Recombinant Rat Corticotropin-releasing factor receptor 1 (Crhr1)

1. Irritability-like behavior following abstinence from ethanol exposure is partially mediated by activation of the CRF1 receptor. PMID: 28833238
2. CRHR1 blockade using Antalarmin (ANT) improved behavioral impairments, while conferring neuroprotection and blunting neuroinflammation in all hippocampal sub-regions post ischemia. Also observed reduced BDNF and TrkB mRNA and protein levels at the hippocampus, and increased expression at the hypothalamus and amygdala post ischemia, site-specific alterations which were regularized by pre-ischemic CRHR1 blockade. PMID: 28647536
3. These results indicate that the central CRF signal, rather than the peripheral CRF signal would be related to anxiety and other behavioral changes, and CRF1 receptor antagonism in the central nervous system may be critical for identifying drug candidates for anxiety and mood disorders PMID: 28689880
4. Study found that bilateral microinjection of selective CRF1 receptor antagonist CP376395 into the bed nucleus of stria terminalis (BNST) decreased the bradycardiac response to arterial pressure increase without affecting the baroreflex tachycardiac response; CRF2 receptor antagonist antisauvagine-30 microinjection reduced the tachycardiac response to arterial pressure decrease without affecting the reflex bradycardia. PMID: 28612996
5. the involvement of the HPA axis in traumainduced anxiety was demonstrated, and trauma-induced anxiety was attenuated by decreasing the hyperactivity of the HPA axis via miR34b by targeting CRHR1. PMID: 28498394
6. Results suggest that corticotrophin-releasing factor type 1 receptor (CRF1) is involved in the modulation of the functions of the pituitary; moreover, protein expression and the distribution patterns of CRF1 are regulated by glucocorticoids in the rat anterior pituitary. PMID: 27801962
7. These results revealed a prominent role for CRF1 signaling in mast cells as a positive modulator of stimuli-induced degranulation. PMID: 28684600
8. age-related alterations in acute central anorexigenic and hypermetabolic effects of CRF show different non-parallel patterns in males and females. Our findings underline the importance of gender differences. They also call the attention to the differential age-related changes in the CRF1 and CRF2 receptor systems PMID: 27637621
9. switch in G protein coupling for type 1 corticotropin-releasing factor receptors promotes excitability in epileptic brains PMID: 27303056
10. Study identified the activation of CRFR1 in the basolateral amygdala as a key mechanism interfering with the effectiveness of immediate fear extinction training. PMID: 27844053
11. The findings demonstrate that the long-term effect of acute stress on the expression of cocaine locomotor sensitization is partially mediated by CRFR1 in the ventromedial caudate putamen. PMID: 28431969
12. Chronic noise significantly accelerated the progressive overproduction of corticosterone and upregulated CRF and CRFR1 mRNA and protein, both of which persisted 7-14days after noise exposure. PMID: 27538655
13. maternal care is impaired by Bed Nucleus Stria Terminalis CRF-R1 activation, and this appears to be the result of a central action, rather than an effect of elevated circulating levels of CORT. PMID: 26630389
14. Exposure to acute traumatic stress in early adolescent can cause permanent changes in neural network, resulting in dysregulation of corticotrophin releasing factor expression, miR-34c expression in hypothalamus, anxiety-like behavior, and memory impairment, suggesting that the miR-34c expression in hypothalamus may be an important factor involved in post traumatic stress syndrome. PMID: 26925271
15. Study demonstrates sex differences in CRF receptor 1 and 2 mRNA changes within unique subnuclei of the dorsal raphe nucleus and the posterior ventral tegmental area PMID: 26696011
16. Competing roles of CRHR1 and CRHR2 on stress-induced in vivo serotonin synthesis. PMID: 26454419
17. CRF1 receptor levels did not differ significantly between genotypes but receptor blockade normalized both cue- and contextual fear in SERT(-/-) during acquisition, but not expression of fear-potentiated startle PMID: 26302762
18. Both acute and chronic noise increased CRH-R1 mRNA in the hypothalamus but decreased it in the hippocampus. PMID: 26333123
19. Study revealed that the alteration of central CRFR1 expression might play an important role in etiology of post-traumatic stress disorder in adulthood PMID: 25882722
20. Findings suggest that an early potentiation of CRF signaling at CRFR1 occurs following opioid exposure that begins to drive both opioid-induced hyperalgesia and eventually intake escalation. PMID: 24330252
21. The point mutations occurring in the CRF1-R gene of msP rats do not seem to influence basal anxiety while they appear to affect active responses to stress. PMID: 25260340
22. Activation of CRF1 receptors is required for the emergence of nicotine abstinence-induced anxiety-like behavior, hyperalgesia and excessive nicotine intake. PMID: 23869743
23. the increase in CRHR1 expression in the hypothalamus of stressed rats correlates with a decrease in the repressive chromatin state caused by reduced H3K9 trimethylation levels. PMID: 24867333
24. Neuromodulatory effects of interleukin-6 (IL-6) and corticotropin-releasing factor receptor (CRFR) 1 in visceral pain and stress-induced defecation in the WKY rat model of irritable bowel syndrome were investigated. PMID: 25260633
25. results indicate that CRF1 receptors in the dPAG play a pervasive role in the regulation of defensive responses associated with both generalized anxiety and panic. Recruitment of CRF2 receptors only impacts upon the former type of behaviors. PMID: 25146701
26. impaired miR449a expression causes dysregulation of Crhr1 expression in the anterior pituitary, resulting in prolonged HPA axis activation in restrained Low birth weight offspring. PMID: 25480379
27. Our results implicate CRHR1 and CRHR2 in coordinating the regulation of CRH neuronal activity in stress and behavioral responses. PMID: 25275258
28. We present evidence demonstrating prenatal hypoxia exposure induced anxiety-like behavior in adult male rat offspring and CRHR1 in paraventricular nucleus of the hypothalamus is involved. PMID: 25433848
29. The analgesic effect can be mediated by both CRF1 and CRF2 receptors. CRF-1 receptor, in contrast to the CRF2 receptors, may be involved in the regulation of the basal level of pain sensitivity. PMID: 25665407
30. Water-avoidance stress may activate peripheral CRF1 but not CRF2 signaling and stimulates gastric contractions without altering gastric emptying PMID: 23645119
31. results suggest that post-stress alcohol drinking may be driven by a high-nociception high-arousal state, and that brain CRF1R signaling mediates these stress effects. PMID: 24269607
32. This study demonistrated that crhr1 links peripuberty stress with deficits in social and stress-coping behaviors in rats model. PMID: 24630468
33. findings demonstrate that stress affects CRF1 expression in brain but also in ova, pointing to a possible mechanism of transgenerational transmission. PMID: 23726318
34. Data show that corticotropin releasing factor receptor 1 (CRF1) antagonists, NGD 98-2 and NGD 9002 prevented icv CRF-induced colonic secretomotor stimulation and blocked the induction of visceral sensitization. PMID: 24040053
35. Gestational intermittent hypoxia elicited a sex-dependent anxiety-like behavior in male offspring and activation of corticotropin-releasing hormone and CRH type-1 receptor mRNA in the hypothalamic paraventricular nucleus and in male hypothalamus. PMID: 23529784
36. MiR-449a plays an important role in stress-induced, glucocorticoid-mediated downregulation of CRF-R1 expression. PMID: 23893957
37. The CRHR1-triggered ERK 1/2 pathway is involved in the activation of p53 in rat hepatic cells. PMID: 23538210
38. The results of this study suggested that differences in monoaminergic neurotransmission and CRFR1 expression are associated with the coping strategy adopted by the animal and with the tendency to develop depression-related behaviors. PMID: 23732652
39. Peripheral CRF stimulates gastric contractions through CRF(1). PMID: 23205497
40. CRFR1 signaling plays a role in the anxiogenic effects of calcitonin gene-related peptide (CGRP) within the bed nucleus of stria terminalis. PMID: 23376701
41. Non-pain-related activation of CRF1 receptors in the amygdala can trigger pain-responses in normal animals. PMID: 23410057
42. These findings clearly demonstrate a gender-selective effect of gestational intermittent hypoxia to increase anxiety-like behavior and this anxiogenic effect might be linked to embryogenically-driven upregulation of PVN CRHR1. PMID: 23164543
43. CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis PMID: 23133512
44. Corticotropin-releasing factor receptor binding in the amygdala changes across puberty in a sex-specific manner PMID: 23117932
45. CRHR1 does not have a role in basal alcohol intake or relapse-like drinking situations with a low stress load. PMID: 22113086
46. During adolescence, nicotine reward is enhanced by recent stressor exposure in a manner that involves signaling at CRF-R1. PMID: 21720754
47. Data suggest that corticotropin releasing hormone (CRH) regulates dendritic outgrowth in cultured hippocampal neurons/pyramidal cells; signaling via CRH-R1 stimulates dendritic growth; CRH-R2 activation results in inhibition of dendritic growth. PMID: 22249942
48. The corticotropin-releasing factor CRF(1) receptor antagonist R278995/CRA0450 is centrally active under standard conditions as it inhibits REM sleep and promotes wakefulness. PMID: 22314225
49. Intracerebroventricular corticotropin-releasing factor and restraint increased both Fos-positive CRF and non-CRF neurons in the parvocellular paraventricular nucleus of the hypothalamus through activation of CRF1 and/or CRF2. PMID: 21964377
50. The non-competitive antagonist behaviour appeared to be correlated to the CRF(1) receptor off-rate kinetics. PMID: 21449919

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KEGG: rno:58959

STRING: 10116.ENSRNOP00000006764

UniGene: Rn.10499