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  4. Recombinant Rat CD44 antigen (Cd44)

Recombinant Rat CD44 antigen (Cd44)

  • 货号：
    CSB-CF004938RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Cd44; CD44 antigen; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD antigen CD44
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-503
  • 氨基酸序列
    QQQIDLNITCRYAGVFHVEKNGRYSISRTEAADLCEAFNTTLPTMAQMELALRKGFETCRYGFIEGHVVIPRIHPNAICAANNTGVYILLASNTSHYDTYCFNASAPLEEDCTSVTDLPNSFDGPVTITIVNRDGTRYSKKGEYRTHQEDIDASNIIDEDVSSGSTIEKSTPEGYILHTDLPTSQPTGDRDDAFFIGSTLATIATTPWVSAHTKQNQERTQWNPIHSNPEVLLQTTTRMTDIDRNSTSAHGENWTQEPQPPFNNHEYQDEEETPHATSTTWADPNSTTEEAATQKEKWFENEWQGKNPPTPSEDSHVTEGTTASAHNNHPSQRMTTQSQEDVSWTDFFDPISHPMGQGHQTESKGHSSGNQDSGVTTTSGPARRPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGTVEDRKPSELNGEASKSQEMVHLVNKEPTETPDQFMTADETRNLQSVDMKIGV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion.
  • 基因功能参考文献：
    1. The findings indicate for the first time that regulation of Rac1 activity is responsible for hyaluronidase and CD44-driven morphological changes of astrocytes. PMID: 27163367
    2. results suggest that the AT1 receptor is involved in development of hypertension and cardiac fibrosis. Selective activating ACE2/eNOS and inhibiting CD44/HA interaction might be considered as the therapeutic targets for attenuating Ang II induced deleterious cardiovascular effects PMID: 27085217
    3. Results define a clinically relevant role for signaling by the hyaluronan receptor, CD44, in increased responsiveness to mechanical stimulation PMID: 26996509
    4. Peptide inhibitors of CD44v6 isoforms block tumor growth and metastasis in several independent models of pancreatic cancer. PMID: 26597578
    5. Expression of CD44 followed the same temporal pattern as hyaluronic acid deposition in a bladder regeneration model. PMID: 25253654
    6. Results indicate a novel role for CD44 as an essential regulator of dendritic arbor complexity in both health and disease. PMID: 25300795
    7. Data show that hyaluronan receptor CD44 undergoes co-internalization with hyaluronan endocytosis. PMID: 25733665
    8. release of the CD44 intracellular domain into the cytoplasm of cells such as chondrocytes exerts a competitive or dominant-negative effect on the function of full-length CD44. PMID: 23884413
    9. CD44 is a key molecule in the migration of OPCs toward the focal inflammatory demyelinated lesion induced by zymosan PMID: 23280959
    10. after experimental TBI, hippocampal neurons grew well on an OPN substrate with growth comparable to that seen on laminin, but showed a higher degree of primary neurites; growth on OPN was mediated through beta1 intregrins and CD44. T PMID: 22692550
    11. Upregulation of hyaluronan and its binding receptors CD44 and LYVE-1 are involved in interstitial fibrosis in chronic cyclosporine-induced renal injury. PMID: 20470282
    12. Results describe how CD44 regulates the motility and invasive growth of B35 neuroblastoma cells into a hyaluronan-rich environment. PMID: 20056122
    13. Data show that Hyal2, through direct interactions with CD44 and possibly some pericellular hyaluronidase activity suppresses the formation or the stability of the glycocalyx, modulates ERM-related cytoskeletal interactions, and diminishes cell motility. PMID: 19783662
    14. Data show that neither CD44v nor exosomes alone suffice for (pre)metastatic niche formation. PMID: 19794968
    15. role of colocalization with osteopontin in migration, cell fusion, and resorption in osteoclasts PMID: 12162503
    16. Data show that CD44 antigen is upregulated on all migrating cells and on newly formed blood vessels at the onset of the foreign body reaction. PMID: 12579564
    17. Microarray analysis and RNA silencing link fra-1 to the expression of this antigen and c-met expresssion in mesothelioma. PMID: 12839939
    18. Cd44 variant isoforms associate with tetraspanins and EpCAM. PMID: 15212938
    19. Cd44 expression identifies astrocyte-restricted precursor cells. PMID: 15531362
    20. The helper and cytotoxic subsets of T cells, as well as B cells, display the increased expression of CD44, intercellular adhesion molecule 1 and lymphocyte function associated antigen 1 PMID: 15624701
    21. migration of rat hepatic stellate cells requires hyaluronic acid and CD44v6 PMID: 15691832
    22. NCoR, GAF, and TR interact with the CD44 negative T(3)-responsive element to enhance basal transactivation, whereas T(3) induces the remodeling of chromatin structure for repression PMID: 15701601
    23. role of CD44-hyaluronan interaction in mesenchymal stem cell migration in the extracellular matrix PMID: 16306150
    24. CD44 is a specific marker of small hepatocytes. PMID: 16580085
    25. CD44 is probably involved in early leukocyte infiltration, in tubular regeneration, and in macrophage activity in the rat kidney after ischemia/reperfusion injury. PMID: 16786159
    26. The expression pattern of CD44 was studied in the rat testis following ischemia/reperfusion (I/R) injury to elucidate the possible role of the CD44 adhesion molecule in acute experimental testicular torsion. PMID: 16891795
    27. The association of ezrin, radixin and moesin proteins to the coreceptor is absolutely required to mediate the hepatocyte growth factor-dependent activation of Ras by the guanine nucleotide exchange factor Sos. PMID: 17065554
    28. CD44 has a pivotal role in the trans-endothelial migration of NPCs across brain endothelial cells PMID: 18450824
    29. CD44-hyaluronan interaction, by enhancing biliary proliferation, may play a pathogenic role in the development of cholestatic liver diseases. PMID: 18556418
    30. Data show that the rapid and transient induction of CD44 occurrs in activated microglia/macrophages following transient forebrain ischemia. PMID: 18638458
    31. CD44 upregulation in neurons is affected by local chondroitin sulfate proteoglycan expression. PMID: 18694596
    32. CD44 variant isoforms promote metastasis formation by a tumor cell-matrix cross-talk that supports adhesion and apoptosis resistance. PMID: 19208744
    33. CD44 may play an important role in the development of airway inflammatory in asthma. PMID: 19222954
    34. Importantly, TSC activation upon ALS-like neurodegeneration results in significant increase in molecular proximity of CD44 and ErbB3, which may have an impact on glial plasticity at the NMJ. PMID: 19385056
    35. Results suggest that Tra2beta may regulate cellular oxidative response by changing alternative splicing of distinct genes including CD44. PMID: 19439532

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection, microvillus.
  • 数据库链接：

    UniGene: Rn.1120