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  4. Recombinant Xenopus laevis Ephrin-B1 (efnb1)

Recombinant Xenopus laevis Ephrin-B1 (efnb1)

  • 中文名称：
    有爪蟾蜍efnb1重组蛋白
  • 货号：
    CSB-CF007465XBE
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    efnb1
  • Uniprot No.：
  • 别名：
    efnb1; eplg2; lerk2; Ephrin-B1; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; LERK-2; XlERK
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    21-329
  • 氨基酸序列
    LGKNLEPVTWNSQNPRFISGKGLVLYPEIGDRLDIICPKGDSSQPYEYYKLYMVRRDQLEACSTVIDPNVLVTCNQPGKEYRFTIKFQEFSPNYMGLEFRRNQDYYITSTSNSTLQGLENREGGVCQTRSMKIIMKVGQDPNAVPPEQLTTTRPSKEADNTGKIATFGPWNGPVENPGKSDTNLSDKPTAGGGVDGFFNSKIAVFAAIGAGCVIFILIIIFLVVLLIKIRKRHRKHTQQRAAALSLSTLASPKCSGNAGSEPSDIIIPLRTTENNYCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May have a role in the developing mesenchymal and nervous tissue.
  • 基因功能参考文献：
    1. interactions between Smurfs and ephrinB1 regulates the maintenance of tissue boundaries through the control of ephrinB protein levels PMID: 23475958
    2. Results identify the transcriptional co-repressor xTLE1/Groucho as an EphrinB1 interacting protein. PMID: 21429299
    3. Ephrin-B1 and Wnt3A signaling contribute to region-specific neuronal plasticity in the developing optic tectum. PMID: 20346764
    4. Tyrosine-298 in ephrin B1 is required for binding Grb4. PMID: 14535844
    5. EphrinB1 reverse signaling is required to promote cellular movements into the eye field, and can rescue the FGF receptor-induced repression of retinal fate. respectively. PMID: 14723847
    6. Gain- and loss-of-function experiments suggest that Xdsh associates with ephrinB1 and mediates ephrinB1 signalling through downstream members of the PCP pathway during eye field formation. PMID: 16362052
    7. recruitment of STAT3 to ephrinB1, and its resulting Jak2-dependent activation and transcription of reporter targets, reveals a signaling pathway from ephrinB1 to the nucle PMID: 17954917
    8. ephrinB1 associates with the Par polarity complex protein Par-6 and can compete with the small GTPase Cdc42 for association with Par-6. PMID: 18604196
    9. Data demonstrate that phosphorylation of tyrosines 324 and 325 of ephrin B1 disrupts the ephrinB1/Dishevelled interaction, thus modulating retinal progenitor movement that is dependent on the planar cell polarity pathway. PMID: 19005214

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Ephrin family
  • 组织特异性：
    Expressed at low levels in most tissues with highest levels in the kidney, oocytes, ovary and testis.
  • 数据库链接：

    KEGG: xla:394292

    UniGene: Xl.302