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  4. Recombinant Rat Potassium voltage-gated channel subfamily D member 3 (Kcnd3)

Recombinant Rat Potassium voltage-gated channel subfamily D member 3 (Kcnd3)

  • 中文名称：
    大鼠Kcnd3重组蛋白
  • 货号：
    CSB-CF720324RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Kcnd3
  • Uniprot No.：
  • 别名：
    Kcnd3; Potassium voltage-gated channel subfamily D member 3; Voltage-gated potassium channel subunit Kv4.3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-655
  • 氨基酸序列
    MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLER YPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAF YGILPEIIGDCCYEEYKDRKRENAERLMDDNESENNQESMPSLSFRQTMWRAFENPHTST LALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVE YLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKF SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWY TIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRR AQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLL HCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHS GLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDG LRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSITSNVVKVSVL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
  • 基因功能参考文献：
    1. down-regulation of Kv4.3 channels mediating A-type K(+) (IA) currents currents in nociceptive V2 trigeminal neurons is an underlying mechanism of oxaliplatin-induced orofacial neuropathic pain. PMID: 29313436
    2. This study demonstated that that Kv4.3 is involved in vibration-induced muscle pain and explored whether changes in Kv4.3 expression in nociceptors contributes to the mechanical hyperalgesia in a model of hand-arm vibration syndrome in the rat. PMID: 26721612
    3. These results indicate that Kv4.3 is likely the target of discrepin and highlight the importance of the basic residue K13, located in the alpha-helix of the toxin, for current blockage. PMID: 24845726
    4. This study demonistrared that the expression and function of Kv4.3 channels in neurons of the rat bed nucleus of the stria terminalis. PMID: 24037673
    5. cardiomyocyte endosomes control channel kv4.3 mRNA expression by mediating delayed oxidative CamKII-p38K signaling. PMID: 22266351
    6. Immunocytochemistry indicated that protein expression for Kv4.3 increased between 1 wk and 4-5 wk of age. PMID: 21451062
    7. Kv4.3 is the major molecular component in GnRH neurons, and the expression of Kv4.3 changes significantly during the rat estrous cycle PMID: 20861393
    8. Downregulated Kv4.3 expression in the RVLM as a potential mechanism for sympathoexcitation in rats with chronic heart failure. PMID: 20044444
    9. Kv4.3 in migrating Purkinje cells with mediolateral compartmentalization. Purkinje cells no longer expressed Kv4.3 after completing migration. Kv4.3 may play important role in development of cerebellum and in mature cerebellum. PMID: 12911756
    10. Data suggest that the angiotensin receptor type 1 provides its internalization molecular scaffold to Kv4.3 and in this way regulates the cell surface representation of the ion channel. PMID: 15342638
    11. data suggest that Kv4.2 subunits could be involved in pain modulation. PMID: 16176357
    12. X-ray crystallographic and small-angle X-ray scattering data that show that the KChIP1-Kv4.3 N-terminal cytoplasmic domain complex is a cross-shaped octamer bearing two principal interaction sites. PMID: 17057713
    13. Novel function of Kv4.3-mediated A-type K+ currents in generation of intrinsic membrane potential oscillations in specific subpopulations of interneurons that may participate in hippocampal theta-related rhythmic activity. PMID: 17314290
    14. In a neuropathic pain model, the protein level of Kv4.3 is greatly reduced in dorsal root ganglion neurons. PMID: 17855600
    15. Kv4.3 and KChIP1 component subunits of A-type channels are co-localized in the soma and dendrites of a large number of GABAergic hippocampal interneurons PMID: 18495361
    16. Data suggest that the expression of Kv4.3 channels in the failing heart is redox-regulated by the thioredoxin system. PMID: 18515646
    17. Ang II acts via AT(1) receptors, NADPH oxidase and p38 MAP kinase to upregulate AUF1, which in turn binds to an ARE in the Kv4.3 3'UTR to destabilize the channel mRNA PMID: 18789946
    18. TRalpha1 and TRbeta1 exhibit distinct effects on KCND3 transactivation in cardiomyocytes, with TRalpha1 enhancing and TRbeta1 suppressing KCND3 transcription. PMID: 19171649

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection, dendrite.
  • 蛋白家族：
    Potassium channel family, D (Shal) (TC 1.A.1.2) subfamily, Kv4.3/KCND3 sub-subfamily
  • 组织特异性：
    Highly expressed in brain, in particular in the retrosplenial cortex, medial habenula, anterior thalamus, hippocampus, cerebellum and lateral geniculate and superior colliculus. Highly expressed in heart atrium (at protein level) and throughout the ventri
  • 数据库链接：

    KEGG: rno:65195

    STRING: 10116.ENSRNOP00000019997

    UniGene: Rn.10540