticity of denervated networks and suggest an important role for TNFalpha-signaling in the course of neurological diseases accompanied by deafferentation. PMID: 26246237
    34. DMS5540 is a potent mouse TNFR1 antagonist with in vivo pharmacokinetic PMID: 26352810
    35. TNF receptor 1 (TnfR1) signaling is believed to be a major mediator of the cytotoxicity of Tnf-a through activation of caspases. PMID: 26189092
    36. The s found that miR-511 inhibits endotoxemia and experimental hepatitis and that this miR is strongly induced by glucocorticoids and is a true TNFR1 modulator and thus an anti-inflammatory miR. PMID: 25995337
    37. Data show that ileal sections were costained for glucagon-like peptide-1 (GLP-1) and tumor necrosis factor receptor TNFR1. PMID: 26270730
    38. quercetin reduces cell survival and promotes death receptor-mediated apoptosis via differential localization of the TNFR1 level in ascite cells PMID: 26076811
    39. Following memory deficit induced by sepsis, memory is preserved in the absence of TNFR1. PMID: 25148914
    40. we identified P55-induced goblet and Paneth cell dysfunction as a crucial mechanism for TNF-induced systemic and lethal inflammation. PMID: 25425265
    41. In IL-32alpha-Tg mice, azoxymethane (AOM)-induced colon cancer incidence was decreased, whereas expression of TNFR1 and TNFR1-mediated apoptosis was increased. PMID: 25909160
    42. pan antagonist of AnxA1 receptors exacerbated the colitis outcome in TNFR1-/- mice, supporting the pivotal role of AnxA1 in the early recovery PMID: 26386311
    43. Data show that the in utero death of NF-NF-kappaB essential modulator (NEMO) and cylindromatosis protein double mutant mice is mediated by TNF receptor 1 (TNFR1) signaling and can be rescued by TNFR1 deficiency. PMID: 26224629
    44. TNFR2 promotes generation of Foxp3+ Tregs. TNFR2 inhibits Th17 differentiation by promoting Il2 expression. And under Th17-polarizing conditions, selective blockade of CD4(+) T cell-intrinsic TNFR2 appears sufficient to promote Th17 differentiation. PMID: 26268655
    45. TNFR1 (and JNK signaling) is the shared pathway leading to neuroinflammation and neurovascular damage. PMID: 25540015
    46. PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner. PMID: 25387791
    47. results suggest that the ability of S. aureus to activate TNFR1 and Ca(2+)/calpain signaling contribute to T cell activation and excessive inflammation in the setting of acute pneumonia. PMID: 24736233
    48. necroptosis induced by various ER stressors in L929 cells is dependent on tumor necrosis factor receptor 1. PMID: 25569104
    49. Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling. PMID: 25628461
    50. TNFR1- and IFNAR1-deficient mice showed partial protection toward Aldara-induced inflammation compared with control groups. Double knockout mice lacking both receptors showed superior protection to Aldara in comparison with the single knockout mice. PMID: 25911755

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein.
  • 数据库链接：

    KEGG: mmu:21937

    STRING: 10090.ENSMUSP00000032491

    UniGene: Mm.1258